69: PARP-Inhibitors: Entering a New Era of Personalized Treatment for Advanced Prostate Cancer - Emmanuel Antonarakis, MD
The Prostate Health PodcastShow Notes
There is a continuous explosion of new and innovative therapies for men with advanced prostate cancer. Recently, two different PARP-Inhibitors were approved by the FDA for use. Those drugs were the first in their class to have been approved as personalized therapy for certain individuals with advanced prostate cancer. Today, we have Dr. Emmanuel Antonarakis, a world-class expert in the area of targeted therapy for prostate cancer, joining us to talk about the two new medications and explain who might be eligible for that kind of therapy. Be sure to stay tuned for more! Dr. Antonarakis is a Professor of Oncology and Urology at the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, as well as being Director of Prostate Cancer Medical Oncology Research and Co-Director of the Prostate Cancer Multidisciplinary Clinic, also at the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center. Since 2010, he has been on the Johns Hopkins faculty as an attending physician and translational researcher in the oncology department. Dr. Antonarakis' clinical interests include the management of prostate cancer. His research focus has included the development of novel androgen-directed therapies, genetically-targeted therapies, immunotherapies for men with recurrent or advanced prostate cancer, and using germline and cancer genomics to inform precision on oncology approaches. He is the author of over 290 peer-reviewed research articles and several book chapters. Disclaimer: The Prostate Health Podcast is for informational purposes only. Nothing in this podcast should be construed as medical advice. By listening to the podcast, no physician-patient relationship has been formed. For more information and counseling, you must contact your personal physician or urologist with questions about your unique situation. Show highlights: Dr. Antonarakis explains what led him down his chosen path. Dr. Antonarakis explains what a PARP-inhibitor is. Dr. Antonarakis talks about the PARP-inhibitors that are currently available for individuals with prostate cancer. These targeted therapies are not the same as chemotherapy. Dr. Antonarakis explains which men with prostate cancer could be candidates for a PARP-inhibitor. The type of genetic testing needed to determine who could be eligible for treatment with a PARP-inhibitor. Dr. Antonarakis talks about the points along the cancer journey when he would recommend genetic testing. The benefits, risks, and side effects of PARP-inhibitors.
Links: Follow Dr. Pohlman on Twitter and Instagram - @gpohlmanmd Get your free What To Expect Guide (or find the link here, on our podcast website) Join our Facebook group Follow Dr. Pohlman on Twitter and Instagram Go to the Prostate Health Academy to sign up for the wait-list for our bonus video content. You can access Dr. Pohlman's free mini webinar, where he discusses his top three tips to promote men's prostate health, longevity, and quality of life here.
More from The Prostate Health Podcast
For decades, prostate cancer treatment required critical decision-making based on an imperfect picture of the exact location and extent of the cancer. Artificial intelligence, however, can provide a much clearer, three-dimensional picture of each patient's cancer, helping us match the treatment to the individual. We're delighted to welcome board-certified urologist Dr. Pankaj Jain of Arizona Urology as today's guest. Dr. Jain completed his urology residency at Northwestern University. He is recognized as a leader in minimally invasive surgery and for adopting innovative technologies at the forefront of urologic care. Dr. Jain joins me today to explore how artificial intelligence is changing the way we understand and treat prostate cancer. I'm especially excited to discuss Unfold AI, a revolutionary new tool for planning and guiding prostate cancer treatment. Stay tuned to learn how AI is changing how we understand, plan for, and treat prostate cancer. We're excited to partner with Avenda Health to bring you this episode! Disclaimer: The Prostate Health Podcast is for informational purposes only. Nothing in this podcast should be construed as medical advice. By listening to the podcast, no physician-patient relationship has been formed. For more information and counseling, you must contact your personal physician or urologist with questions about your unique situation. Show Highlights: Dr. Jain explains what Unfold AI is and how it can help with prostate cancer treatment planning
We're grateful to partner with Procept BioRobotics to bring you this episode. Today, we're excited to welcome two special guests to the Prostate Health Podcast. Dr. Gerald Park, a board-certified urologist from Kansas City Urology Care, is a recognized innovator in BPH management and a pioneer in bringing advanced treatment technologies to patients throughout the region. J.D. is a 54-year-old gentleman who has struggled with BPH for many years. Like many men, his symptoms gradually worsened over the years, eventually impacting his bladder and kidney health. J.D.'s longstanding BPH journey brings today's conversation to life. With Dr. Park's guidance, he gained the clarity and confidence he needed to make an informed treatment decision and achieve meaningful relief from his symptoms. Stay tuned as we explore how modern patient-centered BPH consults can help patients better understand their condition, their treatment options, and the outcomes that matter most to them. Disclaimer: The Prostate Health Podcast is for informational purposes only. Nothing in this podcast should be construed as medical advice. By listening to the podcast, no physician-patient relationship has been formed. For more information and counseling, you must contact your personal physician or urologist with questions about your unique situation. Show Highlights: Dr. Park debunks the misconceptions most patients with bothersome urinary symptoms have about an enlarged prostate or BPH.
Artificial intelligence is transforming nearly every aspect of healthcare, but what does that actually mean for men with prostate cancer? Today, we are delighted to welcome Dr. Jason Hafron to discuss the Artera AI Prostate Test and explain how it helps clinicians and patients determine the optimal personalized prostate cancer treatment plan. Dr. Hafron is a board-certified urologist, the Chief Medical Officer and Medical Director of Clinical Research at the Michigan Institute of Urology, and a professor of urology at the William Beaumont School of Medicine at Oakland University in Royal Oak. He is experienced in all areas of urology, has published numerous peer-reviewed journal articles, and has presented his research at national and international scientific meetings. Stay tuned as we take a closer look at the Artera AI Prostate Test and explore how it is helping physicians better predict risk, personalize treatment plans, and give patients greater confidence as they make some of the most important decisions of their lives. We are excited to partner with Artera for this episode of the Prostate Health Podcast. Disclaimer: The Prostate Health Podcast is for informational purposes only. Nothing in this podcast should be construed as medical advice. By listening to the podcast, no physician-patient relationship has been formed. For more information and counseling, you must contact your personal physician or urologist with questions about your unique situation. Show Highlights: Why prostate cancer treatment decisions need to be personalized
We are excited to partner with Richard Wolf Medical Instruments, a company at the forefront of urologic innovation and advanced surgical technology, for this episode of the Prostate Health Podcast. For decades, men with enlarged prostates have had to choose between living with disruptive urinary symptoms and undergoing invasive surgery. Now, holmium laser enucleation of the prostate, or HoLEP, is changing that by offering a minimally invasive treatment with proven long-term results, while new surgical innovations are taking the procedure to the next level. Today's guest is Dr. Austin Slade, a nationally and internationally recognized urologic surgeon and one of the most experienced HoLEP specialists in the United States. Known for his surgical precision, exceptional patient outcomes, and commitment to advancing minimally invasive prostate care, Dr. Slade is sought out by patients and referring physicians from across the United States and around the world for the treatment of enlarged prostate symptoms. Join us as Dr. Slade offers his insights on why the HoLEP procedure has become a leading long-term treatment for BPH and how recent advances in surgical instrumentation are enabling surgeons to deliver even better outcomes for their patients. Disclaimer: The Prostate Health Podcast is for informational purposes only. Nothing in this podcast should be construed as medical advice. By listening to the podcast, no physician-patient relationship has been formed. For more information and counseling, you must contact your personal physician or urologist with questions about your unique situation. Show Highlights: What is BPH, and when should you seek evaluation?
We are thrilled to partner with BioProtect for this episode of the Prostate Health Podcast. Radiation therapy is a highly effective treatment for prostate cancer. Navigating potential side effects, particularly radiation effects on the rectum, is a key challenge when making a decision. Fortunately, a new technology helps reduce the short- and long-term risks associated with treatment. Today, for the first time on the podcast, we're featuring both a urologist and a radiation oncologist to give our listeners a true multidisciplinary perspective on how a biodegradable balloon spacer provides precise, predictable spacing for radiation therapy in prostate cancer. We are delighted to have board-certified urologist Dr. Jeffrey Wolters, MD, and board-certified radiation oncologist Dr. Coyt Rountree, MD, both from Florida Cancer Specialists, joining us today. Dr. Wolters and Dr. Rountree are leading experts in the management of prostate cancer with significant experience using the BioProtect balloon spacer. Stay tuned for more! Disclaimer: The Prostate Health Podcast is for informational purposes only. Nothing in this podcast should be construed as medical advice. By listening to the podcast, no physician-patient relationship has been formed. For more information and counseling, you must contact your personal physician or urologist with questions about your unique situation. Show Highlights: What patients need to know about radiation before starting treatment