The Good GP

The Basics of the Immune System: How Your Body Defends and Balances Itself

The Good GP

Show Notes

In this episode of This Could Save Your Life podcast, Dr Catherine Bourke is joined by Dr Jack Bourke, clinical immunologist and immunopathologist, to discuss the fundamentals of the immune system. Dr Jack explains the core functions of the immune system, including defending against pathogens such as viruses, bacteria, parasites, and fungi, as well as identifying and removing abnormal or cancerous cells. The distinction between the innate (rapid, broad-acting, present from birth) and adaptive (specific, develops over time, retains memory) components of immunity is outlined. Describing the diffuse nature of the immune system across the body, incorporating white blood cells, bone marrow, thymus, lymph nodes, spleen, tonsils, adenoids, skin, and mucosal surfaces. The implications of removing structures like tonsils, adenoids, and especially the spleen are discussed, noting that only loss of the spleen is associated with significant immune deficiency and additional infection risk. Dr Jack addresses the misconception that the immune system is only active during illness. Reviewing the role of lifestyle factors on immune health, alongside the lack of evidence for most over-the-counter “immune-boosting” products outside correction of proven deficiencies. Key evidence-based interventions to support immune health include vaccination, healthy diet, physical activity, adequate sleep, and chronic disease management. This Could Save Your Life Podcast is under The Good GP podcast, a proud member of the Talking HealthTech Podcast Network - the premier audio destination for cutting-edge insights and thought leadership in healthcare delivery, innovation, digital health, healthcare ICT, and commercialisation. Learn more at www.talkinghealthtech.com/podcast/network If you have any questions or would like to contact The Good GP, send an email to [email protected]. Visit www.thegoodgp.com.au for previous episodes and more information. You can also find us on our Instagram page: @thegoodgppodcast. Follow us for more updates! Mentioned in this episode: Build the Career and Lifestyle You’ve Been Looking For, in the Vines. Tired of traffic, long commutes, and feeling stuck in the grind? The Mudgee Region is calling.

The Doctors 4 Mudgee Region initiative is working to attract and support GPs and registrars looking to build rewarding, sustainable careers in one of NSW’s most sought after regional destinations, just 3 hours from Sydney. With financial incentives of up to $45,000 for fellowed doctors and lifestyle concierge support for all relocating practitioners, there’s never been a better time to make the move.

Learn more at www.doctors4mudgee.com.au Doctors 4 Mudgee Region

More from The Good GP

Oct 19, 2026

In this episode of The Good GP, Dr Krystyna de Lange speaks with Dr Steph Daly, GP with a special interest in aged care and dementia, about the introduction of plasma biomarkers, specifically the p-Tau 217 blood test for Alzheimer’s disease. They explore what the p-Tau 217 test measures, its reliability, and its role in primary care.

Oct 12, 2026

In this episode of The Good GP, host Dr Krystyna De Lange speaks with Dr David Leitinger, a GP with a special interest in addiction medicine, about the practical use of naltrexone for managing alcohol use disorder (AUD).

Oct 5, 2026

In this episode of The Good GP, Dr Julia Rawlinson speaks with Dr Florence Martin, an epidemiologist specialising in pregnancy pharmacoepidemiology. Dr Martin discusses her recent study examining the relationship between first trimester antidepressant use and miscarriage risk, using UK primary care data from the CPRD GOLD database.

Sep 28, 2026

In this episode of the Good GP, Dr Julia Rawlinson speaks with Dr Julia Feutrill, consultant psychiatrist at King Edward Memorial Hospital and co-director of the Elizabeth Clinic. They discuss the complexities of antidepressant use during pregnancy, providing GPs with practical advice for navigating these conversations.

Sep 21, 2026

In this episode of the Good GP, Dr Julia Rawlinson speaks with Dr Paul Effler, Senior Medical Advisor at the WA Department of Health and expert in communicable diseases, about H5N1 avian influenza and pertussis.

See all episodes →