Freely Filtered 058: HCTZ v Chlorthalidone, The Diuretic Comparison Project
Freely Filtered, a NephJC PodcastShow Notes
The Filtrate: Joel Topf Swapnil Hiremath Josh Waitzman Jordy Cohen
With Special Guest: Areef ishani lead author and Chief of Medicine VA Minneapolis
Editor: Nayan Arora
Show Notes: MRFIT switches diuretics and finds better outcomes. Swapnil shows how many studies he is familiar with by spewing out a string of them. Chlorthalidone wins: ALLHAT, MRFIT, SPRINT, HYVET, CLICK (not mentioned by Swap but by Jordy later) HCTZ loses: HOPE3, ACCOMPLISH Diuretic half-lifes NEJM review Edarbyclor: Azilsartan and Chlorthalidone $240/month as per GoodRx Nice mention of late study originator Frank Lederle. Please see his article in Annals about his diagnosis of pancreatic cancer. Moving. Network analysis of HCTZ vs chlorthalidone Antihypertensive efficacy of hydrochlorothiazide vs chlorthalidone combined with azilsartan medoxomil by George Bakris Synopsis of the 2020 U.S. Department of Veterans Affairs/U.S. Department of Defense Clinical Practice Guideline: The Diagnosis and Management of Hypertension in the Primary Care Setting (Annals of Internal Medicine) Testing for Primary Aldosteronism and Mineralocorticoid Receptor Antagonist Use Among U.S. Veterans: A Retrospective Cohort Study by Jordy Cohen Study showing better risk reward ratio of low dose than high dose thiazide diuretics. Treatment of hypertension in the elderly: I. Blood pressure and clinical changes. Results of a Department of Veterans Affairs Cooperative Study. Tubular Secretions Swapnil Louise Penny author of book upon which the Amazon Prime series, Three Pines is based on. Jordy Last of Us series on HBO Josh Channel Your Enthusiasm A Very Special Episode: Meet the Glaucomfleckens Areef The Body: A Guide for Occupants Joel NephMadness (this did not age well)
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