Show Notes
GiveWell tends to be known for its work in areas like malaria prevention, water treatment, and nutrition. But as our research team has grown, so has our ability to search for cost-effective programs across a much wider range of issues.
Serious health problems, such as lack of medical oxygen and stockouts of essential medicines at health facilities, affect millions of people in low-income countries. There may be highly cost-effective solutions to these problems that haven’t been thoroughly evaluated or adequately funded. One of the ways GiveWell is searching for these solutions is through the new areas research subteam, which investigates programs in cause areas GiveWell hasn’t historically focused on. In this episode, GiveWell co-founder and CEO Elie Hassenfeld speaks with Senior Program Officer Dan Brown about GiveWell’s new areas research subteam and three grants that illustrate the team’s work.
Elie and Dan discuss: Evaluating whether electronic tracking can improve access to health supplies: In many low- and middle-income countries, health facilities track their medicine supplies on paper, with stock counted roughly once a month for only a subset of products. As a result, staff may be less able to accurately predict inventory levels. This can lead to stockouts, making it more difficult for people to access the treatment they need, or to surplus commodities, which could result in expired medicines. GiveWell is funding the Clinton Health Access Initiative (CHAI) and mSupply Foundation to implement an electronic supply chain management system in health facilities in Laos and conduct a randomized controlled trial measuring whether the system reduces stockouts and improves patients’ access to the treatments they need. If we learn that more people are able to access treatment as a result, funding the rollout of this type of software in countries facing higher burdens of disease could be a cost-effective strategy for reducing mortality. Supporting a new approach to medical oxygen production: Medical oxygen is essential for treating severe pneumonia, malaria, and many other health conditions—yet access in low-income countries remains limited. GiveWell is funding PATH to assess the market viability of a recently developed oxygen-producing device that appears to require far less maintenance than existing technology. This is an early-stage investment focused on understanding manufacturing costs and potential demand. PATH’s work will run concurrently with research funded by other organizations assessing whether the device works effectively in real-world conditions in low-income countries. We’re also investigating other opportunities to improve the ability to diagnose low oxygen and increase access to a reliable oxygen supply in health facilities. Investigating a caregiver training program for newborn health: Noora Health’s Care Companion Program trains family members in practices that support maternal and newborn health, including skin-to-skin contact, breastfeeding techniques, and how to recognize illness warning signs. The existing evidence base for these practices is limited to one study without a control group (making it difficult to assess if the practices actually caused the results), so GiveWell is funding two studies in India: a pilot study assessing intermediate health outcomes like sepsis and umbilical cord infections that are linked to newborn mortality, and a larger randomized controlled trial measuring the program’s effect on neonatal mortality. We expect that these studies will provide additional evidence needed to assess whether to fund the program at scale, potentially reducing childhood deaths.
These grants reflect just a few of the ways GiveWell’s research is expanding to identify more high-impact opportunities to help people. GiveWell is hiring to expand our research team further—including positions on the new areas subteam—so we can cover more ground and ultimately direct more donor funding faster to programs
More from GiveWell Conversations
In an effort to direct substantially more funding to the most cost-effective opportunities we can find to help people, GiveWell’s research is expanding in two directions at once: going broader, to cover more areas of global health and development, and going deeper, to improve the inputs that inform our decision-making.
GiveWell works to continually improve our research so we can make better grant decisions and direct donations where we believe they can do the most good. GiveWell’s Cross-Cutting research subteam is an important part of that effort—it investigates the impact of the programs we fund, works to resolve our largest uncertainties, and aims to improve our research. As GiveWell’s grantmaking grows, the Cross-Cutting subteam is strengthening our data collection and analysis to support that growth. In this episode, GiveWell co-founder and CEO Elie Hassenfeld speaks with Program Director Alex Cohen, who leads the Cross-Cutting subteam, about how better data can improve our decision-making, our work to gather stronger evidence, and the ways we’ve tested AI as a tool to increase our research capacity and quality.
GiveWell, with co-funding from Coefficient Giving, recently made our largest grant to date: $276 million to the Against Malaria Foundation (AMF) to support the procurement and distribution of 92 million nets in the Democratic Republic of the Congo (DRC) from 2027 through 2029. We estimate that the nets, 46 million of which we think would not otherwise be distributed, will avert roughly 67,000 deaths. We have supported AMF’s work for more than 15 years, and the insecticide-treated nets it procures and distributes remain one of the most cost-effective ways we've found to save lives.
When GiveWell investigates a new cause area, we’re often focused on two priorities: directing funding where we think it can help people most and generating evidence to inform larger investments later. Family planning is a clear example. Recent foreign aid cuts—including reductions from the US, UK, and Dutch governments—deepened an already substantial need and opened up new cost-effective funding opportunities.
Diarrhea is one of the leading causes of death for children under five, killing more than 400,000 children every year. GiveWell has funded several programs to prevent and treat diarrhea, and we recently expanded our work by making a grant to support the implementation and evaluation of WASHmobile in the Democratic Republic of the Congo (DRC) and South Sudan. The program, which was developed by Johns Hopkins University, delivers water treatment supplies and hygiene messaging to households at the highest risk of diarrheal disease. It has shown promising results in randomized controlled trials (RCTs) but hasn’t yet been implemented at scale in the challenging settings where the need is greatest.