The Energy Balance Podcast

EB. 137: What REALLY Causes Glycation (Is Sugar Really the Problem?)

The Energy Balance Podcast

Show Notes

In this episode we discuss:

Why glucose and fructose are not the primary drivers of AGE formation

Whether blood sugar spikes cause glycation

How fats and ketones can cause glycation

What’s really responsible for glycation in type 2 diabetes

Whether fructose causes more glycation than glucose

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/ Check out the Energy Balance Solution Program here: https://www.jayfeldmanwellness.com/energy-balance-solution/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/eb-137-what-really-causes-glycation-is-sugar-really-the-problem/

Timestamps: 0:00 – intro 0:46 – common beliefs about carbohydrates and glycation 2:35 – what are glycation and advanced glycation end products? 6:57 – the process of glycation from glucose 9:30 – is sugar the only source of AGEs? 15:00 – primary drivers of glycation: dicarbonyls 19:30 – how fatty acids, amino acids, and ketones cause AGE formation 21:23 – how increased gluconeogenesis on low-carb diets increases AGE formation 22:53 – glucose metabolism produces very few glycation products in the context of a healthy metabolism 25:33 – omega-6s form AGEs more than 10x faster than glucose 28:24 – the role of ALEs (advanced lipoxidation end products) in glycation and chronic disease 30:36 – whether blood sugar spikes cause glycation 38:52 – whether fructose causes more glycation (or fructation) than glucose 47:05 – can glycation from fructose (fructation) be measured, and does this matter? 52:06 – problems with research looking at fructose’s AGE formation in animal models

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