Show Notes
Ryan Smith is the founder of TruDiagnostic and a leading voice in biological ageing, hormone science, and health optimisation. In this episode, we get into the real drivers of long-term vitality, why most people are tracking the wrong markers, how to train and supplement based on your biological age, and what bloodwork actually matters.
We also touch on the emerging field of methylation clocks and how to think about reversing your true age, not just your appearance. Whether you’re already deep into your health stack or just starting to explore it, this is a sharp, grounded conversation that cuts through the noise.
00:00 Introduction 02:10 Epigenetics, biological age, and the future of health 02:38 Leaving medical school to build a peptide pharmacy 04:34 Discovering biological clocks as better health markers 06:13 How epigenetic testing works with one drop of blood 09:45 Current limits of personalised lifestyle recommendations 11:25 Predicting biomarkers and disease risk from methylation 15:08 Best diet for longevity across all tested options 17:49 Measuring biological age of 11 different organ systems 21:33 Tadalafil's surprising longevity benefits and gender split 24:43 Social bonds, stress, and psychological health matter 26:01 Supplements ranked for biological age improvement 29:49 Stronger interventions like SGLT2 inhibitors and fast mimetics 33:16 Data on fasting duration and calorie restriction 37:00 Best longevity peptides and promising new compounds 38:59 Therapeutic plasma exchange and young blood potential 42:32 Sleep, sex, and movement as core health levers 44:51 Psychedelics and ketamine showing anti-aging promise 48:23 When lifestyle changes backfire and how to adjust 50:19 How to start testing and find a reliable provider
DISCLAIMER Nothing shared on this podcast is a substitute for professional medical guidance. Please consult a healthcare professional before making any health or lifestyle changes.
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