Show Notes
Show Notes
š¬ Artificial intelligence and big data are flooding discovery pipelines with high-potential drug candidates, but this rapid innovation has triggered significant challenges. Simply put, our capability to design miracle molecules is vastly outstripping our technology to mass-manufacture them safely for the global public. Moving drug making from the scale of lab flasks to commercial bioreactors introduces non-linear biological and engineering shifts that can undermine tasks like purification.
ā”In this New Scientist CoLab podcast, experts from global life sciences leader Cytiva explain the hidden, high-stakes science of purification that is required to close the gap between drug discovery and the pharmacy shelf.
Our guests are:
Henrik Ihre, Distinguished Fellow, Cytiva
Paul Belcher, Business Leader, Cytiva
š§ Stay tuned to learn about:
ā” The process of taking a drug from theoretical to the shop shelf
ā” How the drug purification works
ā” The human cost when purification goes wrong
ā” The challenges of keeping pace in manufacturing as AI supercharges drug discovery
Chapters:
(00:00) Intro - How drugs go from discovery to reality
(03:49) The purification process
(10:05) Why small scale success doesn't mean industrial scale success
(13:00) The challenge of the expanding drug pipeline
(21:39) Understanding the molecules that are being purified
(23:20) What is a chromatography resin?
(25:24) Why purification gets more difficult later in the process
(27:15) The human impact when purification goes wrong
(32:59) The future of AI drug discovery
(37:52) Is AI helping with purification?
(40:32) How it feels to be advancing drug discovery
About the sponsor:
Cytiva: ā https://www.cytivalifesciences.com/ ā
About the podcast:
New Scientist CoLab explores the boundaries of innovation and the intersection of business, science and technology. Hosted by Justin Mullins.
Don't miss an episode - subscribe now:
ā https://www.youtube.com/@NewScientistCoLabā
Connect with New Scientist:
Website: ā https://www.newscientist.com/ā
Instagram: ā https://www.instagram.com/newscientist/ā
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