The Thyroid (and Hormone) Fixer Podcast: Thyropause, Menopause, Metabolism and How to Fix It

657. Why Knowing Your DNA is VITAL for Personalized Medicine and Disease Prevention

The Thyroid (and Hormone) Fixer Podcast: Thyropause, Menopause, Metabolism and How to Fix It

Show Notes

In this episode, I’m joined by Dr. Tracey Steady Hardcastle, Clinical Director of The DNA Company, to talk about what our genetics can actually tell us about our health. We use my own genetic report as a real-life example, looking at why people can respond so differently to thyroid medication, hormone therapy, nutrition, and lifestyle changes, and why a more personalized approach matters.

Dr. Tracey walks through some fascinating findings from my report, including estrogen metabolism, thyroid hormone conversion, detoxification, methylation, stress, and genetic risk. We also talk about what genetic testing can and can't tell us, and why having a genetic predisposition doesn't mean a particular health outcome is inevitable.

What you’ll learn:

Why the same treatment can affect two people very differently

What your genetic “blueprint” can reveal about your health

What my DNA report showed about estrogen and thyroid hormones

The role genetics can play in detoxification and methylation

How stress can interact with your genetic makeup

What ApoE and other genetic risk markers really mean

Why your genes aren't necessarily your destiny

If you’ve ever wondered why the same treatment doesn’t work for everyone, struggled to find the right approach to your thyroid or hormones, or simply wanted to understand what your own genetics might be telling you, tune in to this conversation with Dr. Tracey Steady Hardcastle.

Resources from Dr. Tracey:

The DNA Company: https://thednacompany.com/

Book a Free Call and Order a DNA Kit: https://dramie.com/

Grab your Thyroid Fixer here: https://betterlifedoctor.com/

New here? Use code LISTEN20 for 20% off your first order

Returning customers can use code LISTEN10 for 10% off

SHOP DR. AMIE’S FIXXR® SUPPLEMENTS:

betterlifedoctor.com

LET'S GET YOUR LIFE BACK...Connect with Dr. Amie Hornaman

Book a free thyroid and hormone solution call:

https://dramiehornaman.com/pages/book-a-call

CHECK OUT MY FREEBIES... JUST CLICK BELOW

Thyroid Optimization Guide: https://health.dramie.com/thyropause

7 Day Thyroid Healing Kickstarter: https://fixyourthyroid.com/7daykickstarter

Thyroid on Trial: https://health.dramie.com/thyroid-on-trial-optin

RATE, REVIEW AND FOLLOW ON APPLE PODCASTS

Show your love for Dr. Amie and The Thyroid Fixer Podcast! If you’re enjoying our journey together, I’d be thrilled if you could take a moment to rate and review the show on Apple Podcasts. Your support helps me reach and help more people just like you, guiding them towards their optimal selves! Just click⁠HERE⁠ (https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263), scroll all the way down, give us those 5 stars, and share what you enjoy about my episodes in a review.

Haven’t subscribed yet? Make sure to follow The Thyroid Fixer Podcast to catch all the new episodes that come out every week. Follow⁠HERE⁠ (https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263) and never miss out on a moment of the journey!

CONNECT WITH ME ON SOCIAL MEDIA:

Join my exclusive Facebook Group and get questions answered LIVE weekly, Just Fix Your Thyroid, for a Community of HOPE and SUPPORT in your thyroid journey.

⁠https://www.facebook.com/groups/dramie/⁠ (https://www.facebook.com/groups/dramie/)

Like me on Facebook:⁠Amie Hornaman Nutrition and Functional Medicine⁠ (https://www.facebook.com/amiehornamannutrition/)

Subscribe on YouTube:⁠Dr. Amie Hornaman⁠ (https://www.youtube.com/c/dramiehornaman)

Follow me on Instagram:⁠@dramiehornaman⁠ (https://www.instagram.com/dramiehornaman/)

More from The Thyroid (and Hormone) Fixer Podcast: Thyropause, Menopause, Metabolism and How to Fix It

Oct 20, 2026

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Oct 16, 2026

What if the reason you still feel exhausted, foggy, and stuck isn't your thyroid or your hormones on their own, but the fact that no one is treating them together? In this episode, I'm breaking down why your thyroid and your sex hormones (estrogen, progesterone, and testosterone) play in the same sandbox, and why splitting them between two providers who never talk to each other can leave you coordinating your own care. Consider this my public service announcement on hormones-in-a-box clinics, algorithm-based dosing, and what improperly managed hormones can mean for your health and longevity. We also get into why you can't supplement your way to optimal sex hormone levels, why "within normal limits" isn't the same as optimal, and how oral estrogen can raise binding proteins like SHBG (sex hormone binding globulin) and TBG (thyroid binding globulin), which may leave you feeling worse. I also share the exact questions to ask before you start hormone therapy, the red flags to watch for, and the training I look for in a hormone provider. What you'll learn: Why your thyroid and sex hormones need to be treated together, not by two separate providers Why supplements and over-the-counter creams can only take you so far in perimenopause and menopause What "within normal limits" misses, and why a total testosterone of 40 may still be below optimal for women How oral estrogen can raise SHBG and TBG and affect your thyroid and testosterone Why estrone matters and why it's worth testing alongside estradiol Which questions to ask a provider before you hand over your money What red flags to watch for in hormones-in-a-box and pop-up hormone clinics Why you may still benefit from progesterone even if you don't have a uterus Tune in to learn how to find a provider who knows which lever to pull when your body doesn't follow the textbook. Grab your Thyroid Fixer here: https://betterlifedoctor.com/ New here? Use code LISTEN20 for 20% off your first order Returning customers can use code LISTEN10 for 10% off SHOP DR. AMIE'S FIXXR® SUPPLEMENTS: betterlifedoctor.com LET'S GET YOUR LIFE BACK...Connect with Dr. Amie Hornaman Book a free thyroid and hormone solution call: https://dramiehornaman.com/pages/book-a-call CHECK OUT MY FREEBIES... JUST CLICK BELOW Thyroid Optimization Guide: https://health.dramie.com/thyropause 7 Day Thyroid Healing Kickstarter: https://fixyourthyroid.com/7daykickstarter Thyroid on Trial: https://health.dramie.com/thyroid-on-trial-optin RATE, REVIEW AND FOLLOW ON APPLE PODCASTS Show your love for Dr. Amie and The Thyroid Fixer Podcast! If you're enjoying our journey together, I'd be thrilled if you could take a moment to rate and review the show on Apple Podcasts. Your support helps me reach and help more people just like you, guiding them towards their optimal selves! Just click HERE (https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263), scroll all the way down, give us those 5 stars, and share what you enjoy about my episodes in a review. Haven't subscribed yet? Make sure to follow The Thyroid Fixer Podcast to catch all the new episodes that come out every week. Follow HERE (https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263) and never miss out on a moment of the journey! CONNECT WITH ME ON SOCIAL MEDIA: Join my exclusive Facebook Group and get questions answered LIVE weekly, Just Fix Your Thyroid, for a Community of HOPE and SUPPORT in your thyroid journey. https://www.facebook.com/groups/dramie/ Like me on Facebook: Amie Hornaman Nutrition and Functional Medicine (https://www.facebook.com/amiehornamannutrition/) Subscribe on YouTube: Dr. Amie Hornaman (https://www.youtube.com/c/dramiehornaman) Follow me on Instagram: @dramiehornaman (https://www.instagram.com/dramiehornaman/) Disclaimer: Information provided on The Thyroid Fixer® podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or

Oct 13, 2026

What if one of the most useful health trackers you could own wasn't on your wrist, but on your toilet? In this episode, I'm joined by Scott Hickle, engineer and founder of Throne, a camera that clips onto your toilet and tracks your gut health, hydration, and bathroom habits every time you go. We get into what your poop and pee can reveal about your health and what the Bristol Stool Scale (a 1-to-7 chart of stool form) actually tells you. We also cover why your memory of your own bathroom habits is far worse than you think. We also talk about how Throne's AI helps you connect gut changes to stress, travel, food, supplements, or new medications like GLP-1s. Scott walks through what can throw off the readings, from blue toilet cleaner to vitamin B and methylene blue. He explains why embarrassment can keep people from getting checked for things like colon cancer. He also shares a surprising link between under-hydration, vasopressin (the hormone that helps your body hold onto water), and your blood sugar response, which I connect back to thyroid function and weight. What you'll learn: What your stool form, color, and frequency can reveal about your gut health How Throne tracks hydration, bathroom habits, and urinary flow automatically Why your memory of your own bathroom habits is so unreliable How to run your own experiments with diet, supplements, probiotics, and GLP-1s What can throw off hydration readings, from vitamin B to methylene blue Why Scott believes embarrassment is a real risk factor for delayed diagnosis - How under-hydration may affect your blood sugar, thyroid, and weight What Scott says to look for in the toilet tomorrow, with or without a device If you've ever ignored what's happening in the toilet, this episode will show you why it's worth paying attention. Tune in to learn what your poop and pee may be telling you about your health, and why it's worth paying attention to what's happening in the toilet. ——— Thyroid Fixer listeners can save on Throne at https://thronescience.com/discount/DRAMIE or use code DRAMIE at checkout. Grab your Thyroid Fixer here: https://betterlifedoctor.com/ New here? Use code LISTEN20 for 20% off your first order Returning customers can use code LISTEN10 for 10% off SHOP DR. AMIE'S FIXXR® SUPPLEMENTS: betterlifedoctor.com LET'S GET YOUR LIFE BACK...Connect with Dr. Amie Hornaman Book a free thyroid and hormone solution call: https://dramiehornaman.com/pages/book-a-call CHECK OUT MY FREEBIES... JUST CLICK BELOW Thyroid Optimization Guide: https://health.dramie.com/thyropause 7 Day Thyroid Healing Kickstarter: https://fixyourthyroid.com/7daykickstarter Thyroid on Trial: https://health.dramie.com/thyroid-on-trial-optin RATE, REVIEW AND FOLLOW ON APPLE PODCASTS Show your love for Dr. Amie and The Thyroid Fixer Podcast! If you're enjoying our journey together, I'd be thrilled if you could take a moment to rate and review the show on Apple Podcasts. Your support helps me reach and help more people just like you, guiding them towards their optimal selves! Just click HERE (https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263), scroll all the way down, give us those 5 stars, and share what you enjoy about my episodes in a review. Haven't subscribed yet? Make sure to follow The Thyroid Fixer Podcast to catch all the new episodes that come out every week. Follow HERE (https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263) and never miss out on a moment of the journey! CONNECT WITH ME ON SOCIAL MEDIA: Join my exclusive Facebook Group and get questions answered LIVE weekly, Just Fix Your Thyroid, for a Community of HOPE and SUPPORT in your thyroid journey. https://www.facebook.com/groups/dramie/ Like me on Facebook: Amie Hornaman Nutrition and Functional Medicine (https://www.facebook.com/amiehornamannutrition/) Subscribe on YouTube: Dr. Amie Hornaman (https://www.youtube.com/c/dramiehornaman) Follow me on Instagram: @dramiehornaman (https:/

Oct 9, 2026

What if Alzheimer's doesn't begin when you start forgetting things, but decades earlier, with your blood sugar, your waistline, and your hormones? In this episode, I'm joined by Dr. David Perlmutter, Board-Certified Neurologist and author of Grain Brain and his new book, Brain Defenders, to unpack why your brain's future is something you can influence. We talk about microglia, the brain's own immune cells, how they shift from protecting your brain to damaging it, and why chasing beta amyloid may be missing the bigger picture. We also get into how thyroid hormone, especially T3, fuels the mitochondria that help keep those immune cells supportive. We look at why the drop in estrogen during perimenopause may help explain why two-thirds of Alzheimer's patients are women. Dr. Perlmutter shares where he stands on hormone replacement therapy and testosterone and what the research says so far about GLP-1 medications and brain health. He also names the labs he wants everyone in their 30s, 40s, and 50s to know, including fasting insulin, A1C, and homocysteine. What you'll learn: Why Alzheimer's may begin decades before memory loss shows up Why Dr. Perlmutter says carrying the APOE4 gene variant means predisposed, not predetermined What microglia are and how they shift from supportive to destructive How blood sugar, gut inflammation, and head trauma can all affect your brain's immune cells How thyroid hormone and your mitochondria work together to support brain energy Why falling estrogen during perimenopause may put women's brains at greater risk Where Dr. Perlmutter stands on hormone replacement therapy and testosterone What the research says so far about GLP-1 medications and the brain Tune in to learn how to start protecting your brain now, long before any symptoms show up. Resources from Dr. David Perlmutter: Brain Defenders (book): https://braindefenders.com Website: https://drperlmutter.com Podcast: The Empowering Neurologist Follow Dr. Perlmutter on social media: Instagram: @davidperlmutter Youtube: https://www.youtube.com/user/DavidPerlmutterMD X: @davidperlmutter Linkedin: linkedin.com/in/david-perlmutter-md Grab your Thyroid Fixer here: https://betterlifedoctor.com/ New here? Use code LISTEN20 for 20% off your first order Returning customers can use code LISTEN10 for 10% off SHOP DR. AMIE'S FIXXR® SUPPLEMENTS: betterlifedoctor.com LET'S GET YOUR LIFE BACK...Connect with Dr. Amie Hornaman Book a free thyroid and hormone solution call: https://dramiehornaman.com/pages/book-a-call CHECK OUT MY FREEBIES... JUST CLICK BELOW Thyroid Optimization Guide: https://health.dramie.com/thyropause 7 Day Thyroid Healing Kickstarter: https://fixyourthyroid.com/7daykickstarter Thyroid on Trial: https://health.dramie.com/thyroid-on-trial-optin RATE, REVIEW AND FOLLOW ON APPLE PODCASTS Show your love for Dr. Amie and The Thyroid Fixer Podcast! If you're enjoying our journey together, I'd be thrilled if you could take a moment to rate and review the show on Apple Podcasts. Your support helps me reach and help more people just like you, guiding them towards their optimal selves! Just click HERE: (https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263), scroll all the way down, give us those 5 stars, and share what you enjoy about my episodes in a review. Haven't subscribed yet? Make sure to follow The Thyroid Fixer Podcast to catch all the new episodes that come out every week. Follow HERE: (https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263) and never miss out on a moment of the journey! CONNECT WITH ME ON SOCIAL MEDIA: Join my exclusive Facebook Group and get questions answered LIVE weekly, Just Fix Your Thyroid, for a Community of HOPE and SUPPORT in your thyroid journey. https://www.facebook.com/groups/dramie/ Like me on Facebook: Amie Hornaman Nutrition and Functional Medicine (https://www.facebook.com/amiehornamannutrition/) Subscribe on YouTube: Dr. Amie Hornaman (https://www.youtube.com/c/dramieho

Oct 6, 2026

Gut health is about far more than bloating and constipation. In this episode, I’m joined by Laura Frontiero to unpack the overlooked ways gut dysfunction can show up, from fatigue and brain fog to skin issues, joint pain, sleep problems, and thyroid challenges. We also talk about why common gut protocols don’t always work and why the order in which you address gut health matters.

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