STUMP - Death and Taxes

Research Fraud Follow-Up: What Happened to Fraudsters and How to Make It Less Common

STUMP - Death and Taxes

Show Notes

Following up a prior episode on fraud in Alzheimer’s research, I look at what has happened to two of those researchers, talk about my own experience in preventing cheating in classes as well as what academic research was like as an RA (research assistant) in physics, and then look at what current research fraud prevention in the U.S. federal government looks like with some advice for future activities.

Episode Links Alzheimer’s Research Fraud Dan Elton post: 20 Oct 2024 Profiles: Berislav Zlokovic * Number of papers found with suspicious images - “dozens” * Influential papers with fraud - Nature Medicine (2004), Stroke (2013), The Journal of Neuroscience (2013), Frontiers in Neuroscience (2022) * Taxpayer money lost as a result - at least 30 million * Pharma company impacts - ZZ Biotech received 30 million from the NIH to explore drug candidate 3K3A-APC for stroke recovery based on Zlokovic’s work. The drug didn’t work and there were six deaths in the active group compared to one in the placebo group. Suspect papers have been cited in 49 patents by 30 companies, universities, and foundations. Notes: As explained in Science’s expose, Zlokovic is the top-ranked researcher in the world when it comes to Alzheimer’s and the blood-brain barrier, both in terms of number of papers (25) and number of citations (14,341). Suspect papers affect both the Alzheimer’s and stroke research fields. Two former lab members say that Zlokovic instructed them to make sure their lab notebooks were “clean”, meaning making sure they did not have data and results that challenged their paper’s conclusions. …. Hoau-Yan Wang * Number of papers found with suspicious images - 20 * Influential papers with fraud - The Journal of Neuroscience (2012) * Taxpayer money lost as a result - at least $16 million, probably a lot more. * Pharma company impacts - Cassava Biosciences based their clinical trials of Simufilam off of Wang’s work. Wang served as an advisor to the company. Notes: The fraudster remains a professor at CUNY, despite CUNY doing a 50 page investigation that found “highly suggestive” evidence that he is culpable for 14/31 allegations. A June 2024 indictment by the Department of Justice states that he also committed fraud on grant applications between 2017 to 2021. The fraudulent applications led to $16 million in grant funding to Wang from the NIH. Science: Top Alzheimer’s researcher goes ‘on leave’ amid misconduct concerns, 8 Nov 2024 Berislav Zlokovic, a prominent Alzheimer’s disease and stroke researcher who has long headed a major neuroscience institute at the University of Southern California (USC), is now on an indefinite leave of absence, according to a school official. USC declined to clarify a reason for the leave, but Zlokovic has faced scrutiny since a 2023 Science investigation described evidence that he had engaged in scientific misconduct for decades. Science has also learned that a planned $30 million clinical trial of a stroke drug candidate Zlokovic helped develop has been formally called off by its company sponsor, and the National Institutes of Health (NIH) has required that USC return nearly $2 million in funding for the trial. USC Keck School of Medicine Dean Carolyn Meltzer announced Zlokovic’s leave in a 22 October email to USC faculty, obtained by Science. She named neuroscientist Steve Kay as acting director of the university’s Zilkha Neurogenetic Institute and its Department of Physiology & Neuroscience, both of which Zlokovic previously headed. According to a USC professor who requested anonymity, Kay has taken over Zlokovic’s laboratory. Zlokovic also stepped down as co-director of USC’s federally funded Alzheimer’s Disease Research Center, according to its website. Zlokovic could not be reached for comment on his leave. DOJ Press Release: Professor Charged for Operating Multimillion-Dollar Grant Fraud Scheme, 28 June 2024 A federal grand jury in the District of Maryland returned an indictment yesterday charging a Penns

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