Into the Impossible With Brian Keating

The Doctor Everyone Mocked — Until His 'Crazy' Theory Wiped Out a Killer Disease. Matt Kaplan - #547

Into the Impossible With Brian Keating

Show Notes

Please join my mailing list here 👉 https://briankeating.com/list to win a meteorite 💥

Matt Kaplan is a science journalist at The Economist and a trained paleontologist. His new book I Told You So!: Scientists Who Were Ridiculed, Exiled, and Imprisoned for Being Right is a candid investigation into how science actually works — and why the engine of discovery is badly in need of a tuneup.

In this conversation, we discuss why the pandemic exposed science's dirty secrets to the public, how Ignaz Semmelweis discovered handwashing saved lives and was thrown in an asylum for it, why Katalin Karikó survived where others didn't, the replication crisis and how funding models are making it worse, whether older scientists should control research dollars, why Galileo was never actually tortured, and what journalists and scientists must do differently before public trust collapses entirely.

Matt Kaplan also recently discussed science communication and dysfunction on other outlets — in this conversation, we go deeper on the replication crisis, the Semmelweis story, and why the funding model is quietly corrupting the scientific process.

🔔 Subscribe for new episodes each week

🎧 Ad-free episodes on Patreon: patreon.com/drbriankeating

INTO THE IMPOSSIBLE — where Nobel Prize winners, physicists, and bold thinkers explore the biggest questions in science.

Key Takeaways

00:00 Why the pandemic was science's most damaging moment of exposure

03:30 The scientific-industrial press complex — and who's really to blame

06:50 How science journalism fails the public 85% of the time

10:00 Ignaz Semmelweis: the man who proved handwashing saves lives and was destroyed for it

20:10 Why infection rates dropped from 21% to zero — and nobody listened

24:30 What Katalin Karikó had that Semmelweis didn't: shelter

28:00 The replication crisis — why nobody is funding the most important work in science

33:00 How funding models force scientists to run experiments they've already won

40:30 Should older scientists control research dollars? A Nobel laureate weighs in

43:45 Why Galileo was never tortured — and why the myth won't die

47:00 The rhinoceros tooth: a paleontologist's lesson in confirmation bias

➡️ Follow Matt Kaplan

🌐 Website: https://www.somuchsciencesolittletime.com/about

📚 I Told You So! Scientists Who Were Ridiculed, Exiled, and Imprisoned for Being Right: https://www.amazon.com/Told-You-Scientists-Ridiculed-Imprisoned/dp/1250372275

✍️ Email: [email protected]

Join this channel to get access to perks like monthly Office Hours: https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join

📚 Get my books: Think Like a Nobel Prize Winner: https://a.co/d/03ezQFu

Focus Like a Nobel Prize Winner: https://a.co/d/hi50U9U

Losing the Nobel Prize: http://amzn.to/2sa5UpA

Dialogue Concerning the Two Chief World Systems (audiobook): https://a.co/d/iZPi9Un

Follow me to ask questions of my guests:

🏄‍♂️ Twitter: https://twitter.com/DrBrianKeating

🔔 Subscribe: https://www.youtube.com/DrBrianKeating?sub_confirmation=1

📝 Mailing list: http://briankeating.com/list

✍️ Blog: https://briankeating.com/blog

🎙️ Audio-only: https://briankeating.com/podcast

#physics #science #sciencejournalism #MattKaplan #briankeating #intotheimpossible Learn more about your ad choices. Visit megaphone.fm/adchoices

More from Into the Impossible With Brian Keating

Oct 20, 2026

Forecasters gave AI under 2% odds of helping solve a millennium-level math problem by September 2026. It happened. Ethan Mollick has been measuring what AI actually does to real work with field experiments, not forecasts, and his answer is not what most people expect. Subscribe if you want science with evidence, not speculation.

Oct 14, 2026

Is there alien technology in our skies, or just birds, balloons and bad video?

Oct 13, 2026

When two people are vibing, their brainwaves synchronize and so do their heartbeats. That is not a metaphor. It is a measurable physiological event, and organizational psychologist Adam Grant has spent his career figuring out how to make it happen on purpose. Subscribe if you want science with evidence, not speculation.

Oct 9, 2026

Roman Yampolskiy says keeping a superintelligence safe forever is as impossible as building a perpetual motion machine. Joscha Bach says today's AI is more controllable than anyone expected, and that shutting it down would doom us anyway.

Oct 7, 2026

The physicist who turned a cubic kilometer of Antarctic ice into a telescope says the most exciting moment of his career was not the discovery. It was the first atmospheric neutrino. Before that, he was deep in debt to NSF and his own university with no neutrino to show for it.

See all episodes →