
CARTA: The Evolution of Powerful Yet Perilous Immune Systems with Andrea Graham
CARTA - Anthropogeny (Audio)Show Notes
Pressures of life on Earth experienced by our ancestors – as multicellular beings, as hosts to parasites, and as home to microbes – shaped the evolved structure and function of our immune systems. Some of the traits favored by natural selection have conferred resistance against infections while opening vulnerabilities to autoimmune diseases. I will illustrate why analysis of the deep-time origins of mammalian immune systems reveals general principles of optimal defense and helps to explain why hosts are so profoundly variable in their susceptibility to infectious and inflammatory diseases. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40692]
More from CARTA - Anthropogeny (Audio)
Ajit Varki, Distinguished Professor in the Departments of Medicine and Cellular & Molecular Medicine, Co-Director of CARTA, and Co-Director of the Glycobiology Research and Training Center at the University of California, San Diego, focuses on a family of cell surface sugars called the sialic acids, and their roles in biology, evolution and disease. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 21987]
Genevieve Konopka is an Assistant Professor of Neuroscience at UT Southwestern Medical Center. The focus of her research is elucidating how developmental signaling pathways are disrupted in neuropsychiatric illnesses, and identifying human-specific pathways that are vulnerable to neuropsychiatric disease. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 21986]
Yoav Gilad is Associate Professor of Human Genetics at the University of Chicago. He studies genetic and regulatory differences between humans and our close evolutionary relatives, with the long-term goal of identifying the genetic basis for human-specific traits, including genetic variation that underlies higher susceptibility to certain diseases and disorders in humans than in other primates. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 21985]
Katherine Pollard, Associate Investigator at the Gladstone Institutes and Associate Professor of Biostatistics at UC San Francisco, specializes in evolutionary genomics, in particular identifying genome sequences that differ significantly between or within species and their relationship to biomedical traits. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 21984]
Alysson Muotri, Assistant Professor at UC San Diego, focuses on human brain development and evolution, exploring mobile elements as generators of neuronal diversity. He is also interested in modeling neurological diseases using human induced pluripotent stem cells. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 21983]