Google’s AI boss made OpenAI issue code red. Now he wants to solve disease. | Titans and Disruptors

Workday cofounder Aneel Bhusri returned to the CEO position for what he calls a “refounding moment.” Bhusri is steering the enterprise software giant toward an AI-native future built around AI agents that may reshape how companies build, hire and manage.

OpenAI CEO Sam Altman sits down with Fortune's Editor-in-Chief Alyson Shontell to discuss the high-stakes balancing act of AI: pushing the boundaries of scientific discovery while confronting the existential risks of loss of control.

Mary Barra has spent more than four decades at General Motors, rising from an 18-year-old co-op student training on the factory floor to CEO. In her 12-year tenure, she’s steered the company through a near-catastrophic safety crisis and helped turn the century-old automaker into an innovation powerhouse that currently ranks No. 23 on the Fortune 500.

Pershing Square Founder and CEO Bill Ackman got his start by cold-calling multi-millionaires and billionaires for startup capital. Today, the billionaire hedge fund manager is a leading voice both on Wall St. and online, where he frequently shares candid opinions about investing, politics, and culture to about 2.7 million X followers.

For the first time in the company's history, FedEx has surpassed UPS in market value. Handling roughly 18 million packages a day, FedEx is acutely aware of how tariffs and geopolitical tensions have disrupted the global supply chain. As it enters its AI era, the company is leveraging artificial intelligence to predict and address these obstacles head-on.