STUMP - Death and Taxes

Research fraud, Alzheimer's, and Mortality trends

STUMP - Death and Taxes

Show Notes

Prominent research in Alzheimer’s disease going back for decades has been found to be fraudulent, which has effects. Alzheimer’s disease has been a cause of death with an increasing age-adjusted death rate, and it’s one of the very few causes of death with a rate that’s higher for females than males (at all ages). How has this come about? And what should be done? STUMP - Meep on public finance, pensions, mortality and more is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

Episode Links Dan Elton from More is Different When "weak links" in science matter -- high profile fraud in Alzheimer's disease research Oct 20, 2024 About a year ago I wrote a post trying to gauge how much of the peer-reviewed literature in non-predatory peer-reviewed journals has deliberate fraud. A number that often comes up is 2%. However, according to forensic metascience expert James Heathers, that number is flawed and out of date. According to a recent review article by Heathers, the true number is likely around 14%. I find many people are either not aware of this issue, or they acknowledge the issue but wave it away as not important.An example is someone who I met recently who works at the National Science Foundation. From their vantage point, fraud is mostly being committed in China, not in the USA, which they described as having far superior systems for grant dispersal and oversight. This is largely true, but it doesn’t mean fraud from the US is not an important issue. One example of retracted article Original article APP binds DR6 to trigger axon pruning and neuron death via distinct caspases Nature, 2009 Feb 19;457(7232):981-9. doi: 10.1038/nature07767. Abstract Naturally occurring axonal pruning and neuronal cell death help to sculpt neuronal connections during development, but their mechanistic basis remains poorly understood. Here we report that beta-amyloid precursor protein (APP) and death receptor 6 (DR6, also known as TNFRSF21) activate a widespread caspase-dependent self-destruction program. DR6 is broadly expressed by developing neurons, and is required for normal cell body death and axonal pruning both in vivo and after trophic-factor deprivation in vitro. Unlike neuronal cell body apoptosis, which requires caspase 3, we show that axonal degeneration requires caspase 6, which is activated in a punctate pattern that parallels the pattern of axonal fragmentation. DR6 is activated locally by an inactive surface ligand(s) that is released in an active form after trophic-factor deprivation, and we identify APP as a DR6 ligand. Trophic-factor deprivation triggers the shedding of surface APP in a beta-secretase (BACE)-dependent manner. Loss- and gain-of-function studies support a model in which a cleaved amino-terminal fragment of APP (N-APP) binds DR6 and triggers degeneration. Genetic support is provided by a common neuromuscular junction phenotype in mutant mice. Our results indicate that APP and DR6 are components of a neuronal self-destruction pathway, and suggest that an extracellular fragment of APP, acting via DR6 and caspase 6, contributes to Alzheimer's disease. Retraction notice Retraction Note: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases The authors have retracted this article1. Our subsequent work confirmed aspects of the article, notably that DR6 and APP interact and function in a genetic pathway involving caspases to control axon pruning and neuron death2,3. However, our later research also showed that certain conclusions reached in the article were incorrect, notably the role of caspase-3, the necessity for beta-secretase enzyme activity for APP-DR6 binding, and the model for the APP-DR6 interaction2,3. More recently, the following anomalies were identified: * Figure 1d: the NGF-deprived +IgG panel appears to be identical to the NGF-deprived, 24h + Control IgG panel of Figure 5e. * Supplementary information Figure 9c: the NG

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Oct 2, 2026

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Jul 11, 2026

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Apr 1, 2026

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Paul Ehrlich died recently at the age of 93, best known as a Malthusian in a modern age of growth and then population decline…with no famines, except man-made ones. His best-known book was The Population Bomb, published in 1968, which was already wrong when it was published. It’s fine to attack the man’s ideas, as they were just plain wrong, he was told this when alive, and he had never admitted this. While not the only person with his ideas, he contributed to the suicide of expertise, by claiming authority in the face of his own falsity.

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