TWiP 275: Novel malaria vector control

TWiP solves the case of the patient who developed an intensely itchy, red papular rash after close contact with chickens and their bedding, where small mites were found. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Hero of the Month: Ogobara Doumbo (Lancet, AJTMH, Lancet) Letters read on TWiP 290 New Case Man in 30s with well controlled diabetes, elevated AST ALT liver tests, asymptomatic. Ultrasound of liver, multiple cysts. Born in rural Yemen, grew up on farm with cattle, sheep, donkeys, 3-4 indoor/outdoor dogs, bathroom inside house, frequently swam in fresh water, as adult worked in construction, 2010 moved to capital, in 2017 Moved to US works in Brooklyn. March 2023 get abnormal lab results. Decide to follow, 1 year later, repeat ultrasound, 3 new lesions 1-2 cm range, triggers abdominal MRI, has enlarged liver 21 cm, hepatic steatosis, cysts. June 2024 has acute right side lower back pain, goes to ED, they say its musculoskeletal. A year later May 2025 goes back to Yemen, develops abdominal discomfort, then resolves.

TWiP explains a single-cell analysis of immune cells in the blood of dogs with canine leishmaniosis, providing a detailed picture of how the immune response changes as the disease progresses. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Single immune cell atlas of canine leishmaniosis (iScience) Clinical staging in CanL (LeishVet) TWiP study – information and survey Become a patron of TWiP Send your questions and comments to [email protected] Music by Ronald Jenkees

TWiP solves the case of the NYC woman in her 30s who developed 3 weeks of significant watery diarrhea after eating at a Taco Bell Restaurant. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 288 Parasite of the month – Parelaphostrongylus tenuis — meningeal worm (brainworm) Wikipedia entry P. tenuis in ruminants (Food Animal Pract) P. tenuis in white-tailed deer (Int J Parasitol Parasites and Wildlife)

Mumtaz Balkhi joins TWiP to discuss phase 1 and 1b trials of the schistosomiasis vaccine SchistoShield which demonstrate that it induces functional immune memory responses in US and African populations. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Guest: Mumtaz Y. Balkhi Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server SchistoShield Phase 1 and 1b results (npj Vaccines) TWiP study – information and survey Become a patron of TWiP Send your questions and comments to [email protected] Music by Ronald Jenkees

TWiP solves the case of the adult female with a 2 year old child who develops anal irritation, but the child and the husband are fine. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 286 Hero – Otto Wucherer TWiP study – information and survey New Case Recent case. Woman in 20s, lives in NYC, goes to urgent care with 3 weeks of significant watery diarrhea, not improving. Otherwise healthy, no travel, works in office in NYC, at some point prior to onset she ate at a Taco Bell. Put on twice a day medication, molecular test of stool confirms diagnosis. Don't know when, or what she ate. Trying to replenish fluid losses. Not immunosuppressed. Become a patron of TWiP Send your questions and comments to [email protected] Music by Ronald Jenkees