
Long COVID Is More Than One Illness - The Hidden Biological Patterns Driving Chronic Symptoms with Dr. Christian Jenski | Long COVID | E165
Made for Health | Peptides | Lyme | Chronic Infections | Long Covid | Insulin Resistance | HypermobilityShow Notes
🔥 What if Long COVID isn’t one condition, but a collection of biological processes keeping your body stuck in survival mode long after the infection is gone? Read UnCurable (https://uncurablebook.com/) to explore how chronic illness can involve the immune system, mitochondria, inflammation, and the body’s ability to recover. Why Long COVID Can Trigger Brain Fog, Fatigue, and Autoimmunity: The Hidden Biology Behind Persistent Symptoms In this episode of Made for Health, Dr. Aaron Hartman welcomes back Dr. Christian Jenski to continue their deep dive into Long COVID and the complex biological mechanisms that may keep symptoms going long after the initial infection. Rather than viewing Long COVID as a single condition, they explain why it may represent multiple overlapping processes involving chronic inflammation, immune dysregulation, mitochondrial dysfunction, mast cell activation, nervous system changes, and persistent cellular stress. Dr. Hartman and Dr. Jenski discuss how functional and integrative medicine approaches complex illnesses by identifying patterns across multiple body systems instead of focusing on isolated symptoms. They explore the science behind Mast Cell Activation Syndrome (MCAS), Chronic Inflammatory Response Syndrome (CIRS), the Cell Danger Response, mitochondrial dysfunction, senescent cells, autophagy, autoimmunity, and nervous system dysregulation. Throughout the conversation, they emphasize that understanding which mechanisms are driving an individual's symptoms is essential for creating a personalized treatment strategy under the guidance of an experienced clinician. Key Topics Covered Why Long COVID may involve multiple overlapping biological processes How functional medicine approaches complex chronic illness through systems biology Mast Cell Activation Syndrome (MCAS) and persistent inflammation Why mast cells can contribute to fatigue, brain fog, digestive symptoms, skin issues, and pain Chronic Inflammatory Response Syndrome (CIRS) and biotoxin illness How environmental exposures may contribute to chronic inflammation Mitochondrial dysfunction and the Cell Danger Response Why cells can become "stuck" in survival mode Senescent ("zombie") cells and chronic immune activation The roles of autophagy and apoptosis in healthy cellular turnover Understanding DAMPs and PAMPs in chronic immune signaling How persistent inflammation may contribute to autoimmunity Nervous system dysregulation and limbic retraining Why personalized testing and clinical oversight are important when evaluating Long COVID
In This Episode, You Will Learn ✅ Why Long COVID may involve much more than a lingering viral infection ✅ How mast cell activation can contribute to a wide variety of persistent symptoms ✅ The connection between chronic inflammation, mitochondrial dysfunction, and fatigue ✅ Why damaged cells may continue sending inflammatory signals long after an illness ✅ How chronic immune activation may contribute to autoimmune conditions ✅ Why functional medicine focuses on identifying each patient's unique combination of biological drivers Follow Dr. Aaron Hartman and Richmond Integrative & Functional Medicine 🌐 Website: https://richmondfunctionalmedicine.com/ 📺 YouTube: @AaronHartmanMD Mentioned in this episode: 25% Off Back to School Support for Parents Back to school asks a lot of parents, too. Support your body through the season with three physician-reviewed, foundation-first essentials: Twice Daily Multi, Quercetin + Nettles, and NAC. For a limited time, save 25% on the Back to School Support Bundle. Visit the link below ⬇️ Shop the Back to School Sale Back to School Support for Parents 25% Off Back to School Support for Parents Back to school asks a lot of parents, too. Support your body through the season with three physician-reviewed, foundation-first essentials: Twice Daily Multi, Quercetin + Nettles, and NAC. For a limited time, save 25% on the Back to School Support Bundle. Visit the link below ⬇️ Shop the Bac
More from Made for Health | Peptides | Lyme | Chronic Infections | Long Covid | Insulin Resistance | Hypermobility
🎒 Back-to-school season brings changing routines, new exposures, and added demands on the whole family. Support your family’s health this season with Richmond Integrative & Functional Medicine’s Back-to-School 2026 resources. Back-to-School 2026: https://richmondfunctionalmedicine.com/lp/back-to-school-2026/ In this Made for Health solo minisode, Dr. Aaron Hartman continues asking the question at the center of this series: Why are you still sick? Why are you stuck even after addressing Lyme disease, mold, MCAS, gut dysfunction, nervous-system dysregulation, and other potential drivers? This time, Dr. Hartman looks at something much more fundamental: Are you actually getting—and using—the nutrients your cells need? He explores thiamine, or vitamin B1, deficiency, including the possibility of milder functional deficiencies that may not resemble classic severe beriberi but could still overlap with symptoms such as fatigue, neurological complaints, dysautonomia, and POTS. He then expands the conversation to a larger concept: high-calorie malnutrition, where someone may consume plenty of calories while still being deficient in vitamins, minerals, and other micronutrients required for normal cellular energy production. For Dr. Hartman, this raises another important possibility for people who have made progress but still feel stuck: What if part of the problem is not another disease—but a body that simply does not have enough of the raw materials it needs to function well? Key Topics Covered Why nutrient deficiencies may be overlooked in chronic illness Thiamine, or vitamin B1, deficiency Functional versus severe nutrient deficiency Wet and dry beriberi Thiamine and neurological function Thiamine and cardiovascular function Dysautonomia and POTS Chronic fatigue and fibromyalgia Mitochondrial dysfunction Cellular energy production Why some patients may respond to B1 supplementation The concept of high-calorie malnutrition Processed food and micronutrient density B-vitamin deficiencies Magnesium and potassium Vitamin D Omega-3 fatty acids Micronutrients and the Krebs cycle Why calories alone do not equal nutrition Food fortification and nutrient loss from food processing IV vitamin C and the additional nutrients often included with it B-complex vitamins Nutrient testing in complex chronic illness Why rebuilding nutrient status may take time Returning to foundational nutrition and real food
🎒 Back-to-school season brings changing routines, new exposures, and added demands on the whole family. Support your family’s health this season with Richmond Integrative & Functional Medicine’s Back-to-School 2026 resources. Back-to-School 2026: https://richmondfunctionalmedicine.com/lp/back-to-school-2026/ What if cancer is not simply an isolated enemy to attack, but also a signal to look more closely at the terrain in which disease developed? In this powerful episode of Made for Health, Dr. Aaron Hartman sits down with Dr. Nasha Winters, ND, FABNO, L.Ac, Dipl.OM, a naturopathic doctor and Fellow of the American Board of Naturopathic Oncology whose work focuses on metabolic and integrative oncology. Dr. Winters’ interest in cancer is deeply personal. At just 19 years old, after years of unexplained health problems, she was diagnosed with advanced ovarian cancer involving multiple areas of her body and was told she may have only months to live. That experience ultimately redirected her education, clinical career, and understanding of health. Pasted text(20261018-195841) More than three decades later, she shares how that diagnosis changed the way she thinks about cancer, trauma, metabolism, environmental exposures, mitochondria, hormones, and the relationship between a person's biography and biology. Key Topics Covered Dr. Nasha Winters’ stage IV ovarian cancer diagnosis at age 19 Why her early symptoms were repeatedly attributed to existing diagnoses What changed when one physician recognized that something was different Her prognosis and the moment she decided she wanted to understand cancer rather than simply “fight” it The unexpected experiences she believes influenced her early survival Fasting and metabolic stress in cancer Childhood trauma and the Adverse Childhood Experiences, or ACE, framework Big-T and little-T trauma EMDR and trauma processing Psychedelic experiences and confronting mortality Psychoneuroimmunology The relationship between emotions, stress, nervous-system signaling, and physical health Cancer as a disease of the individual “terrain” Environmental exposures and the exposome Mitochondrial health Metabolic dysfunction and cancer Insulin and growth signaling Hormone metabolism Integrative approaches to prostate cancer Integrative considerations in breast cancer Colon cancer and the rising burden of cancer in younger adults Why Dr. Winters believes patients should understand their individual terrain How integrative oncology can work alongside conventional cancer care Why patients may have more influence over their health than they realize
🎒 Back-to-school season brings changing routines, new exposures, and added demands on the whole family. Support your family’s health this season with Richmond Integrative & Functional Medicine’s Back-to-School 2026 resources. Back-to-School 2026: https://richmondfunctionalmedicine.com/lp/back-to-school-2026/ In this Made for Health solo minisode, Dr. Aaron Hartman continues his ongoing series asking a deceptively simple question: Why are you still sick? Why does your body seem stuck even after you’ve addressed so many other pieces? After years of working with patients dealing with mold illness, Lyme disease, autoimmune issues, gut dysfunction, SIBO, hormonal problems, brain fog, mast-cell activation, and other complex conditions, Dr. Hartman says one pattern increasingly stands out: the nervous system itself may remain dysregulated even after other contributors have been addressed. Pasted text This episode explores what he calls a nervous-system triad involving limbic-system dysregulation, mast-cell activation, and vagal dysfunction, along with trauma, multiple chemical sensitivity, the “cell danger response,” and why some patients paradoxically feel worse when given treatments that seem biochemically appropriate. Pasted text The central idea is not that chronic illness is “all in your head.” It is almost the opposite: your brain, nervous system, immune system, mitochondria, and stress-response pathways may all be communicating with one another—and sometimes the body has difficulty returning to a state that feels safe enough for recovery. Key Topics Covered Why nervous-system dysregulation may keep some chronically ill patients feeling stuck Why “it’s all in your head” can be a damaging oversimplification Big-T trauma, little-T trauma, and healthcare-related trauma Limbic-system hypervigilance The amygdala, memory, emotion, and threat perception Multiple Chemical Sensitivity and TILT Mast Cell Activation Syndrome as part of the nervous-system picture Vagal dysfunction and autonomic regulation Fight, flight, freeze, shutdown, and overwhelm Polyvagal concepts discussed in the episode Chronic stress and the body’s sense of safety The “cell danger response” framework Mitochondria and inflammatory signaling Why some patients feel worse from supplements or detoxification protocols Reactions to glutathione, methyl donors, and other treatments discussed in the episode Brain retraining and nervous-system regulation EMDR, somatic therapy, parts work, breathwork, and tapping Why trauma work may sometimes need to happen earlier in the healing process Why foundational work involving stress, sleep, environment, and nervous-system regulation still matters
🎒 Back-to-school season brings changing routines, new exposures, and added demands on the whole family. Support your family’s health this season with Richmond Integrative & Functional Medicine’s Back-to-School 2026 resources. Back-to-School 2026: https://richmondfunctionalmedicine.com/lp/back-to-school-2026/ In this deeply personal episode of Made for Health, Dr. Aaron Hartman sits down with Dr. Efrat “Dr. E” LaMandre, a family nurse practitioner, PhD in Integrative Medicine, host of the Medical Disruptor podcast, and a leading voice on medical gaslighting. What begins as a conversation about why patients feel dismissed when their tests come back “normal” becomes something much more personal. Dr. E shares that she was recently diagnosed with stage IV lung cancer after months of back pain that she repeatedly minimized herself. The experience transformed her from a clinician who teaches patient advocacy into a patient navigating the healthcare system firsthand. Pasted text Together, Dr. Hartman and Dr. E explore a rarely discussed side of medical gaslighting: the ways patients can begin gaslighting themselves. We may apologize for taking a clinician’s time, downplay symptoms, assume normal tests mean nothing is wrong, or ignore the internal sense that something has changed. Their message is not to reject conventional medicine. It is to understand what each clinician can and cannot provide, continue investigating when symptoms persist, and build a healthcare team capable of looking at the whole picture. Key Topics Covered What medical gaslighting actually means Why normal laboratory results do not automatically mean a patient feels well Why patients may feel dismissed even by well-intentioned clinicians Populations most affected by medical gaslighting Why women may be especially likely to minimize their symptoms Fatigue, migrating pain, unusual sensations, and GI complaints that can be difficult to fit into conventional diagnostic categories The habit of “pre-apologizing” before describing symptoms How patients learn to become “good patients” Why people sometimes trust test results more than their own bodily experience Intuition as a form of pattern recognition The importance of knowing when something is different from your normal Why self-advocacy does not mean rejecting doctors Understanding the limitations of individual medical specialties Why conventional testing still matters How to build a multidisciplinary healthcare team Choosing clinicians and researchers over unqualified health advice Avoiding overwhelm when facing a complex diagnosis Why healing plans may need to be implemented gradually The emotional and mental challenges of serious and chronic illness Hope, family, purpose, and continuing to move forward
🎒 Back-to-school season brings changing routines, new exposures, and added demands on the whole family. Support your family’s health this season with Richmond Integrative & Functional Medicine’s Back-to-School 2026 resources. Back-to-School 2026: https://richmondfunctionalmedicine.com/lp/back-to-school-2026/ In this Made for Health minisode, Dr. Aaron Hartman continues exploring an important question: Why are you still sick? Why does your body seem unable to get back into a healing state? This time, he focuses on dysautonomia and POTS—Postural Orthostatic Tachycardia Syndrome—conditions involving dysfunction in the autonomic nervous system, which helps regulate processes such as heart rate, blood pressure, temperature, digestion, sleep, and the body's response to stress. Pasted text For some people, the signs are dramatic. For others, they can be subtle: feeling lightheaded when standing, experiencing a racing or pounding heart seemingly out of nowhere, waking suddenly at night, struggling with brain fog, cold hands and feet, unusual skin color changes, temperature intolerance, or simply feeling significantly better after fluids, electrolytes, compression, or time spent calming the nervous system. Pasted text Dr. Hartman explains why dysautonomia can easily become one more overlooked layer in complex chronic illness—and why identifying what originally disrupted the nervous system may be just as important as identifying POTS itself. Key Topics Covered What dysautonomia means What POTS is and how it relates to dysautonomia The sympathetic and parasympathetic nervous systems Lightheadedness and dizziness after standing Heart racing and unexplained palpitations Brain fog and difficulty thinking Waking at night with a racing heart Cold hands and feet Changes in skin color and circulation Problems regulating body temperature Sleep, mood, hormonal, and gastrointestinal symptoms Why mild dysautonomia may be overlooked Fluids and electrolytes Compression garments Nervous-system regulation Dysautonomia after concussion or head injury Long COVID and post-infectious dysautonomia Lyme disease and nervous-system dysfunction Hypermobility and POTS Mast Cell Activation Syndrome Autoimmune and gastrointestinal overlap Why the patient's history can guide treatment The NASA Lean Test Physical examination findings Dr. Hartman considers Why treating the underlying trigger matters