
CARTA: Is There a Point to Periods? The Evolutionary History of Menstruation and Implications of Women's Health with Deena Emera
CARTA - Anthropogeny (Audio)Show Notes
Menstruation is the cyclical shedding of the endometrium triggered by falling progesterone levels. Menstruation is a rare trait found in less than 2% of mammals and likely evolved independently at least 4 times. Why do some mammals menstruate while most do not? The leading hypothesis is that menstruation occurs as a nonadaptive consequence of spontaneous decidualization of the endometrium, which evolved to increase biosensoring of embryo quality. While the trait of spontaneous decidualization (and as a byproduct, menstruation) was likely shaped by natural selection, menstruation also disposes women to conditions such as endometriosis, pre-menstrual syndrome, and bleeding disorders, especially in the contemporary context. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Humanities] [Science] [Show ID: 40693]
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Ajit Varki, Distinguished Professor in the Departments of Medicine and Cellular & Molecular Medicine, Co-Director of CARTA, and Co-Director of the Glycobiology Research and Training Center at the University of California, San Diego, focuses on a family of cell surface sugars called the sialic acids, and their roles in biology, evolution and disease. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 21987]
Genevieve Konopka is an Assistant Professor of Neuroscience at UT Southwestern Medical Center. The focus of her research is elucidating how developmental signaling pathways are disrupted in neuropsychiatric illnesses, and identifying human-specific pathways that are vulnerable to neuropsychiatric disease. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 21986]
Yoav Gilad is Associate Professor of Human Genetics at the University of Chicago. He studies genetic and regulatory differences between humans and our close evolutionary relatives, with the long-term goal of identifying the genetic basis for human-specific traits, including genetic variation that underlies higher susceptibility to certain diseases and disorders in humans than in other primates. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 21985]
Katherine Pollard, Associate Investigator at the Gladstone Institutes and Associate Professor of Biostatistics at UC San Francisco, specializes in evolutionary genomics, in particular identifying genome sequences that differ significantly between or within species and their relationship to biomedical traits. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 21984]
Alysson Muotri, Assistant Professor at UC San Diego, focuses on human brain development and evolution, exploring mobile elements as generators of neuronal diversity. He is also interested in modeling neurological diseases using human induced pluripotent stem cells. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 21983]