745: Why You’re Wired, Tired, and Awake at 3AM (And What to Do About It) with Dr. Scott Sherr

Why are so many women waking up exhausted… but unable to shut their brain off?”

In this episode, Dr. Mariza sits down with Scott Sherr to unpack the hidden nervous system and biochemical shifts driving sleep struggles, anxiety, exhaustion, and feeling “wired and tired” in midlife.

Together, they explore why women in perimenopause often lose stress resilience, why the brain gets stuck in overdrive at night, and how neurotransmitters like GABA, serotonin, adenosine, and cortisol shape sleep quality, recovery, and mood.

They also dive into the powerful connection between mitochondrial health, nervous system regulation, energy production, and why building more “reserve” may be the missing key to feeling calm, focused, and resilient again.

If you’ve been struggling with middle-of-the-night wakeups, burnout, anxiety, or feeling like your brain never truly powers down, this episode will help connect the dots—and offer practical solutions that actually move the needle.

Dr. Scott Sherr

Dr. Scott Sherr is a physician, health optimization expert, and Chief Operating Officer of Troscriptions. His work focuses on nervous system regulation, mitochondrial health, hyperbaric medicine, sleep optimization, and performance medicine. He is passionate about helping people improve resilience, energy, recovery, and cognitive performance through science-backed strategies and targeted support.

IN THIS EPISODE

Why so many women feel “wired and tired” in perimenopause

The real reason behind 2–3 AM wakeups and racing thoughts

How GABA, cortisol, serotonin, and adenosine impact sleep and stress

Why nervous system regulation is essential for resilience and recovery

The connection between mitochondrial health, energy, and brain function

How chronic stress and sympathetic overload affect hormones and mood

Practical tools to support sleep, focus, calm, and nervous system balance

QUOTES

“Sleep will make or break you the next day—especially in this season of life.”

“To increase your performance is having more reserve.”

“You’re not meant to live in a state of disruption, exhaustion, and feeling wired and tired all the time.”

RESOURCES MENTIONED

Use code ENERGIZED and get 10% off on your Troscription Order

http://troscriptions.com/ENERGIZED

Use code ENERGIZED and get 10% off on your MitoQ Order

https://www.mitoq.com/energized%C2%A0

Troscriptions Website

Dr. Scott Sherr Instagram

Dr. Scott Sherr Youtube

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