I’ve Been A Cardiovascular Scientist For 30 Years… ED Is A Warning Sign of Heart Disease

Dr. Matt Kaeberlein is a biologist of aging, the CEO of Optispan, and a co-founder of the Dog Aging Project. He is also the founding director of the University of Washington’s Healthy Aging and Longevity Research Institute and has published over 250 papers on longevity. In this conversation, he breaks down why direct-to-consumer longevity products deserve skepticism, what the data actually says about rapamycin and intermittent fasting, and which biomarkers and scans are worth your money. In this episode, we discuss: (1:58) Why Matt Kaeberlein Resigned From a Longevity Academy in 2024 (9:14) How to Spot Longevity Hype and Misleading Supplement Claims (16:31) Lifespan vs. Healthspan: Have We Really Slowed Aging? (22:01) Curing Cancer Adds 2.5 Years. Slowing Aging Could Add 20. (24:43) Should Aging Be Classified as a Disease? (30:59) The Hallmarks of Aging Explained (39:39) Is VO2 Max the Best Longevity Metric? (47:29) The Intermittent Fasting Myth: What Mouse Studies Show (51:38) What Is Rapamycin and Does It Slow Aging? (58:00) Inside the Dog Aging Project’s Rapamycin Trial (1:01:19) Does Matt Kaeberlein Recommend Rapamycin? (1:04:37) Protein Maxing and mTOR: Does More Protein Speed Aging? (1:11:54) Are Biological Age Tests Accurate? (1:19:49) The One Biological Age Clock He Trusts: LinAge2 (1:24:29) Best Longevity Spend: $100 vs. $1,000 a Month

Dr. Catherine Salmon is a Professor of Psychology at the University of Redlands and an evolutionary psychologist who has spent over two decades studying erotic fiction, pornography, and female sexuality. She's the co-author of Warrior Lovers: Erotic Fiction, Evolution and Female Sexuality and The Secret Power of Middle Children, and her research explores what romance novels and porn — the private products billions of people consume — reveal about the evolved mating psychology of men and women. In this episode, we discuss:

TRIGGER WARNING: Discussions of suicide and depressionIf anyone watching is personally struggling, the 988 Suicide & Crisis Lifeline (call or text 988 in the US) is always available.

Christopher Gardner, PhD, is a nutrition scientist and Professor of Medicine at Stanford University, where he has led more than 20 large-scale randomized clinical trials comparing diets like keto, vegan, low-fat, and low-carb. He's the past chair of the American Heart Association's Nutrition Committee and the author of the upcoming book Food Sense, which argues there's far more scientific consensus about what to eat than the internet's diet wars would suggest. In this episode, we discuss:

Dr. Neha Sangwan is an internal medicine physician turned communication and burnout expert, and the founder and CEO of Intuitive Intelligence. After burning out herself early in her medical career, she spent the next 20 years studying the physiology of stress and now coaches leaders at companies like Google, Apple, and American Express on how to have honest conversations and read their body's signals before they hit a breaking point. She's the author of Talk Rx and Powered by Me, and has spoken on three TEDx stages. In this episode, we discuss: