Show Notes
What is happening in agriscience today that we will be talking about 100 years from now? While it’s impossible to answer that question with certainty, there is a technology that has the potential to impact our industry in the next century as much or even more than hybridization changed the game over the past century. That technology is genome editing. The promise of this technology is very real and today you’re going to hear firsthand accounts of what changed in 2012 and 2013 to make all of this possible, what did it look like to test the technology in plant breeding, and what does the strategy look like to turn this science into better solutions.
“In 2012, we had the seminal paper from Jennifer Doudna, and the entire scientific community was getting very excited with how we could use a technology like CRISPR gene editing to precisely rewrite DNA to get to the end outcome that we want much faster than before… The question we were asking in Pioneer was, yes, we have the technology, and every week you see new improvements in efficiencies of the technology, but where do you apply it?” - Nandini Krishnamurthy, Ph.D.
In this episode, we go behind the scenes to peek into how genome editing arrived on the scene in agriculture, where it stands currently, and why many scientists are calling it a revolutionary technology. Joining us are two people that have been a part of the emergence of CRISPR, the powerful tool that enables scientists to edit the DNA of living organisms. Dr. Nandini Krishnamurthy is the director of external technologies and gene editing ecosystem development at Corteva Agriscience. She has a background in genetics and cell biology and after finishing her PhD at Texas A&M, she focused on computational biology. Also joining us is Dr. Neal Gutterson. Gutterson has a background in executive leadership with biotechnology companies and joined Pioneer in 2014 as the vice president of research and development. He was instrumental in laying the groundwork for genome editing in plant breeding.
“ To be able to fashion the strategy around how we would use and deploy genome editing in, you know, biotech/breeding, but then also how we position it in terms of the marketplace and farmers and other companies seemed like an incredible opportunity. ” - Neal Gutterson, Ph.D.
By proving the concept, communicating with the public and allowing access to the technology, a lot of the groundwork for gene editing in agriculture was already starting to be formed. However, the big question many of you still may be wondering is: what do the farmers think of this? For this we’ll turn back to the farmer we featured on episode 28 of this podcast: Corey Loesson. And while he doesn’t speak for all farmers, it’s safe to assume it echoes the perspective of many if not most out there.
“ We're really talking about accelerated plant breeding, which plant breeding has been going on since agriculture started really, you know, centuries. And we're just getting better at it. And that better part enables us to produce food more efficiently ultimately. ” - Corey Loesson
A few takeaways from this episode: This technology is revolutionary and it’s here. There is a strong case to be made that with the right regulatory framework, this could be every bit as game-changing in the next century as hybridization was in the past century. This is not GMO 2.0 - it’s advanced breeding. These are two distinctly different approaches, but we also have some lessons learned from transgenics with regards to communication and engagement that I think will be important for the emergence of this biotechnology in crops. While farmers are not growing gene edited crops today, there has already been tremendous progress made toward utilizing this technology for their benefit. The difference between cooking a meal and serving it as Nandini said. We truly are at the end of the beginning and ready to enter this next chapter of commercially available gene edited crops. Agriscience
More from Agriscience Explained
Please send us your feedback on the podcast: [email protected] In this episode, we look back on the past 100 years, and highlight what will carry over into this next chapter in the company’s history. Corteva Agriscience chief technology and digital officer Sam Eathington and some really special guests discuss the past, present and future of agriscience innovation.
Dr. Carla Yerkes joins us to help us tell the story of Rinskor and explain the process of herbicide innovation and the persistence and creativity it takes to develop new solutions for farmers. Yerkes is a research biologist at Corteva Agriscience and has a Ph.D. in herbicide physiology. She has spent about half of her 30 year career in herbicide discovery research and the other half in herbicide trait discovery.
In today’s episode, we’re following a molecule around the world, from being discovered in Japan to being developed in the United States to becoming a solution for farmers in the United Kingdom. Joining us is one of those farmers in the UK, Julian Gibbons. Julian has seen a variety of fungicide solutions come and go for important wheat diseases like Septoria tritici, or speckled leaf blotch. He’s really excited about the potential for a relatively newly registered product derived from a natural compound called Inatreq Active™. And the story of the need for Inatreq and the road to getting this product to farmers is the focus of today’s episode.
We celebrate the 100th year anniversary of Pioneer Seeds, and take a look back at the history of hybridization. The process may seem simple: to take two varieties or even species and cross them together to create more desirable offspring. But the concept of controlled hybridization, intentionally transferring pollen from a chosen male parent to a chosen female parent, is relatively new in the history of agriculture. But it has been nothing short of revolutionary.
What does it take to break the world soybean yield record? Today we talk to soybean yield record-holder Alex Harrell and soybean breeder Don Kyle. Alex farms in southwest Georgia with his dad where they primarily grow soybeans, corn, wheat and watermelon. In 2023, he became the first farmer to record a soybean yield of over 200 bushels per acre. The next year he beat his own record coming in at 218.2856 bushels per acre. It’s an incredible achievement for anyone, but it’s even more impressive when you consider that Alex farms in an area that doesn’t generally grow a lot of soybeans. “ We did a lot of studying, a lot of class, made a lot of mistakes, and watched a lot of beans rot in our humidity. You know when the things do line up, we have a lot of yield potential there as well. ” - Alex Harrell Farmers like Alex have had to learn these lessons and refine their system over years while experimenting with and matching up the right genetics for their fields. Don Kyle became interested in soybean breeding in the early 90s and has since dedicated his career in plant breeding to the crop. Today he’s a soybean breeder and Evaluation Zone Lead for the Eastern US at Corteva Agriscience based in Princeton, Illinois. He says even though he’s focused on soybeans for over 30 years, he’s more passionate than ever about the crop. Don thinks we might see more hybrid soybeans in the future, similar to what we’re currently seeing with wheat. But for now, farmers aren’t using hybrid soybeans so it’s even more impressive what farmers like Alex Harrell have been able to achieve in terms of yield growth over the years. “ It's very easy to produce soybean seed because they self-pollinate themselves. The problem is to produce hybrid seed is really difficult. So making a cross between two different soybean varieties today still requires using tweezers and sometimes magnifying glasses so you could see the flower parts the best. It's a very tedious job.” - Don Kyle A few takeaways from this episode: