Show Notes
We’ve already learned a lot about electrophilic aromatic substitution (EAS) and benzene, but guess what? There’s even more to learn! In this episode of Crash Course Organic Chemistry we’ll revisit our old friends the Friedel-Crafts reactions and learn some of their limitations and look at where substitution happens when there are multiple directing groups on a benzene ring. Plus we’ll introduce some benzylic reactions!Episode Sources:Master Organic Chemistry: Reactions on the “Benzylic” Carbon: Bromination And OxidationIndigo – Ben Valsler, Chemistry WorldTravis, A.S. (2009). Anilines: Historical Background. In PATAI'S Chemistry of Functional Groups, Z. Rappoport (Ed.). https://doi.org/10.1002/9780470682531.pat0383Master Organic Chemistry: EAS Reactions (3) – Friedel-Crafts Acylation and Friedel-Crafts AlkylationSolomons, G.T. and Fryhle, C.B. (2011) Organic Chemistry. 10th Edition, John Wiley & Sons, Inc., Hoboken.Series Sources:Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, Boston, 2018.Bruice, P. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., United States, 2014.Clayden, J., Greeves, N., Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, New York, 2012.Jones Jr., M.; Fleming, S. A., Organic Chemistry, 5th ed.; W. W. Norton & Company, New York, 2014. Klein., D., Organic Chemistry; 1st ed.; John Wiley & Sons, United States, 2012.Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publishers, Colorado, 2009.McMurry, J., Organic Chemistry, 9th ed.; Cengage Learning, Boston, 2016.Smith, J. G., Organic chemistry; 6th ed.; McGraw-Hill Education, New York, 2020.Wade., L. G., Organic Chemistry; 8th ed.; Pearson Education, Inc., United States, 2013.***Watch our videos and review your learning with the Crash Course App! Download here for Apple Devices: https://apple.co/3d4eyZoDownload here for Android Devices: https://bit.ly/2SrDulJCrash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourseThanks to the following patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:DL Singfield, Jeremy Mysliwiec, Shannon McCone, Amelia Ryczek, Ken Davidian, Brian Zachariah, Stephen Akuffo, Toni Miles, Oscar Pinto-Reyes, Erin Nicole, Steve Segreto, Michael M. Varughese, Kyle & Katherine Callahan, Laurel A Stevens, Vincent, Michael Wang, Stacey Gillespie, Jaime Willis, Krystle Young, Michael Dowling, Alexis B, Rene Duedam, Burt Humburg, Aziz Y, DAVID MORTON HUDSON, Perry Joyce, Scott Harrison, Mark & Susan Billian, Junrong Eric Zhu, Alan Bridgeman, Rachel Creager, Jennifer Smith, Matt Curls, Tim Kwist, Jonathan Zbikowski, Jennifer Killen, Sarah & Nathan Catchings, Brandon Westmoreland, team dorsey, Trevin Beattie, Divonne Holmes à Court, Eric Koslow, Jennifer Dineen, Indika Siriwardena, Khaled El Shalakany, Jason Rostoker, Shawn Arnold, Siobhán, Ken Penttinen, Nathan Taylor, William McGraw, Andrei Krishkevich, ThatAmericanClare, Rizwan Kassim, Sam Ferguson, Alex Hackman, Jirat, Katie Dean, neil matatall, TheDaemonCatJr, Wai Jack Sin, Ian Dundore, Matthew, Justin, Jessica Wode, Mark, Caleb Weeks__Want to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashCourseTwitter - http://www.twitter.com/TheCrashCourseTumblr - http://thecrashcourse.tumblr.com Support Crash Course on Patreon: http://patreon.com/crashcourseCC Kids: http://www.youtube.com/crashcoursekids Learn more about your ad choices. Visit megaphone.fm/adchoices
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If you’ve been paying attention to the news since, oh, say, 2020, then you’ll no doubt be aware that public health policy can often create tension. Having policies that affect public health can, and does, save lives, but not all policies affecting our health are “health policies.” Don’t worry, we’re going to break it all down in this episode of Crash Course Public Health, where we will discuss how an orthopedic surgeon’s love of racing helped create seatbelt policies in the US, and why sometimes laws governing what can be built where affect our health. Chapters: Seat Belts & Your Health 00:00Understanding Health & Policy 2:21Vaccination Policies 4:40How Policies Save Lives 6:42Who Makes Health Policy? 10:01Review & Credits 12:33Check out our shared playlist with APHA: https://www.youtube.com/playlist?list=PLDjqc55aK3kywF2dd97_Jh5iP0d2ARhdo Vanessa’s channel: https://www.youtube.com/braincraft Sources: https://docs.google.com/document/d/1OHJiQ1njj5jWJC1YLDBzQgKC1QfnVgqJbbpK6qs7ekA/edit?usp=sharing***Crash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourseThanks to the following patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:Dylan Mandelblatt, Katie, Hilary Sturges, Austin Zielman, Tori Thomas, Justin Snyder, Hasan Jamal, DL Singfield, Amelia Ryczek, Ken Davidian, Stephen Akuffo, Toni Miles, Steve Segreto, Kyle & Katherine Callahan, Laurel Stevens, Michael Wang, Stacey J, Burt Humburg, Allyson Martin, Aziz Y, Shanta, DAVID MORTON HUDSON, Perry Joyce, Scott Harrison, Mark & Susan Billian, Alan Bridgeman, Rachel Creager, Breanna Bosso, Matt Curls, Tim Kwist, Jonathan Zbikowski, Jennifer Killen, Sarah & Nathan Catchings, team dorsey, Trevin Beattie, Eric Koslow, Jennifer Dineen, Indika Siriwardena, Jason Rostoker, Shawn Arnold, Siobhán, Ken Penttinen, Nathan Taylor, Les Aker, William McGraw, ClareG, Rizwan Kassim, Constance Urist, Alex Hackman, Jirat, Pineapples of Solidarity, Katie Dean, Wai Jack Sin, Ian Dundore, Justin, Mark, Caleb Weeks__Want to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashCourseTwitter - http://www.twitter.com/TheCrashCourseInstagram - https://www.instagram.com/thecrashcourse/CC Kids: http://www.youtube.com/crashcoursekids Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode of Crash Course Psychology, Hank has a look at that oh-so-troublesome time in everyone's life: Adolescence! He talks about identity, individuality, and The Breakfast Club. Want more videos about psychology? Check out our sister channel SciShow Psych at https://www.youtube.com/scishowpsych! --Chapters:Introduction: The Breakfast Club 00:00Erikson's 8 Stages of Progressive Psychosocial Development 2:05Adolescence: Identity vs. Role Confusion 2:51Young Adulthood: Intimacy vs. Isolation 3:39Middle Adulthood: Generativity vs. Stagnation 4:35Late Adulthood: Integrity vs. Despair 5:10Physical Changes in Adulthood 5:57Fluid & Crystallized Intelligence 6:50Dementia & Alzheimer's Disease 8:10Review & Credits 9:25--Crash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourseWant to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashCourseTwitter - http://www.twitter.com/TheCrashCourseInstagram - https://www.instagram.com/thecrashcourse/CC Kids: http://www.youtube.com/crashcoursekids Learn more about your ad choices. Visit megaphone.fm/adchoices
Disease doesn’t care about national borders. The pathogen hopping the red eye from Berlin to Boston doesn’t need a passport. So, in order to be proactive about protecting our health, we need to think globally. In this episode of Crash Course Public Health, we’re traveling around the world to look struggles and triumphs of public health on a global scale.Chapters: Introduction to Global Health 00:00The WHO 2:15Communicable Disease 3:26Non-communicable Disease 6:11Foreign Aid 8:33Economic Inequality 11:57Review & Credits 14:18Check out our shared playlist with APHA: https://www.youtube.com/playlist?list=PLDjqc55aK3kywF2dd97_Jh5iP0d2ARhdo Vanessa’s channel: https://www.youtube.com/braincraft Sources: https://docs.google.com/document/d/1OHJiQ1njj5jWJC1YLDBzQgKC1QfnVgqJbbpK6qs7ekA/edit?usp=sharing***Crash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourseThanks to the following patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:Dylan Mandelblatt, Katie, Hilary Sturges, Austin Zielman, Tori Thomas, Justin Snyder, Hasan Jamal, DL Singfield, Amelia Ryczek, Ken Davidian, Stephen Akuffo, Toni Miles, Steve Segreto, Kyle & Katherine Callahan, Laurel Stevens, Michael Wang, Stacey J, Burt Humburg, Allyson Martin, Aziz Y, Shanta, DAVID MORTON HUDSON, Perry Joyce, Scott Harrison, Mark & Susan Billian, Alan Bridgeman, Rachel Creager, Breanna Bosso, Matt Curls, Tim Kwist, Jonathan Zbikowski, Jennifer Killen, Sarah & Nathan Catchings, team dorsey, Trevin Beattie, Eric Koslow, Jennifer Dineen, Indika Siriwardena, Jason Rostoker, Shawn Arnold, Siobhán, Ken Penttinen, Nathan Taylor, Les Aker, William McGraw, ClareG, Rizwan Kassim, Constance Urist, Alex Hackman, Jirat, Pineapples of Solidarity, Katie Dean, Wai Jack Sin, Ian Dundore, Justin, Mark, Caleb Weeks__Want to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashCourseTwitter - http://www.twitter.com/TheCrashCourseInstagram - https://www.instagram.com/thecrashcourse/CC Kids: http://www.youtube.com/crashcoursekids Learn more about your ad choices. Visit megaphone.fm/adchoices
Time for another Bad Astronomy break.Check out the Crash Course Astronomy solar system poster here: http://store.dftba.com/products/crashcourse-astronomy-poster--PBS Digital Studios: http://youtube.com/pbsdigitalstudiosFollow Phil on Twitter: https://twitter.com/badastronomerWant to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashCourseTwitter - http://www.twitter.com/TheCrashCourseTumblr - http://thecrashcourse.tumblr.com Support CrashCourse on Patreon: http://www.patreon.com/crashcourse Learn more about your ad choices. Visit megaphone.fm/adchoices
In which John Green sings the Crash Course intro song, is interrupted by quite possibly the loudest truck in all existence, and attempts to pronounce the most difficult word in the history of words - which is apparently "misanthropy."Crash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourseWant to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashCourseTwitter - http://www.twitter.com/TheCrashCourseInstagram - https://www.instagram.com/thecrashcourse/CC Kids: http://www.youtube.com/crashcoursekids Learn more about your ad choices. Visit megaphone.fm/adchoices