Insulin Resistance and Heart Disease | Dr. Anthony G. Jay - E459

Dr. Eric Berg, D.C., is a chiropractor, bestselling author, and internationally recognized health educator known for his work in ketogenic nutrition, intermittent fasting, and metabolic health. Through his popular YouTube channel and books, including The Healthy Keto Plan, Dr. Berg makes complex health topics accessible, helping millions explore the connections between nutrition, metabolism, and overall wellness. In this episode, Dr. Brian and Dr. Berg talk about… (00:00) Intro

A ketogenic diet can dramatically improve metabolic health while sending LDL-C through the roof. So what's actually happening? Dr. Josh Wageman and Dr. Laura Buchanan break down their new study, "Increased LDL-C reduction with ezetimibe in ketogenic diet-induced hypercholesterolemia." The results raise some fascinating questions. In 14 patients who developed very high LDL-C while following a ketogenic diet, ezetimibe cut median LDL-C from 254 to 127 mg/dL—a remarkable 53% reduction. Why was the response so much greater than what's typically seen with ezetimibe? Could altered cholesterol absorption help explain why some people experience dramatic LDL increases on keto? Josh Wageman, Matt Calkins, and Laura Buchanan take us inside the study, explore the biology behind the findings, discuss what the results can—and cannot—tell us about cardiovascular risk, and explain why much more research is needed. If you've ever wondered why LDL can rise so dramatically on a ketogenic diet—and what might be driving it—this is a conversation you won't want to miss. In this episode, Dr. Tro, Dr. Buchanan, Dr. Calkins, and Dr. Wageman talk about… (00:00) Intro

Dr. Annette Bosworth, known as Dr. Boz, is a physician, educator, and bestselling author who has become a leading voice in metabolic health and therapeutic nutrition. After witnessing firsthand the limitations of conventional approaches to chronic disease, she began exploring the powerful role of nutrition, fasting, and ketosis in improving health. Through her clinical work and popular educational platform, Dr. Boz helps people understand the science behind metabolic health and turn it into practical, sustainable strategies for everyday life. In this episode, Dr. Brian, Dr. Tro, and Dr. Annette talk about… (00:00) Intro (02:42) A little bit about Dr. Annette and an overview of the research she is working on (11:56) Dr. Annette's research on ketogenic patients and Tirzepatide (21:09) GLP1 non-responders (38:01) Sardine fasting (42:25) Food noise and behavioral change (49:35) Outro For more information, please see the links below. Thank you for listening!

Brian Ruby is the founder of Medifoodz, a company focused on making therapeutic ketogenic nutrition more practical, accessible, and sustainable. Through Medifoodz's Glyvance program, Ruby is combining chef-prepared ketogenic meals with continuous glucose monitoring, digital support, and clinician oversight to help patients translate metabolic health science into everyday life. His work centers on one of the biggest challenges in nutrition-based care: not simply knowing what to eat, but making it easier to consistently eat that way. Dr. Adrian Soto-Mota, MD, PhD, FACP is an internist, metabolic researcher, and professor whose work focuses on human metabolism, ketone biology, and evidence-based approaches to metabolic disease. He earned his PhD in Physiology and Metabolism from the University of Oxford and has conducted research on exogenous ketones, glucose metabolism, and cardiovascular health. Zetia Study: https://link.springer.com/article/10.1186/s12944-026-03034-w In this episode, Dr. Brian, Dr. Tro, Dr. Adrian, and Brian Ruby talk about… (00:00) Intro (02:20) Why Brian Ruby founded Medifoodz (09:49) Dr. Soto Mota's recent study pitting the ADA's recommended diet and a ketogenic diet (22:28) The hardest barrier to entry most people struggle to overcome when starting a keto diet (26:15) Why CGMs are so incredibly valuable sustainability (32:16) Babies, dogs, and real food (39:24) Big Food and subsidies (45:58) Real food and dietary motivation (51:38) The AHA recommended diet diabetes reversal (59:15) Accepting and embracing criticism (01:05:51) Dr. Soto Mota's recent Zetia Study (link below) (01:18:24) Outro

Catherine Seo, PhD is the founder of Lipedema Simplified and director of The Lipedema Project. A psychologist, educator, and lipedema advocate, Catherine's work grew from her own experience with lipedema and lymphedema. She produced and directed the documentary The Disease They Call FAT and has dedicated her career to raising awareness, advancing research, and empowering women living with lipedema. Siobhan Huggins is a researcher, metabolic health advocate, and Research Specialist with Lipedema Simplified and The Lipedema Project. Diagnosed with lipedema in 2021, she focuses on ketogenic nutrition, cholesterol metabolism, inflammation, and metabolic health. Siobhan is also a co-founder of Own Your Labs and an international speaker on lipedema and the potential role of low-carb nutrition in managing the condition. In this episode, Dr. Brian, Dr. Tro, Catherine, and Siobhan talk about… (00:00) Intro