The Fasting Mimicking Diet - A Powerful Tool for Treating Cancer - with Valter Longo | EP 200
The Empowering Neurologist PodcastShow Notes
🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 Cancer remains a formidable global challenge, with nearly one in six deaths worldwide attributed to the disease. Over 60% of patients undergoing conventional treatments experience severe side effects, highlighting the need for complementary therapies that enhance efficacy and reduce harm.
Dr. Valter Longo, a leading figure in aging and nutritional science, has introduced a groundbreaking approach known as the fasting mimicking diet (FMD). Through years of research, Dr. Longo has shown that cycles of controlled fasting can trigger cellular regeneration, reduce inflammation, and improve metabolic health.
His work has reshaped our understanding of nutrition’s role in health and disease, providing a scientific basis for fasting as a tool to support standard cancer therapies. The fasting mimicking diet offers a promising adjunct to traditional treatments. By strategically reducing calorie intake, FMD protects healthy cells and makes cancer cells more vulnerable to chemotherapy and radiation.
This dual effect boosts the effectiveness of treatment while mitigating debilitating side effects. Dr. Longo’s new book, Fasting Cancer, the subject of our podcast, explores the science behind fasting and its potential to transform cancer care. He shares practical guidelines, compelling case studies, and robust research that illustrate how FMD can be integrated with standard therapies for better outcomes.
Listeners of The Empowering Neurologist were captivated by Dr. Longo’s ability to translate complex science into actionable advice in his previous appearance, and this episode is no exception. His work continues to inspire both patients and healthcare professionals to explore innovative, science-driven approaches in the fight against cancer.
As research unfolds, the fasting mimicking diet stands as a testament to the power of nutritional science in modern medicine. Embracing this strategy, patients and clinicians alike are witnessing a promising future in cancer care.
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00:00 Introduction 02:10 The Cancer Nutrition Scientist Changing Everything 04:36 How Cancer Cells Hack Aging And Stay Immortal 06:00 The Hidden Danger Of Cancer Cell Survival After Chemo 07:30 Why Young People Are Getting More Cancer Than Ever 10:48 Are We Eating Too Much Protein For Longevity 13:22 A Diet That Weakens Cancer But Shields Healthy Cells 17:55 What Is The Fasting Mimicking Diet And Why It Works 21:40 The Critical Timing That Makes Chemo More Effective 23:00 How Starving Cancer Creates A Predictable Weak Spot 27:30 The Multi-Angle Attack That Slows Glioblastoma 29:15 Could This Diet Delay Or Reverse Alzheimer’s 32:50 Clinical Trials Show This Diet Reverses Diabetes 36:30 How Fasting Triggers Organ Regeneration In Humans 41:05 The Shocking Risks Behind Popular Weight Loss Drugs 57:14 Conclusion
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Valter Longo is the director of the Longevity Institute at the University of Southern California in Los Angeles. He studies basic and clinical research on nutrition, aging, and disease, with a focus on cancer, autoimmunity, Alzheimer’s, and cardiometabolic illness. Dr. Longo has received multiple awards including the 2010 Nathan Shock Lecture Award from the National Institute on Aging, the 2013 Vincent Cristofalo Rising Star Award, and the 2016 Glenn Award for Research in the Biological Mechanisms of Aging. In 2018, Time named him one of the 50 most influential people in health care, and in 2021 Science magazine called him a pioneer in nutrition and cancer. He is the author of Fasting Cancer and The Longevity Diet.
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🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter's newsletter at: https://www.drperlmutter.com Sponsors & Special Offers EVY – Go to https://www.optoceutics.com/perlmutter to get 10% off & free shipping (90 days risk-free). Memory Air – Go to https://www.memoryair.com and use code PERLMUTTER for 15% off, free shipping and a 60-day money back guarantee. Brain Defenders – Dr. Perlmutter's groundbreaking new book is now available! Discover how to protect your brain and future health: https://www.braindefenders.com About This Episode You can be successful, respected, and highly productive while still feeling invisible. In this episode of The Empowering Neurologist, Dr. David Perlmutter sits down with John R. Miles, bestselling author, behavioral change expert, and host of Passion Struck, to explore why achievement, recognition, and external success do not always create a lasting sense of self-worth. Drawing from his childhood brain injury, military service, and executive career, John explains the concept of human mattering: the fundamental need to feel seen, valued, and significant. They discuss the “mattering gap,” the “slow fade” that can happen when people become disconnected from themselves, and why belonging and mattering are not the same. John also introduces the MATTER framework, built around six conditions that help people feel valued and connected: meaning, autonomy, trust, time, energy, and reciprocity. They explore how parents, leaders, physicians, and communities can help others feel that they matter, and why separating personal worth from productivity and external approval can lead to more meaningful relationships and intentional living. You can continue pursuing success without making it the measure of your worth. Your value is not something you have to earn. Timestamps 00:00 – John Miles’ Childhood Brain Injury and Defining Moment 06:16 – What It Means to Matter vs. Belong 07:32 – The Slow Fade: When Success Makes You Feel Invisible 14:43 – Understanding the Mattering Gap 19:34 – Why Children Need to Feel Seen and Valued 27:20 – The MATTER Framework: Six Conditions for Feeling Valued 31:13 – Why Patients Need to Be Seen Beyond Their Diagnosis 36:11 – Creating a Workplace Where Employees Feel Valued 44:31 – Why Your Worth Is Already a Completed Fact 48:32 – The Difference Between Proving Yourself and Accomplishing Goals About John R. Miles John R. Miles is a bestselling author, keynote speaker, behavioral change expert, and host of the award-winning, top-ranked podcast Passion Struck®. A former U.S. Navy officer and Fortune 50 C-suite executive, John combines military discipline, corporate strategy, neuroscience, and psychology to help people and organizations reduce isolation, strengthen self-worth, and live with greater intention. He is the author of Passion Struck and The Mattering Effect. His work explores how people can separate their inherent worth from external achievement, build deeper relationships, and create a meaningful impact without losing themselves in the process. Through his books, podcast, speaking, and global community, John leads a growing movement centered on one essential message: every person deserves to feel seen, valued, and significant. Connect with John Website: https://johnrmiles.com Instagram: https://www.instagram.com/john_r_miles LinkedIn: https://www.linkedin.com/in/johnmileshumanperformanceexpert Facebook: https://www.facebook.com/johnrmiles.c0m Podcast: https://passionstruck.com/passion-struck-podcast Connect with Dr. Perlmutter Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ This podcast is produced by DrTalks.com http://drtalks.com/channel-growth
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🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉ 🌱 Thank you to our sponsors: EVY - https://www.optoceutics.com/perlmutter and the code perlmutter26 will be auto-applied to your order to get 10% off & free shipping (90 days risk-free). 3X4 Genetics - https://3X4genetics.com/DrPerlmutter for a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations. ==== Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available! Discover how to protect your brain and future health - grab your copy today at https:/www.braindefenders.com. ==== Why do some people feel exhausted, mentally foggy, metabolically unwell, or simply older than they should even when their routine laboratory results are considered “normal”? That question is at the heart of this episode of The Empowering Neurologist, featuring functional medicine practitioner Dr. Will Cole, coauthor with Dr. Josh Axe of Heal Your Cells: Reversing the Irreversible. Dr. Cole and Dr. Perlmutter explore the idea that long before disease becomes obvious, dysfunction may already be developing at the cellular level. This concept takes on particular importance when we consider the brain, which accounts for only about 2% of body weight but consumes roughly 20% of the body's energy at rest. The conversation examines how seemingly separate factors including metabolic dysfunction, chronic inflammation, poor sleep, environmental exposures, physical inactivity, and prolonged psychological stress can converge on the same cellular systems and ultimately influence brain health. 00:00 — Why Your Cells May Be Aging Before You Feel It 03:44 — Meet Dr. Will Cole 04:50 — What Is Cellular Dysfunction? 09:25 — Why Healthy People Can Still Develop Disease10:32 — The Environmental Factors Affecting Cellular Health 15:47 — Why Mitochondria Are Central to Health 16:37 — How Mitochondrial Dysfunction Drives Inflammation 19:57 — How Much of Aging Can We Actually Change? 20:47 — The Connection Between Mitochondria and Insulin Resistance 25:43 — Mitochondria, Microglia, and Brain Inflammation 29:28 — Why There Is No One-Size-Fits-All Diet 32:03 — Training Your Cells to Become More Resilient 32:46 — What Are “Adversity Mimetics”? 35:51 — Why Intracellular Health Matters 36:32 — Why Conventional Medicine May Be Missing Cellular Dysfunction 37:58 — What Do We Really Know About Peptides? 40:16 — Is Ozone Therapy Worth Considering? 42:30 — Ozone and the Science of Cellular Resilience 43:41 — What Is Therapeutic Plasma Exchange? 45:38 — Who Might Benefit From Plasma Exchange? 46:45 — The Everyday Habits That Support Cellular Health 51:35 — Your Cells Are Responding to the Choices You Make Dr. Will Cole is a leading functional medicine expert specializing in thyroid health, autoimmune conditions, hormonal imbalances, digestive disorders, and brain health. He is the host of The Art of Being Well podcast and a New York Times bestselling author of Intuitive Fasting, Ketotarian, The Inflammation Spectrum, and Gut Feelings. - - - - - Connect with Dr. Will Cole Website: https://drwillcole.com Instagram: https://www.instagram.com/drwillcole LinkedIn: https://www.linkedin.com/in/drwillcole Facebook: https://www.facebook.com/doctorwillcole Podcast: https://open.spotify.com/show/6z1lJ5dfKNHwGGQPOFTc7E Apple Podcasts: https://podcasts.apple.com/us/podcast/the-art-of-being-well/id1539535133 - - - - - Connect with Dr. David Perlmutter, MD Website: https://www.drperlmutter.com/ Instagram: https://www.instagram.com/davidperlmutter/ Facebook: https://www.facebook.com/DavidPerlmutterMD/ YouTube: https://www.youtube.com/@DavidPerlmutterMD X (Twitter): https://x.com/DavidPerlmutter - - - - - PODCAST Thank you for listening. Please subscribe and share. This podcast is produced by DrTalks.com https://drtalks.com/podcast-service/