Read Your Genes! APOE4, Brain Health, and Longevity | HOMe Podcast #026

In this episode of the Health Optimization Medicine Podcast, Boomer Anderson sits down with Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Scott Sherr for a different kind of conversation focused on mental health, presence, and the Six Nails of Tilopa. Dr. Achacoso introduces the Six Nails of Tilopa through the mnemonic RITEC R: don't recall, don't imagine, don't think, don't examine, don't control, and relax into effortless awareness. The discussion explores how these principles can be applied to everyday life, particularly when dealing with grudges, future-oriented anxiety, overthinking, perfectionism, and the desire to control outcomes. Join us as we delve into: What Safety Feels Like: How breathing, muscle tension, posture, guarding, and a sense of choice may provide information about how a person is experiencing safety.

In this episode of the Health Optimization Medicine Podcast, Dr. Allen Bookatz and Jodi Duval explore safety as a biological state and examine what happens when a threat has ended but the body's response has not yet fully resolved. The conversation looks at safety from two interconnected perspectives: the cell and the nervous system. Jodi explains how cells respond to threats through the Cell Danger Response, while Allen explores how the nervous system continuously evaluates the body's internal and external environment and determines how much of the system should remain committed to protection. A central theme throughout the episode focuses on the idea that the end of an acute threat is not necessarily the end of the healing response. The discussion explores what happens when the body remains organized around protection, even after the original crisis has passed. Join us as we delve into: Safety as a Biological State: Why safety is more than simply removing an immediate threat and why the body may require additional signals before returning to normal function.

In this special episode of the Health Optimization Medicine Podcast, Dr. Jup Kuipers, Dr. Ted Achacoso, Dr. Allen Bookatz, and Dr. Scott Sherr discuss how toxicities can build up over time, affect cellular energy production, and eventually show up as problems across different organ systems. The team looks at two clinical cases involving mercury and arsenic exposure, and how symptoms were initially treated as separate problems by different specialists. They discuss why chronic, lower-level exposure can be difficult to identify, how heavy metals can interfere with mitochondrial function, and why looking at the cell may reveal a different picture than looking only at the organ that is showing symptoms. Join us as we delve into: The Limits of Organ-Based Medicine: Why specialists may correctly identify the affected organ while missing the shared environmental or metabolic cause.

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr sits down with Dr. Bryce Appelbaum to discuss the connection between vision, screen time, brain function, and nervous system regulation. Most people think of vision as eyesight, or how clearly they can see an eye chart. Dr. Appelbaum explains why vision is much broader. It involves how the brain receives information through the eyes, interprets the environment, coordinates movement, and decides how to respond. The conversation explores how prolonged screen use can narrow peripheral awareness, increase visual stress, and keep the nervous system in a more activated state. They also discuss the rise of myopia, the difference between eyesight and functional vision, and how vision performance training may support reading, learning, reaction time, spatial awareness, athletic performance, and recovery after concussion or traumatic brain injury. Join us as we delve into: Screen Time and the Nervous System: How prolonged engagement with close, two-dimensional screens can contribute to visual stress, tunnel vision, fatigue, and sympathetic activation.

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Allen Bookatz, and Jodi Duval explore the glymphatic system and the role sleep plays in clearing metabolic waste from the brain. Getting eight hours of sleep does not necessarily mean getting eight hours of effective brain clearance. The team looks at how the autonomic nervous system, norepinephrine, cerebrospinal fluid and interstitial fluid exchange, aquaporin-4 channels, circadian timing, body temperature, gut barrier integrity, and even anxiety around wearable sleep scores may influence the conditions needed for healthy glymphatic flow. The discussion also introduces a practical HOMeHOPe glymphatic optimization protocol focused on creating the chronobiological, bioenergetic, and environmental conditions that support natural overnight brain clearance. Join us as we delve into: How the Glymphatic System Works: How cerebrospinal fluid moves through perivascular spaces, exchanges with interstitial fluid, and helps remove metabolic waste including beta-amyloid, tau, and cellular metabolites.