Mind & Life

Dave Vago – Meditation, Neuroscience, and Self

Mind & Life

Show Notes

In this episode, Wendy speaks with contemplative neuroscientist Dave Vago. Dave has been studying the brain, meditation, and the self for over two decades, and has developed several models of how mindfulness might work from cognitive and neurobiological perspectives. This conversation covers many topics, including:

his intertwined interests in brain, mind, self, philosophy, and religion;

the temporal nature of memory;

mindfulness for fibromyalgia and chronic pain;

unconscious attentional bias;

sticky thoughts and how they change with meditation;

the role of the self in contemplative practice (S-ART model);

meta-awareness and decentering;

the centrality of inhibitory control in contemplative practice;

dissolving the self/other divide;

integrating wisdom to create meaning;

how meditation can shift attentional bias at very early levels of processing;

the deeply interconnected nature of brain function;

self-pattern theory and (in)flexibility in the mind;

mindfulness and the glymphatic system, and implications for sleep and neurodegenerative disorders;

and the new academic society for contemplative research (ISCR). Full show notes and resources

More from Mind & Life

Jul 10, 2026

To conclude this mini-series, guest host Jamie Bristow is joined by Gretchen Steidle, cathy-mae karelse and Rufus Pollock to step back from individual approaches explored so far and consider the wider field they are collectively helping to shape. As interest in contemplative approaches to social and ecological transformation continues to grow, how do we make sense of a rapidly expanding landscape of people, projects, organisations and ideas? Together, they discuss the importance of mapping emerging fields: not simply to catalogue what exists, but to help practitioners find one another, foster collaboration, identify gaps, and make the field more visible to researchers, funders and institutions. The conversation also explores what it takes for an emerging movement to develop coherence, legitimacy and shared purpose. Bringing the series to a close, it offers a hopeful bird's-eye view of a field that is beginning to recognise itself, and asks what might be needed for its next stage of maturity. cathy-mae karelse, PhD, a changemaker and scholar practitioner who leads Climate Youth Resilience, a global south-facing program that approaches climate resilience and systems change from the inside out. Rufus Pollock, who is co-founder of Life Itself and the Second Renaissance Initiatives and is focused on inner-led social change to renew our civilization's foundations. Gretchen Steidle, Director of Spirituality and Social Change at the Garrison Institute and Chief Weaver for the Conscious Change Collective, a network of practitioners Full show notes and resources

Jun 26, 2026

In this episode of the mini-series on systems change, guest host Jamie Bristow turns the lens around. Rather than beginning with a particular inner approach and asking what it might offer, the conversation starts with the system itself: the patterns, power dynamics and meaning-making structures that shape the crises we face. Joined by Rachel Lilley, Thomas Legrand, and Wakanyi Macharia-Hoffman, Jamie explores why contemplative and embodied approaches may be vital not only for shifting deep leverage points such as worldview and values, but also for helping systems practitioners navigate complexity, bias, and uncertainty. From food systems and public policy to AI, Ubuntu, and embodied systems leadership, the discussion ranges widely while staying grounded in a central question: what does it take to work with systems in ways that are more relational, reflective, and transformative? The result is a rich conversation about inner-led change, viewed through a broader systems lens. Thomas Legrand is Lead Advisor for the UNDP-convened Conscious Food Systems Alliance, and the author of Politics of Being: wisdom and science for a new development paradigm. Rachel Lilley is an Associate Professor at the University of Birmingham, where she is programme director of the MSc in Systems Thinking and Leadership and pioneers the integration of embodied practice and inner inquiry into systems practice. Wakanyi Macharia-Hoffman is an Ubuntu philosophy thinker, the founder of African Folktales Project and the director of African AI Design Research at Inclusive AI Lab, Utrecht University. , where she bridges indigenous African knowledge for inner human development with AI design ethics.

Jun 5, 2026

Jon Kabat-Zinn didn't invent MBSR as a stress reduction programme. He created it as a way of meeting suffering—individual, collective, planetary—with greater clarity and care. Somewhere in the journey to the mainstream, that wider vision narrowed in the public conception. This episode is, in part, a return to the source. Guest host Jamie Bristow is joined by Jon Kabat-Zinn, Paula Ramírez Díazgranados and Liane Stephan to explore what mindfulness becomes when it is brought back into relationship with the world: with trauma and conflict, with institutions and food systems, with the tragedy of ecological crisis. Their conversation moves through medicine, humanitarian response and sustainability work, but the deeper thread running through all of it is relational: the question of what contemplative practice can offer when the patient is not only the individual, but the communities and systems we are part of.

May 22, 2026

In this panel conversation, guest host Jamie Bristow is joined by Katrin Kaufer, Martin Kalungu-Banda and Megan Seneque to explore Theory U and the wider field of awareness-based systems change. Developed through the Presencing Institute, Theory U is one of the most widely applied approaches to systems change that explicitly integrates contemplative practice with collective transformation. Together, they examine how this work helps people move beyond habitual responses, deepen the quality of attention and relationship, and create the conditions for new futures to emerge. The conversation ranges from leadership and social innovation to public health, higher education, research, and global systems work, while also asking harder questions about evidence, integrity, access, and scale. The result is a rich and searching exploration of what it means to work with complexity in ways that are rigorous, relational, and open to emergence.

May 8, 2026

In the second panel conversation of this mini-series, guest host Jamie Bristow is joined by Laura Calderón de la Barca, Kazu Haga and Thomas Hübl to explore the rising significance of trauma healing for systems change. As trauma moves from the margins to the mainstream, the conversation asks what we are really naming when we speak of trauma, and how unprocessed experience shapes not only individual lives, but relationships, communities and whole societies. Together, they reflect on the growing recognition that healing need not be a solitary pursuit, and that collective, systemic and intergenerational approaches may be vital in an age of compounding crises. The result is a thoughtful and far-reaching conversation about whether our capacity to relate wisely to trauma may help determine how we meet the pressures of a rapidly changing and imperiled world.

See all episodes →