Razib Khan's Unsupervised Learning

Jason Scharf: Austin's present and future as Texas' tech hub

Razib Khan's Unsupervised Learning

Show Notes

Today Razib talks to Jason Scharf, a biotech investor and podcaster. A native of San Diego, Scharf is an angel investor and startup advisor focused on the intersection of biology, technology, and business, particularly within TechBio and digital health. He has leadership experience in strategy and market intelligence at major companies like Illumina and Amgen. Scharf now targets investments in the bio-innovation tech stack and care delivery transformation. Additionally, as the host of the Austin Next podcast, he is an advocate for regional innovation ecosystems. Scharf promotes the growth of the Texas Triangle as a premier global hub for biotechnology and frontier tech. Razib and Scharf discuss the growth and appeal of Austin, Texas, highlighting its booming tech scene and business environment. Scharf discusses why he moved from San Diego during the COVID-19 pandemic. They compare Austin's population growth to other major cities, noting Austin's rapid expansion from 400,000 in 1990 to over a million in 2020. They also talk about the impact of autonomous vehicles, the potential for high-speed rail, and the importance of infrastructure and talent in sustaining Austin's future growth. The conversation touches on the broader Texas Triangle and its economic significance to the American economy today and in the future. They highlight the libertarian and business-friendly environment in Texas, allowing for significant developments like Tesla's Gigafactory (the world's second-largest building), and the planned Terfab. Razib compares Austin and San Antonio, noting the former's rapid growth and the challenges it faces, such as infrastructure and housing. They also touch on the cultural and economic dynamics in Texas, emphasizing the importance of storytelling and narrative in shaping the state's future.

More from Razib Khan's Unsupervised Learning

Oct 23, 2026

Philippe Lemoine is a researcher and writer specializing in the philosophy of science, statistical analysis, and epidemiology. He is a PhD candidate in philosophy at Cornell University. Previously, he was a Research Fellow at the Center for the Study of Partisanship and Ideology (CSPI). Lemoine is best known for his detailed, data-driven critiques of COVID-19 epidemiological modeling, lockdown policies, and Western foreign policy, which he primarily publishes on his blog, Nec Pluribus Impar (he now has a Substack). In addition to his independent research, he has contributed analytical essays on science and society to publications like Quillette. Razib and Lemoine discuss France's unrest, demographic change, and political paralysis, with Lemoine arguing that the school riots reflect a volatile mix of teenage behavior, social-media contagion, immigrant integration problems, and far-left agitation rather than a centrally organized conspiracy. They examine how viral footage exaggerates outsiders' perceptions of France's ethnic transformation, overlooking regional differences and widespread intermarriage. Turning to presidential politics, Lemoine argues that Marine Le Pen's prospects depend heavily on whether she faces Jean-Luc Mélenchon or the more competitive centrist Édouard Philippe. Beneath these immediate conflicts lies a deeper fiscal problem: weak growth, mounting debt, and generous pension commitments to an aging electorate make reform increasingly necessary but politically punishing. Lemoine anticipates that inflation and financial repression may prove more politically feasible than explicit spending cuts, while Razib emphasizes that the same tensions between retirees and workers increasingly confront the United States and other developed countries.

Oct 22, 2026

Today, Ramez Naam returns 5 years after his original appearance on the podcast. In 2003, he wrote More Than Human: Embracing the Promise of Biological Enhancement. Naam is also the author of three science fiction books: Crux, Apex, and Nexus. In addition, has also written The Infinite Resource: The Power of Ideas on a Finite Planet. He also has an eponymous Substack, Ramez Naam. First, Razib and Naam discuss how technological change is turning once-futuristic possibilities into everyday realities, beginning with the falling costs of solar power, batteries, and electric vehicles. Naam argues that economics increasingly drives adoption, with Texas illustrating how competitive markets and easy permitting can accelerate clean energy even in a fossil-fuel stronghold. Razib probes the implications for transportation, oil demand, and the Gulf states, while Naam emphasizes that the transition will take decades and that heavy industry remains difficult to decarbonize. The conversation then shifts to AI, where Razib presses Naam on existential risk, industry concentration, and recursive self-improvement. Naam expects increasingly powerful systems but doubts an imminent intelligence explosion, pointing to diminishing returns, hardware constraints, and the difficulty of obtaining reliable real-world data. He sees concentrated corporate or government power as a greater threat than runaway superintelligence and favors broad access and competition.

Oct 19, 2026

Today Razib talks to Jerry Z. Muller, a historian and professor emeritus of history at the Catholic University of America in Washington, D.C., specializing in modern European intellectual history, capitalism, conservatism, and German and Jewish history. His work explores how ideas shape economic, political, and cultural life, bridging history, philosophy, and public policy. His books include Conservatism: An Anthology of Social and Political Thought From David Hume to the Present, The Mind and the Market: Capitalism in Modern European Thought, Capitalism and the Jews, The Tyranny of Metrics, and Professor of Apocalypse: The Many Lives of Jacob Taubes. Writing for both scholarly and general audiences, Muller examines subjects ranging from the moral arguments surrounding capitalism to the consequences of relying excessively on numerical measures to evaluate institutions and individuals. He has an eponymous Substack. The conversation revolves to a great extent on a recent post by Muller, Rethinking Faculty Control Scholarly Norms, the Vanderbilt Report, and the Limits of Academic Self-Government. Razib and Muller discuss the challenges facing universities, the resilience of American capitalism, and the effects of AI on intellectual life. Muller argues that scholarship depends on "organized skepticism," including peer review, replication, and engagement with different viewpoints, but that activism and ideological conformity weaken these practices in parts of academia and undermine public trust. They also tackle whether stronger university leadership can help address these problems while managing declining literacy and numeracy, shifting demographics, uncertain international enrollment, rising costs, and pressure to demonstrate results. Muller suggests that vocational training may increasingly separate from liberal arts education and research, raising questions about how universities can adapt while maintaining academic standards and intellectual diversity. He remains broadly optimistic about American capitalism, pointing to technological innovation, competition among states, immigration, and social supports. Both view AI as a powerful tool for skilled thinkers but a potential source of intellectual passivity for others, raising the question of how people can preserve their agency and sense of purpose as AI becomes part of everyday intellectual work.

Oct 15, 2026

Today Razib talks to Theo Jaffee, co-host of Monitoring the Situation, a show backed by Andreessen Horowitz that covers the rise of the "intelligence explosion" and AI. Jaffee is writer and podcaster who grew up in Boca Raton, Florida. He studied computer science and economics at the University of Florida. His writing on Theo's Substack explores artificial intelligence, technology, business, history, and philosophy. He has also contributed to Quillette and received an Emergent Ventures fellowship in 2024. The podcast covers AI's accelerating capabilities, broader societal impact, and safety risks. Jaffee talks about estimates of a 10% probability of human technological civilization collapsing within ten years, distinguishing between the disempowerment of humanity and the potential continuation of civilization under AI control. But, he notes, coordination, political intervention, and the logistical difficulty of automating physical infrastructure can mitigate that catastrophic risk. Progress remains broadly on track with AI 2027 expectations, despite there being no predicted labor disruptions and Chinese consolidation failing to materialize as forecast. Jaffee notes events like the Hugging Face incident and an apparent Millennium Prize problem solution heighten concerns surrounding alignment and control. Razib and Jaffee also discuss how critical uncertainties persist over how rapidly recursive self-improvement might yield superintelligence, whether mounting political backlash will establish viable safeguards or trigger heavy-handed stagnation, and how society must ultimately evaluate AI consciousness and moral status.

Oct 11, 2026

Today Razib talks to Scott Greer, an American conservative writer, author, and podcaster who focuses on nationalism, immigration, online political culture, and the transformation of the Republican Party. Formerly an editor and columnist at The Daily Caller, he now hosts the Highly Respected podcast and newsletter and contributes to The American Conservative. He is the author of No Campus for White Men (2017) and Whitepill: The Online Right and the Making of Trump's America (2026), a history of how paleoconservatism, libertarianism, the alt-right, and other internet subcultures helped shape Trump-era politics. The first half of the conversation focuses on Whitepill, as Greer outlines a narrative history of the rise of the New Right and its relationship to MAGA and Donald Trump over the last decade. The conversation goes back even further, to the origins of the dissident Right in the Ron Paul movement of the late aughts. Then they move to discussing a piece recently posted on Highly Respected, Sunbeltism Takes Over America–And The South. A native of Tennessee, Greer talks about the implicit conservatism of the ascendant Sunbelt culture, but its broader cultural and social influence, and its difference from earlier Southern subcultures fixated on the "Lost Cause" and rooted in an agrarian society.

See all episodes →