Peptide Show

Dylan Gemelli: Can you trust the peptides you’re buying?

Peptide Show

Show Notes

What happens when the people profiting from peptides have different motives from the people relying on them?

For the past 15 years, the fitness and biohacking educator and host of The Dylan Gemelli Podcast has watched peptides move from bodybuilding forums and research chemical sites into the mainstream. Then the market changed around him. GLP-1s propelled peptides into public consciousness. BPC-157 became one of the compounds most closely associated with the category. And an underground market expanded alongside them, where suppliers, testing and certificates of analysis can create an appearance of certainty that may not always be justified. Gemelli believes peptides have far more potential than the handful of compounds dominating the conversation. But he is equally concerned by what happens when consumers buy from unregulated suppliers, assume a COA proves quality, or trust that what is on the label is what is actually in the vial. He explains:

■ How peptides went from obscure research chemicals to the mainstream ■ Why GLP-1s and BPC-157 have narrowed the public understanding of peptides ■ Why a certificate of analysis does not necessarily prove what is actually in the vial ■ What consumers should understand about underground suppliers, raw materials and peptide testing ■ Why he believes peptides will become more widely accepted, and why he worries about who ultimately controls them Chapters

(00:00) - Intro

(02:09) - Fifteen years in peptides

(09:17) - How peptides went mainstream

(13:35) - The GLP-1 and BPC-157 problem

(16:47) - Peptides beyond GLP-1s

(19:18) - Protecting muscle on GLP-1s

(22:11) - Are GLP-1s overprescribed?

(23:12) - Inside the underground peptide market

(23:56) - Where peptide raw materials come from

(25:07) - Why COAs can mislead you

(26:04) - Suppliers, Reddit and white-labelling

(29:24) - Who controls the future of peptides?

Watch the full episode on YouTube

Further reading

FDA: Concerns around unapproved GLP-1 drugs, foreign APIs, illegal online sales and products marketed as being for research purposes: FDA: Concerns with unapproved GLP-1 drugs FDA: July 2026 Pharmacy Compounding Advisory Committee meeting covering BPC-157, KPV, TB-500, MOTS-c and other peptide-related bulk substances: FDA PCAC July 2026 meeting Read the full transcript

Follow Dylan Gemelli

Instagram: Instagram.com/dylangemelli X: x.com/DylanGemelli YouTube: YouTube.com/@DylanGemelliBiohacking Website: DylanGemelli.com

Follow Richard Skaife

LinkedIn: https://www.linkedin.com/in/richardskaife/

Peptide Show

Website: Peptide.Show

The Peptide Show explores the science, medicine, business and people shaping the rapidly evolving world of peptides. Presented by Longr: longr.io

Follow The Peptide Show for new episodes every Tuesday. This podcast is for informational and educational purposes only and does not constitute medical advice. Some compounds discussed in this episode are investigational, unapproved for the uses discussed, or subject to changing regulatory requirements.

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