773: What’s Really Driving How Fast You Age? The Science of Biological Aging with Nikolina Lauc

What if perimenopause isn’t only changing your hormones, but also changing how your body is aging underneath the surface?

In this episode, Dr. Mariza sits down with Nikolina Lauc, CEO and co-founder of GlycanAge, to explore emerging research on immune aging, chronic low-grade inflammation, and the menopause transition.

Nikolina shares research showing just how dramatically markers of “inflammaging” can shift when estrogen declines. In one hormone-blocking study, women gained 9.1 years on GlycanAge markers within six months, while research following twins found the rate of immune aging accelerated during the transition from perimenopause to menopause.

They unpack why this inflammation may be happening even when your traditional labs look normal, what glycans can reveal about how your immune system is functioning, and why biological age is more complex than a single number.

They also explore the research around HRT, exercise, weight loss, fasting, GLP-1 medications, nutrition, and why the same intervention doesn’t work the same way for every woman.

Listen now to discover what may be happening beneath the surface in perimenopause and how better data could help you become more proactive about how you age.

NIKOLINA LAUC

Nikolina Lauc is the CEO and co-founder of GlycanAge, a longevity biotechnology company focused on glycans, immune aging, chronic inflammation, and biological age.

GlycanAge’s research focuses specifically on “inflammaging,” the chronic, low-grade systemic inflammation associated with aging. Its work examines glycan structures on antibodies to better understand whether the immune system is behaving in a more pro-inflammatory or anti-inflammatory way.

IN THIS EPISODE

What biological age actually means and why there isn’t one universal biological-age number

How chronic low-grade inflammation can develop without obvious symptoms

Why immune-aging markers may accelerate during the menopause transition

How declining estrogen influences inflammation and immune function

Why your hormone and traditional inflammatory labs can look normal while something is shifting

What glycans can reveal about your immune system and inflammaging

What the research suggests about HRT, exercise, weight loss, fasting, and GLP-1s

Why interventions for healthy aging need to be personalized

QUOTES

“There’s never going to be one biological age.”

“Not everybody experiences perimenopause in the same way.”

“There’s no universal diet.”

RESOURCES MENTIONED

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GlycanAge LinkedIn

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