Periodic Labs: A chatbot walks into a laboratory

Pete Florence and I began by agreeing that his company has an excellent name. Generalist builds AI for robots, including models that can begin learning a new task from a single demonstration. We talked about dexterity, the strange business of gathering physical experience for a machine, and what we might build if robots could do much more of the work. — Every timestamp 00:00 Intro 02:24 GEN-1.5 and one-shot learning 08:55 What makes a task difficult 10:53 Dexterity in robotics 14:53 Matt Mason’s definition of a hand 17:34 Giving robots a sense of touch 20:30 Growing up in a family of technologists and scientists 22:46 What drew Pete into robotics 27:38 Generalist’s founding thesis and what sets it apart 32:17 Protecting simplicity 35:01 How Generalist’s data collection has evolved 35:30 Generalist’s scaling philosophy 39:53 Generalist’s build-versus-buy philosophy 42:15 Balancing general intelligence with commercial deployment 44:24 Why Pete is betting on dexterity 47:33 The durability of the robotics application layer 49:09 Open-weight robotics models and data flywheels 50:52 Geopolitics, safety, and alignment 52:42 The parallels between teaching humans and robots 1:00:05 The timeline for robotics progress and adoption 1:03:37 Book recommendations — Transcript: https://www.generalist.com/i/220756708/transcript — Pete’s complete reading list The Score Takes Care of Itself: My Philosophy of Leadership: https://www.amazon.com/Score-Takes-Care-Itself-Philosophy/dp/1591843472 Wooden on Leadership: How to Create a Winning Organization: https://www.amazon.com/Wooden-Leadership-Create-Winning-Organization/dp/0071453393 — Other resources Generalist: https://generalistai.com GEN-1.5: https://generalistai.com/blog/gen-1.5 Proprioception: https://en.wikipedia.org/wiki/Proprioception Cutaneous receptor: https://en.wikipedia.org/wiki/Cutaneous_receptor Fukushima nuclear accident: https://en.wikipedia.org/wiki/Fukushima_nuclear_accident The bitter lesson: https://www.cs.utexas.edu/~eunsol/courses/data/bitter_lesson.pdf GEN-1: https://generalistai.com/blog/gen-1 — Where to find Pete Florence LinkedIn: https://www.linkedin.com/in/peteflorence X: https://x.com/peteflorence Website: https://www.peteflorence.com — Production and marketing by penname.co. For inquiries about sponsoring the podcast, email [email protected].

Jaan Tallinn is a founding engineer of Skype and Kazaa, and a co-founder of the Cambridge Centre for the Study of Existential Risk and Future of Life Institute. For more than fifteen years, he has been among the most consistent voices arguing that advanced AI poses an extinction-level risk to humanity.

Scott Morton is the founder and CEO of Revel, a software platform for testing and controlling complex hardware systems. Before founding the company in 2024, Scott spent nearly a decade at SpaceX building control software for Falcon 9 and Starship. That experience helped him recognize a broader problem: while rockets, nuclear systems, supersonic aircraft, and other advanced machines have grown increasingly sophisticated, the software used to test and control them is often fragmented and decades old. Revel was created to close that gap. The company has raised $180 million, was reportedly valued at just over $1 billion, and counts Impulse Space and Radiant Nuclear among its customers. Its platform scales from small benchtop tests to industrial systems with hundreds of thousands of telemetry channels. Revel has also created its own programming language, RevelCode, designed to combine performance and accessibility with the runtime safety required for high-stakes physical systems.

Farooq Malik is the co-founder and CEO of Rain, a financial infrastructure company powered by stablecoins. Growing up in an immigrant family, Farooq saw firsthand the friction involved in moving money across borders. Alongside co-founder Charles Yoo-Naut, Farooq spent years building infrastructure before stablecoins became mainstream, betting that tokenized money would eventually become a foundational layer of the global financial system. Today, Rain powers card issuance, payments, and other financial products built on stablecoin rails, helping companies move money faster and operate across markets.

Eric Nguyen is the co-founder and CEO of Radical Numerics, an AI research lab that has raised $50 million to train models directly on biological data. Before starting the company, Eric helped develop Evo and Evo 2, large-scale genome language models trained on unlabeled DNA sequences. Radical Numerics is now building models that can connect information across DNA, RNA, proteins, epigenetics, and other parts of biology, rather than treating each as a separate problem. Researchers have already used Evo to generate viable bacteriophage genomes, and Eric says Radical Numerics’ newer model, Omnii, matched key findings from two years of Alzheimer’s wet-lab research in a matter of days. He also believes these tools could make it easier to create dangerous pathogens, which is why the company is working on both biological design and biodefense.