#90: This Brain Aging Study Is Our New Favorite!

Neuroscientist Dr. Sarah McKay has spent more than a decade tracking what the science actually says about women's brains, from pregnancy through menopause. She's the author of The Women's Brain Book, Baby Brain, and Brain Health For Dummies. We talk about why the grey matter changes of pregnancy look like a reorganization that prepares a mother to care for her baby, why so many women report "baby brain" when lab tests pick up very little, what menopause hormone therapy has and hasn't been shown to do for the brain, and how to talk honestly about uncertainty when social media rewards confident claims.

Your brain runs on roughly 400 miles of blood vessels, and most of them are too small to see on a standard scan. Vascular neurologist Dr. Jason Hinman of UCLA studies how those tiny vessels keep the brain's white matter healthy, and why vascular injury shows up alongside Alzheimer's disease in at least half of patients.

To grab your copy of the book, head to GeniusAndImpostor.com.

Henry Mahncke is the CEO of Posit Science and the creator of BrainHQ, the most researched brain training platform in the world. A neuroscientist who did his PhD with Michael Merzenich, considered the father of adult brain plasticity, Henry has spent two decades translating brain plasticity science into tools that actually improve brain health. In this conversation, we dig into why most brain training criticism misses the point, what the largest clinical trials really show, and why the future of brain health looks a lot like the evolution of physical fitness. In this episode: 00:00 — Introduction and Henry's background (PhD with Merzenich at UCSF, McKinsey, founding Posit Science) 07:00 — Brain training vs. cognitive training: why the distinction matters 09:00 — Brain plasticity as the driver of brain health, and why cognitive reserve is really just brain health 13:00 — Maladaptive brain plasticity: how aging actively degrades information processing through negative plasticity 18:00 — How BrainHQ exercises are designed: adaptive speed and accuracy training from psychophysics 24:00 — The transfer and generalization debate: does brain training improve real-world function? 28:00 — Clinical trial evidence: the Mayo/USC RCT, the ACTIVE study, and 300+ published papers 34:00 — The pharmaceutical analogy: why asking "does brain training work?" is the wrong question 37:00 — Who is brain training for? From post-concussive disorder to Tom Brady 44:00 — Brain training as physical exercise: the case for everyone at every age 46:00 — Real-world brain plasticity activities: racquet sports, musical instruments, foreign languages 51:00 — Josh's Brainjo origin story and what music training does for the brain 55:00 — The loss of skill learning in modern life and education 58:00 — The "dark ages" of brain health and where the field is headed To submit a question for us to answer on the podcast, go to brainjo.academy/question.

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