Show Notes
Multi cancer detection tests or MCDs can detect many cancers through a simple blood test. Many detect fragments of cancerous DNA that have broken off a tumour and are circulating in the blood. They can often then identify where the cancer may be.
The NHS is currently involved in the words largest trial of one such test. The Galleri test is made by US firm Grail and the company says its mission is to detect cancer early when it can be cured. Heavyweight investors include Jeff Bezos and Bill Gates. More than 140,000 volunteers took part in the trial and the results will be known next year. If successful, the test may be rolled out further. File on 4 Investigates looks at how effective such tests are and whether the trial will show it can save lives. Medical journalist Deb Cohen speaks to one woman whose cancer was found by the test and successfully treated. But she also hears from firefighters in America - where it's available to the public - who say it missed some cancers and some people who got a positive result were found not to have the disease after undergoing diagnostic procedures - a so called false positive. With many hospitals trusts missing cancer treatment targets, what is the best way forward for the NHS to improve outcomes. Reporter: Deb Cohen Producer: Paul Grant Technical producer: Craig Boardman Production co-ordinator: Tim Fernley Editor: Tara McDermott
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File on 4 Investigates reveals the global criminal networks flooding the UK with fake cigarettes. We trace the supply chain smuggling the counterfeits across borders and lay bare the human cost as vulnerable people are moved across continents and made to work and live in clandestine factories here in the UK. We reveal how a secret factory capable of making up to a quarter of a billion cigarettes a year was recently uncovered in the UK and join Belgian customs as they raid a factory making cigarettes bound for the British market. A former senior official in Europol tells us criminal gangs are now making as much money from fake cigarettes as drugs. Presenter: Jane Deith Producer: Paul Grant Production Management: Tim Fernley & Tom Dunster Technical Producer: Richard Hannaford Editor: Tara McDermott
The number of children taken into care before they reach their first birthday is at a worryingly and persistently high level, according to new figures. In many of those cases it is unsafe for parents to look after their children - but experts believe that a significant number of those babies might not have gone into care, if the right support was in place. This programme investigates the support birth families receive and how much of a voice they are given once care proceedings begin. Figures suggest that most children who go on to be adopted are taken into care as babies. Ninety percent of adoptions happen without the written consent of birth parents. It’s led to some using the term ‘modern day forced adoption’ and to calls for a debate about the system. File on 4 Investigates hears about one project in Salford which has been praised for the support it gives to birth families, cutting the number of children going into care and being adopted. In response to our findings Adoption England say that the process provides "children with a permanent, stable and loving family" adding that "Without adoption, the vast majority of these children will remain in care throughout their childhood and, as extensive research shows" they experience "significantly worse outcomes". The government says it is putting £2.4bn into “transforming the children’s social care system” in England and say they want to increase support for children to stay with their family wherever possible. Presenter: Judith Moritz Senior Producers: Claire Kendall & Ashley Kennedy Production Co-ordinators: Tim Fernley & Tom Dunster Technical Producer: Nicky Edwards Editor: Tara McDermott For details of organisations which offer advice and information with adoption and fostering, go online to bbc.co.uk/actionline. Image: Jean and Tye, who is now an adult, are back in contact.
"Tinderbox"conditions created by a long, hot, dry summer brought a record number of wildfires in 2026. Dozens of homes were destroyed or damaged, huge areas of land burned, and one man died. But experts are warning there may be worse to come in future as climate change makes conditions for wildfires in the UK even more likely. The Government banned disposable barbecues in the summer, sent out a wildfire alert to people's mobile phones, and is now planning to hold a wildfire summit. File on 4 Investigates looks at whether the country is prepared for the growing threat, and if the emergency services have the resources to cope. Presenter: Adrian Goldberg Producer: Fergus Hewison Production Co-ordinators: Tim Fernley & Tom Dunster Technical Producer: Richard Hannaford Editor: Tara McDermott
The Ahmadi Religion of Peace and Light moved into a former orphanage in Crewe in 2021. It’s American-born leader Abdullah Hashem has declared himself the Madhi or saviour. But earlier this year, 500 police officers raided the organisation's headquarters, leading to protests in the town throughout the summer. File on 4 Investigates follows the group’s journey from Egypt through Europe to discover what brought them to the UK. Presented by Hayley Mortimer & Emir Nader. Archive: The Ahmadi Religion of Peace and Light / AROPL Studios.
In October 2015 President Xi Jinping was welcomed to Britain on a state visit, the event was seen as the pinnacle of the so called 'Golden Era' of warm relations between the UK and China. Over a decade later, and despite a cooling of that relationship, File on 4 Investigates discovers Chinese state money and influence reaching far into UK companies and universities as China targets British chip and blockchain technology, and asks whether enough is being done to mitigate the threat to national security. Presenter: Paul Kenyon Producer: Anna Meisel Research: Sze-Fung Lee, independent analyst Additional research: BBC Verify Junior Production Manager: Tom Dunster Production Management Assistant: Tim Fernley Technical Producer: Cameron Ward Editor: Tara McDermott