
Show Notes
Brain inflammation may influence behavior, sensory processing, sleep, mood, and cognition in ways many families never realize. In this episode of The Dr. Brighten Show, Dr. Jolene Brighten and Dr. Pejman Katiraei explore the connections between the immune system, gut health, environmental exposures, ADHD, autism, PANS/PANDAS, and neuroinflammation; view the complete show notes at https://drbrighten.com/podcasts/brain-inflammation-and-behavior/
Neurodivergence Is Not the Problem
This episode does not suggest that autism or ADHD should be erased, “fixed,” or reduced to inflammation.
Instead, the conversation explores an important distinction:
A person’s neurodivergent wiring may be an intrinsic part of who they are.
Pain, severe anxiety, sleep disruption, gut dysfunction, overwhelming sensory sensitivity, aggression, or sudden regression may represent additional challenges affecting that person’s quality of life.
Understanding that distinction can help families support the whole person without treating their identity as a disease.
Signs That May Deserve a Closer Look
These symptoms do not confirm a diagnosis, but clusters of symptoms may warrant a more comprehensive conversation with a qualified healthcare professional:
Sudden or dramatic changes in behavior
New fears, phobias, compulsions, or repetitive thoughts
Severe sensory sensitivity to sound, touch, clothing, food, or water
Chronic constipation, diarrhea, abdominal pain, reflux, or bloating
Eczema or recurring skin symptoms alongside digestive concerns
Restrictive eating that appears driven by texture, smell, or sensory distress
Significant sleep disruption or waking consistently during the night
Repeated ear infections, respiratory infections, or unexplained inflammatory symptoms
Symptoms that worsen after illness, certain foods, antibiotics, or environmental exposures
A child expressing beliefs such as “I’m bad,” “I’m mean,” or “I’m stupid” after struggling to control their behavior
Always work with an appropriately licensed healthcare professional before beginning medications, antifungals, restrictive diets, parasite protocols, or treatment for suspected mold-related illness.
👨⚕️ About Dr. Pejman Katiraei
Dr. Pejman Katiraei works with children and families experiencing complex combinations of behavioral, neurological, immune, gastrointestinal, and environmental health concerns. In this episode, he shares clinical observations from his work with children experiencing neuroinflammation, sensory challenges, PANS/PANDAS, gut dysfunction, and significant behavioral changes.
Dr. Pejman Katiraei’s Website: https://drkatiraei.com/
Dr. Pejman Katiraei’s Instagram: https://www.instagram.com/wholistickids/?hl=en
Dr. Pejman Katiraei’s Substack: https://pkatiraei.substack.com/
👩⚕️ About Dr. Jolene Brighten
Dr. Jolene Brighten is a board-certified naturopathic endocrinologist, Certified Menopause Practitioner, nutrition scientist, certified sex counselor, bestselling author, and host of The Dr. Brighten Show. Her work focuses on women’s hormones, reproductive health, ADHD, neurodivergence, perimenopause, menopause, and the complex ways the brain, immune system, gut, and endocrine system interact.
🌐 Dr. Brighten’s Website: https://drbrighten.com
📸 Follow Dr. Brighten on Instagram: https://www.instagram.com/drjolenebrighten/
🎵 Follow Dr. Brighten on TikTok: https://www.tiktok.com/@drjolenebrighten
▶️ Subscribe on YouTube: https://www.youtube.com/@DrJoleneBrighten
📘 Follow Dr. Brighten on Facebook: https://www.facebook.com/drbrighten
⚠️ Medical Disclaimer: This content is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. It does not replace individualized medical advice. Always consult an appropriately qualified healthcare professional regarding symptoms, testing, medications, supplements, environmental concerns, or treatment decisions. Learn more about your ad choices. Vis
More from The Dr. Brighten Show
ADHD medication can feel different across your menstrual cycle, and a difficult month doesn’t automatically mean your treatment has failed. View the show notes and episode resources at https://drbrighten.com/podcast/adhd-medication-and-your-period/ .
ADHD rejection sensitive dysphoria (RSD), women’s mental load, and the relationship fights that never seem to end—this episode explores how ADHD can affect communication, friendship, intimacy, and the stories we tell ourselves about being “too much.” View the full show notes and resources at DrBrighten.com: https://drbrighten.com/podcast/adhd-and-relationships/
ADHD and hormones are deeply connected, and shifts in estrogen, progesterone, and testosterone may help explain why focus, mood, executive function, and even the experience of ADHD medication can change across the menstrual cycle and during perimenopause. View the full show notes and additional resources at https://drbrighten.com/podcasts/adhd-hormones-in-women/.
ADHD in women symptoms can hide behind straight As, a successful career, a packed calendar, and the exhausting work of appearing “fine.” In Episode 1 of the ADHD in Women series, Dr. Jolene Brighten joins psychiatrist Dr. Agnes Kwon Simone, pediatric psychologist Dr. Ann-Louise Lockhart, and clinical s/xologist Dr. Leann Borneman to unpack the signs women mask, the assessment gaps that lead to missed diagnoses, and how to advocate for a thorough evaluation. View the full show notes at https://drbrighten.com/podcasts/adhd-in-women-symptoms/ .
Did you know women with endometriosis are twice as likely to be diagnosed with ADHD? In my new book, ADHD and Women, I connect the dots between hormones, pain, mood, focus, and the symptoms women are too often told to simply push through—so you can finally understand what is happening in your body and brain. Get your copy: https://drbrighten.com/adhd-and-women/