CrashCourse

More EAS - Electron Donating and Withdrawing Groups: Crash Course Organic Chemistry #38

CrashCourse

Show Notes

In the previous episode we discussed what happens when we use electrophilic aromatic substitution to add a group to a benzene ring, but what happens when you try to add even more groups? Well, things get a little more complicated. In this episode of Crash Course Organic Chemistry, we’ll continue our exploration of EAS reactions by looking at electron donating groups and electron withdrawing groups on benzene, and how they affect what happens when we try to add new groups to the ring.Episode Sources:Hammond, G.S. and Douglas, K.J., 1959. Aromatic nitration. III. The ortho to para ratio in nitration of benzonitrile. Journal of the American Chemical Society, 81(5), pp.1184-1187.Series Sources:Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, Boston, 2018.Bruice, P. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., United States, 2014.Clayden, J., Greeves, N., Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, New York, 2012.Jones Jr., M.; Fleming, S. A., Organic Chemistry, 5th ed.; W. W. Norton & Company, New York, 2014. Klein., D., Organic Chemistry; 1st ed.; John Wiley & Sons, United States, 2012.Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publishers, Colorado, 2009.McMurry, J., Organic Chemistry, 9th ed.; Cengage Learning, Boston, 2016.Smith, J. G., Organic chemistry; 6th ed.; McGraw-Hill Education, New York, 2020.Wade., L. G., Organic Chemistry; 8th ed.; Pearson Education, Inc., United States, 2013.***Watch our videos and review your learning with the Crash Course App! Download here for Apple Devices: https://apple.co/3d4eyZoDownload here for Android Devices: https://bit.ly/2SrDulJCrash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourseThanks to the following patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:Shannon McCone, Amelia Ryczek, Ken Davidian, Brian Zachariah, Stephen Akuffo, Toni Miles, Oscar Pinto-Reyes, Erin Nicole, Steve Segreto, Michael M. Varughese, Kyle & Katherine Callahan, Laurel A Stevens, Vincent, Michael Wang, Stacey Gillespie, Jaime Willis, Krystle Young, Michael Dowling, Alexis B, Rene Duedam, Burt Humburg, Aziz, DAVID MORTON HUDSON, Perry Joyce, Scott Harrison, Mark & Susan Billian, Junrong Eric Zhu, Alan Bridgeman, Rachel Creager, Jennifer Smith, Matt Curls, Tim Kwist, Jonathan Zbikowski, Jennifer Killen, Sarah & Nathan Catchings, Brandon Westmoreland, team dorsey, Trevin Beattie, Divonne Holmes à Court, Eric Koslow, Jennifer Dineen, Indika Siriwardena, Khaled El Shalakany, Jason Rostoker, Shawn Arnold, Siobhán, Ken Penttinen, Nathan Taylor, William McGraw, Andrei Krishkevich, ThatAmericanClare, Rizwan Kassim, Sam Ferguson, Alex Hackman, Jirat, Katie Dean, neil matatall, TheDaemonCatJr, Wai Jack Sin, Ian Dundore, Matthew, Justin, Jessica Wode, Mark, Caleb Weeks__Want to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashCourseTwitter - http://www.twitter.com/TheCrashCourseTumblr - http://thecrashcourse.tumblr.com Support Crash Course on Patreon: http://patreon.com/crashcourseCC Kids: http://www.youtube.com/crashcoursekids Learn more about your ad choices. Visit megaphone.fm/adchoices

More from CrashCourse

Oct 28, 2026

You're already learning on YouTube — why not get college credit for it? https://link.gostudyhall.com/my1 In this episode of Crash Course: How to College, Erica talks us through what preparing for college could entail and how we can be active in that preparation. Applying to college is exciting and stressful and lots of other things that cause a whole lot of emotions. But you can take steps now that will make the college admissions process a lot easier once you get to that point.***Now you can take top-tier college courses with Study Hall! Study Hall videos are available to watch at no cost, and first-year courses are $25 to sign-up and begin coursework. Once you're satisfied with your grade, receive credit for only $400. Sign up at https://link.gostudyhall.com/my1 Follow Study Hall on socials! Twitter: https://twitter.com/gostudyhallInstagram: https://Instagram.com/GoStudyHallFacebook: https://www.facebook.com/GoStudyHall _______________________________________________Chapters: 0:00 - Introduction 0:51 - Getting organized 1:24 - Goals 2:25 - Courses 3:36 - Standardized tests6:12 - Figuring out your interests_______________________________________________Links to the resources listed in this video:GED: https://ged.com/Kaplan: https://www.kaptest.com/study/Career assessment tests: https://www.careeronestop.org/ https://www.mynextmove.org/explore/ipNational College Attainment Network: https://www.ncan.org/general/custom.asp?page=MemberDirectoryUpward Bound: https://www2.ed.gov/programs/trioupbound/index.htmlCrash Course: How to College is part of Study Hall, a partnership between ASU and Crash Course. Head over to our new Study Hall channel to check out our Fast Guide series which break down different college majors. ***Watch our videos and review your learning with the Crash Course App! Download here for Apple Devices: https://apple.co/3d4eyZoDownload here for Android Devices: https://bit.ly/2SrDulJCrash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourseThanks to the following patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:Dave Freeman, Hasan Jamal, DL Singfield, Lisa Owen, Jeremy Mysliwiec, Amelia Ryczek, Ken Davidian, Stephen Akuffo, Toni Miles, Erin Switzer, Steve Segreto, Michael M. Varughese, Kyle & Katherine Callahan, Laurel Stevens, Vincent, Michael Wang, Stacey Gillespie (Stacey J), Alexis B, Burt Humburg, Aziz Y, Shanta, DAVID MORTON HUDSON, Perry Joyce, Scott Harrison, Mark & Susan Billian, Junrong Eric Zhu, Rachel Creager, Breanna Bosso, Matt Curls, Tim Kwist, Jonathan Zbikowski, Jennifer Killen, Sarah & Nathan Catchings, team dorsey, Trevin Beattie, Divonne Holmes à Court, Eric Koslow, Jennifer, Dineen, Indika Siriwardena, Khaled El Shalakany, Jason Rostoker, Shawn Arnold, Siobhán, Ken Penttinen, Nathan Taylor, Les Aker, ClareG, Rizwan Kassim, Alex Hackman, Jirat, Katie Dean, Avi Yashchin, NileMatotle, Wai Jack Sin, Ian Dundore, Justin, Mark, Caleb Weeks__Want to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashC...Twitter - http://www.twitter.com/TheCrashCourseTumblr - http://thecrashcourse.tumblr.com Support Crash Course on Patreon: http://patreon.com/crashcourseCC Kids: http://www.youtube.com/crashcoursekids"#CrashCourse #HowtoCollege #StudyHall Learn more about your ad choices. Visit megaphone.fm/adchoices

Oct 28, 2026

We’ve already learned the basics of carbonyl chemistry and talked about how we can synthesize aldehydes and ketones, but there’s still so much more to learn, like the role carbonyl groups play in reactions involving sedatives! In this episode of Crash Course Organic Chemistry we’re diving deeper into aldehydes and ketones by focusing on addition reactions of oxygen and nitrogen based nucleophiles. We’ll cover hydrates, acetals and hemiacetals, imines and enamines, and more!Episode Sources:io9. 2020. This Is The Drug In The Rolling Stones' Song "Mother's Little Helper". [online] Available at: https://io9.gizmodo.com/this-is-the-drug-in-the-rolling-stones-song-mothers-li-1693032181 Bionity.com. 2020. Mickey_Finn_(Drugs). [online] Available at: https://www.bionity.com/en/encyclopedia/Mickey_Finn_%28drugs%29.html#The_Chicago_bartender_Michael_.22Mickey.22_Finn Chm.bris.ac.uk. 2020. Ninhydrin - Molecule Of The Month - April 2018. [online] Available at: http://www.chm.bris.ac.uk/motm/ninhydrin/ninhydrinh.htmEwan, H.S., Iyer, K., Hyun, S.H., Wleklinski, M., Cooks, R.G. and Thompson, D.H., 2017. Multistep flow synthesis of diazepam guided by droplet-accelerated reaction screening with mechanistic insights from rapid mass spectrometry analysis. Organic Process Research & Development, 21(10), pp.1566-1570.Series Sources:Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, Boston, 2018.Bruice, P. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., United States, 2014.Clayden, J., Greeves, N., Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, New York, 2012.Jones Jr., M.; Fleming, S. A., Organic Chemistry, 5th ed.; W. W. Norton & Company, New York, 2014. Klein., D., Organic Chemistry; 1st ed.; John Wiley & Sons, United States, 2012.Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publishers, Colorado, 2009.McMurry, J., Organic Chemistry, 9th ed.; Cengage Learning, Boston, 2016.Smith, J. G., Organic chemistry; 6th ed.; McGraw-Hill Education, New York, 2020.Wade., L. G., Organic Chemistry; 8th ed.; Pearson Education, Inc., United States, 2013.***Watch our videos and review your learning with the Crash Course App! Download here for Apple Devices: https://apple.co/3d4eyZoDownload here for Android Devices: https://bit.ly/2SrDulJCrash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourseThanks to the following patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:Vincent, Emilee Murphy, Michael Wang, Jordan willis, Krystle Young, Michael Dowling, Alexis B, Rene Duedam, Burt Humburg, Aziz, Nick, DAVID MORTON HUDSON, Perry Joyce, Scott Harrison, Mark & Susan Billian, Junrong Eric Zhu, Alan Bridgeman, Rachel Creager, Jennifer Smith, Matt Curls, Tim Kwist, Jonathan Zbikowski, Jennifer Killen, Sarah & Nathan Catchings, Brandon Westmoreland, team dorsey, Trevin Beattie, Divonne Holmes à Court, Eric Koslow, Indika Siriwardena, Khaled El Shalakany, Shawn Arnold, Siobhán, Ken Penttinen, Nathan Taylor, William McGraw, Andrei Krishkevich, Sam Ferguson, Eric Prestemon, Jirat, TheDaemonCatJr, Wai Jack Sin, Ian Dundore, Jason A Saslow, Justin, Jessica Wode, Mark, Caleb Weeks__Want to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashCourseTwitter - http://www.twitter.com/TheCrashCourseTumblr - http://thecrashcourse.tumblr.com Support Crash Course on Patreon: http://patreon.com/crashcourseCC Kids: http://www.youtube.com/crashcoursekids Learn more about your ad choices. Visit megaphone.fm/adchoices

Oct 28, 2026

In which John Green teaches you about railroads and some of the ways they changed the world, and how they were a sort of microcosm for the Industrial Revolution as a whole. Prior to the invention of steam-powered railroads, pretty much all locomotion had been muscle-powered. You either walked where you wanted to go or rode on an animal to get where you were going. The railroad changed human perception of time and space, making long-distance travel much faster and easier. Railroads also changed habits, including increasing reading. People needed some sort of distraction to ensure they didn't have to talk to other people on the train. Like any new technology, railroads also scared people. All kinds of fears surrounded rail travel, but over time, people got over them. And the quality of boiler manufacturing improved, so the trains exploded less often, which also made people feel safer. Crash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourseWant to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashCourseTwitter - http://www.twitter.com/TheCrashCourseInstagram - https://www.instagram.com/thecrashcourse/CC Kids: http://www.youtube.com/crashcoursekids Learn more about your ad choices. Visit megaphone.fm/adchoices

Oct 28, 2026

You might think a self regulating factory sounds pretty unbelievable, but that’s pretty much exactly how our bodies work! Our bodies are full of regulatory mechanisms that keep all the organic molecules we need to live in balance. In this episode of Crash Course Organic Chemistry, we’ll look at the building blocks that form these biological polymers, including carbohydrates, proteins, and DNA!Episode Sources:Garrett, R. H., & Grisham, C. M. (2016). Biochemistry. Cengage Learning.Appling, Dean R., Anthony-Cahill, Spencer J., Mathews, Christopher K.. (2016). Biochemistry: concepts and connections. Essex: Pearson.PDB IDs (available at https://www.rcsb.org/): • 1BNA, 6TNA, 3MQ7, 7BJK, 6EC0, 2D3H, 1UBQ, 1BBB, 3FGUSeries Sources:Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, Boston, 2018.Bruice, P. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., United States, 2014.Clayden, J., Greeves, N., Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, New York, 2012.Jones Jr., M.; Fleming, S. A., Organic Chemistry, 5th ed.; W. W. Norton & Company, New York, 2014. Klein., D., Organic Chemistry; 1st ed.; John Wiley & Sons, United States, 2012.Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publishers, Colorado, 2009.McMurry, J., Organic Chemistry, 9th ed.; Cengage Learning, Boston, 2016.Smith, J. G., Organic chemistry; 6th ed.; McGraw-Hill Education, New York, 2020.Wade., L. G., Organic Chemistry; 8th ed.; Pearson Education, Inc., United States, 2013.***Watch our videos and review your learning with the Crash Course App! Download here for Apple Devices: https://apple.co/3d4eyZoDownload here for Android Devices: https://bit.ly/2SrDulJCrash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourseThanks to the following patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:April Frazier, Dave Freeman, Hasan Jamal, DL Singfield, Lisa Owen, Jeremy Mysliwiec, Amelia Ryczek, Ken Davidian, Stephen Akuffo, Toni Miles, Steve Segreto, Michael M. Varughese, Kyle & Katherine Callahan, Laurel Stevens, Vincent, Michael Wang, Stacey Gillespie (Stacey J), Alexis B, Burt Humburg, Aziz Y, Shanta, DAVID MORTON HUDSON, Perry Joyce, Scott Harrison, Mark & Susan Billian, Junrong Eric Zhu, Rachel Creager, Breanna Bosso, Matt Curls, Tim Kwist, Jonathan Zbikowski, Jennifer Killen, Sarah & Nathan Catchings, team dorsey, Trevin Beattie, Divonne Holmes à Court, Eric Koslow, Jennifer Dineen, Indika Siriwardena, Khaled El Shalakany, Jason Rostoker, Shawn Arnold, Siobhán, Ken Penttinen, Nathan Taylor, Les Aker, ClareG, Rizwan Kassim, Sam Ferguson, Alex Hackman, Jirat, Katie Dean, Avi Yashchin, NileMatotle, Wai Jack Sin, Ian Dundore, Justin, Mark, Caleb Weeks__Want to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashCourseTwitter - http://www.twitter.com/TheCrashCourseTumblr - http://thecrashcourse.tumblr.com Support Crash Course on Patreon: http://patreon.com/crashcourseCC Kids: http://www.youtube.com/crashcoursekids Learn more about your ad choices. Visit megaphone.fm/adchoices

Oct 28, 2026

In which John Green, Hank Green, and Emily Graslie teach you about evolution. So, in the last 3.8 billion years, life on Earth has evolved from single-celled prokaryotes to the dizzying array of life we have today. So how did all this happen? We'll talk about Darwin, evolution, natural selection, and how we got from there to here, and from then to now. Learn more here: http://www.bighistoryproject.comCrash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourseWant to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashCourseTwitter - http://www.twitter.com/TheCrashCourseInstagram - https://www.instagram.com/thecrashcourse/CC Kids: http://www.youtube.com/crashcoursekids Learn more about your ad choices. Visit megaphone.fm/adchoices

See all episodes →