Show Notes
These two doctors are building a clinic where the most advanced longevity therapies have no limits. Dr. Alexander Grinberg (Infinity Epigenetics, San Francisco) and Dr. Dave Jenkins (Bredesen-trained, 40+ years clinical experience) are combining peptide therapy, regenerative medicine, and personalised protocols at a level most people don't know exists. From Klotho protein restoring cognitive function in head injury patients to mitochondrial peptides that can rescue dying cells — this conversation covers the cutting edge of what's actually possible right now. About the Guests Dr. Alexander Grinberg MD is a physician, immunologist, and peptide therapy specialist practicing in San Francisco. He holds a fellowship from the Moscow Immunology Institute and consults internationally on advanced customised longevity protocols. He runs Infinity Epigenetics and teaches physicians in high-end integration of peptides, regenerative medicine, and genetic therapies. Dr. Dave Jenkins is a New Zealand-trained physician with 40+ years of clinical experience specialising in metabolic and neurological health. He is Bredesen Protocol (ReCODE) trained and runs a longevity clinic in Bali. He co-developed a Type 2 Diabetes reversal program now being published and reviewed by NZ's top diabetic specialists. In this episode Why Klotho protein may be one of the most powerful longevity interventions available — and the different delivery forms (protein injection, peptide fragments, gene therapy) Dr. Dave's clinical Klotho results: a doctor with chronic head injury returning to practice, and his own memory score jumping from the 66th to the 97th percentile in six weeks How mitochondrial peptides (MOTS-c, SS-31, Humanin) work and why dosing wrong can be dangerous — especially in autoimmune and cancer history cases The case for micro-dosing peptides and why skin testing should come first Personalised medicine taken to its extreme: harvesting a patient's own cells, expanding them in culture, and running accelerated longevity and cancer resilience tests before any intervention Why peptide purity and sourcing is a serious safety concern — and what the clinic will do differently The vision for a Pacific Island longevity clinic offering therapies unavailable in the US, EU, NZ, or Australia — with a social impact mission to address metabolic disease in local populations Off-label repurposed drugs for cancer (metformin, ivermectin, doxycycline, mebendazole) and why the regulatory environment matters How custom peptides designed from a patient's own genome could replace pharmaceuticals entirely Resources mentioned Infinity Epigenetics — infinityepigenetics.com Dr. Dave Jenkins — 🌐 https://youngerbyscience.com/ 🌐 https://theendofalzheimers.com
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Why can one person drink a flat white at 3pm and sleep soundly, while another lies awake until midnight? Why does one glass of wine turn some people bright red? A lot of it comes down to your genes. In this solo episode, I break down the caffeine and alcohol genes I look at in my clients' myDNA reports, what your results can and can't tell you, and the simple changes that follow. In this episode: - How CYP1A2 shapes how long caffeine hangs around, and why your cut-off time matters - What the research shows about caffeine, genetics and athletic performance - ADORA2A, and why some people feel caffeine far more strongly than others - The ALDH2 variant behind the alcohol flush, and why it matters for more than a red face - The ripple effects: vitamin B1, REM sleep, APOE, and the unfiltered coffee and cholesterol link - Why genetics loads the gun, and environment pulls the trigger Find out what your genes say with my DNA Blueprint Package, available in New Zealand, Australia and the USA: genetics, DNA test, nutrigenomics, myDNA, caffeine, coffee, alcohol, alcohol flush, red face after drinking, ALDH2, CYP1A2, ADORA2A, APOE, caffeine metabolism, sleep, REM sleep, thiamine, vitamin B1, cholesterol, longevity, personalised health, functional medicine, Lisa Tamati, Pushing the Limits More on thiamine: my full interview with Elliot Overton https://www.youtube.com/watch?v=8qwb_XmDqqk Chapters: 0:00 Same coffee, different genes 0:18 Why blanket health advice fails 1:00 Your caffeine gene: CYP1A2 2:48 Caffeine, sleep and the cut-off 3:27 Caffeine and athletic performance 4:34 ADORA2A: how strongly you feel caffeine 5:35 Alcohol and the ALDH2 gene 7:45 Ripple effects: B1, sleep, APOE and coffee 10:25 Genes load the gun 11:14 Your next step Educational content only. Genetics shows tendencies and priorities, not diagnoses.
I ran 70,000km across the world's toughest deserts to lose weight, and I got heavier, more inflamed and sicker every year. I assumed the problem was discipline. It took one genetic test to show me it never was. In this solo episode I make the case that your DNA is the single most valuable test you will ever do. Not because it tells you the most, but because it is the only test whose result is still true in fifty years. Your bloods reflect the last few weeks. Your microbiome shifts with every trip and every course of antibiotics. Your hormones move across the month and the decade. Your DNA does not move at all. I go through all eight areas a comprehensive genetic panel covers, what you actually learn from each one, and why a variant is a tendency rather than a verdict. IN THIS EPISODE My own results, and the cascade that explains twenty-five years of getting it wrong Why genetics is different from every other test you will ever do Genetics loads the gun, environment pulls the trigger: what that actually means in practice The single-gene trap, and why the MTHFR obsession has it upside down Digestion, energy, hormones, stress and cognition, inflammation, athletic performance, DNA repair and detoxification, one at a time The difference between nutritional dosing and nutrigenomic dosing, and why more vitamin D was not working for me Why genetics alone is not enough, and what has to sit alongside it Why it is almost never discipline THE DNA BLUEPRINT PACKAGE Practitioner-only genetic testing, ninety-two genes and a hundred and thirteen variants across a report of roughly a hundred and twenty-one pages, read by me alongside a full Cell Blueprint assessment and turned into a complete personal health programme in a ninety-minute one-on-one. Available throughout New Zealand. Australia coming soon. https://www.lisatamati.com/dna/ GO DEEPER Dr Sam Shay on methylation, inflammation and exercise-induced obesity: https://www.lisatamati.com/podcast--dr-sam-shay_1/ Dr Mansoor Mohammed on how your variants change what you eat and how you train: https://www.lisatamati.com/podcast-mansoor-mohammed/ Read the long-form article: https://www.lisatamati.com/blog/ ALSO FROM LISA Re:juvenate Pro, the foundational immune ageing formula from Aevum Labs: https://shop.lisatamati.com/pages/rejuvenate Re:NRG, our next-generation NAD support, is coming. Join the waitlist for first access: https://shop.lisatamati.com/pages/nad-next-gen-waitlist Weekly longevity insights, free: https://www.lisatamati.com/lisa Questions or feedback: [email protected] Pushing the Limits is hosted by Lisa Tamati, genetics practitioner, co-founder and Chief Science Officer of Aevum Labs, and former professional ultra-endurance athlete. Author of three books and one audiobook.
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The link between micronutrients and mental health is one of the most overlooked stories in modern medicine, and Professor Julia Rucklidge has spent more than two decades proving it matters. In this episode of Pushing the Limits, she shares the research on micronutrients and mental health that has challenged psychiatry's drug-first model, showing that broad-spectrum vitamins and minerals can treat ADHD, depression and anxiety, often as effectively as medication and without the side effects. If you have ever wondered how deeply micronutrients and mental health are connected, this conversation will change how you think about your brain, your mood and the food you eat every day. Professor Julia Rucklidge is a clinical psychologist at the University of Canterbury and Director of Te Puna Toiora, the Mental Health and Nutrition Research Lab. She is co-author, with Bonnie Kaplan, of The Better Brain, and her work has been published in leading psychiatry journals and viewed by millions through her TEDx talk. She came into this field as a sceptic, trained to believe that nutrition was irrelevant to the brain, and changed her mind only when the evidence became impossible to ignore. In this conversation, Julia explains what her clinical trials actually found, and why 60 to 80 percent of people respond to a broad-spectrum approach once you move past the noise of a blinded study. We talk about why feeding the whole system beats chasing a single nutrient, what the biomarkers reveal about inflammation, methylation and the microbiome, and why the RDAs were never designed to support an optimally functioning brain. She makes the case that the recommended daily allowances we rely on were built to prevent deficiency diseases, not to help the brain thrive, and that this gap matters enormously for anyone struggling with their mental health. We also explore the bigger forces at play: depleted soils and what modern agriculture has done to the nutrient density of our food, the rise of ultra-processed food and why Julia calls it the cigarette of the twenty-first century, and the antidepressant withdrawal that so many people are never warned about. She shares her frustration with New Zealand's outdated supplement regulations, where a product can be effectively banned for containing a fraction too much of a nutrient, and a distributor can be threatened with serious penalties for selling something that genuinely works. Most of all, this is a hopeful conversation. It is about taking back control of your health through the food on your plate, understanding the real connection between what you eat and how you feel, and recognising that small, consistent changes can have a profound effect on the brain. Whether you are a parent navigating a child's behaviour, someone managing your own mental health, or simply curious about the science of nutrition and the brain, this episode will give you a new lens on what is possible. If you have ever been told that nutrition is irrelevant to your brain, this episode is for you. Resources and mentions: The Better Brain by Bonnie Kaplan and Julia Rucklidge What Your Food Ate by David Montgomery and Anne Biklé Te Puna Toiora, Mental Health and Nutrition Research Lab, University of Canterbury Biography:
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