ON CRISPR: The Story of Jennifer Doudna with Walter Isaacson

ON BENJAMIN FRANKLIN Episode 3: Industry

ON CRISPR: The Story of Jennifer Doudna with Walter Isaacson

Show Notes

Few people remember that Benjamin Franklin was America’s wealthiest self-made man. After being denied a formal education and then indentured to his own brother, he launched America's first media empire. But while Franklin could be a ruthless businessman, he was out for more than himself—he knew his success was predicated on a strong middle class, a new, American idea. So he started civic ventures like fire departments, street sweepers, and public libraries. But it wasn't until he became a postmaster that he realized why the colonies needed to band together as a nation. See omnystudio.com/listener for privacy information.

More from ON CRISPR: The Story of Jennifer Doudna with Walter Isaacson

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Here's a great episode from another show on Kaleidoscope's network, What Could Go Right? What happens when our biological need for certainty clashes with an increasingly unpredictable world? Simone Stolzoff, author of How to Not Know, joins host Zachary Karabell to discuss why our modern intolerance for uncertainty is fueling a global anxiety crisis. Rather than seeing the unknown as a threat, Stolzoff argues that uncertainty is the fundamental birthplace of scientific breakthroughs, original art, and human progress.

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What if someone told you that you could skip years of therapy with a few mental tricks? It sounded impossible… until we found Neuro-Linguistic Programming. NLP is a form of hypnosis beloved by everyone from sex cults to the U.S. military to fortune 500 companies–yet almost no one knows it exists. Long before she co-founded NXIVM, hypnotist Nancy Salzman encountered NLP as a radical method for reprogramming the mind. Her story leads us to its inventor, Richard Bandler, a volatile, self-made guru. As we dig into how it took hold in so many places, we face an unsettling possibility: NLP might actually work. See omnystudio.com/listener for privacy information.

Oct 8, 2025

In the four years since the book’s publication, CRISPR has revolutionized the world of medical treatments and possibilities. But our world has changed drastically, too. As AI’s impact grows, U.S scientists are facing funding cuts like never before. For our final episode, we bring you a live conversation between Walter Isaacson and Jennifer Doudna at the New Orleans Book Festival. In her own words, you’ll hear Doudna explain how CRISPR blossomed from an idea to a phenomenon, and the challenges scientists faces in this politically fraught moment. See omnystudio.com/listener for privacy information.

Oct 1, 2025

As the gene editing field kept growing, so did the dangers. Back in 2018, Jennifer Doudna received an email from a Chinese scientist claiming that he had genetically edited two twin babies. The news reverberated across the world and made Doudna and her colleagues urgently consider the implications of what their discovery could mean for humanity. Walter Isaacson sits down with Evan and tells him why the field has always been ripe with ethical questions, and how the COVID-19 pandemic pushed researchers to recalibrate their priorities. See omnystudio.com/listener for privacy information.

Sep 24, 2025

Jennifer Doudna thought she had won the race. She thought she had beaten out all scientific competitors when she and her co-author had shocked the world with their groundbreaking technology for gene editing. But turned out, the race had just gotten fiercer. Walter Isaacson sits down with Evan to talk about how one of the most cutthroat scientific competitions in biotech got started around one goal — making CRISPR work for humans, and getting the credit for it. See omnystudio.com/listener for privacy information.

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