BackTable Cardiology

Ep. 32 Coronary Microvascular Dysfunction: Optimizing Diagnosis & Management with Dr. Samit Shah

BackTable Cardiology

Show Notes

Small vessels can have a major impact. Are you missing the hidden culprit of chest pain? In this episode of BackTable Cardiology, host Dr. Hady Lichaa welcomes Yale Interventional Cardiologist Dr. Samit Shah to discuss Coronary Microvascular Dysfunction (CMD) and Angina with No Obstructive Coronary Arteries (ANOCA). Their discussion demonstrates how coronary function testing turns a historically vague diagnosis into actionable phenotyping that can dramatically improve treatment efficacy and patient symptoms.

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Timestamps

00:00 - Introduction01:53 - Coronary Microvascular Dysfunction (CMD) Overview10:55 - Cath Lab Workflow Tips19:28 - Structural CMD: Discordant CFR and IMR Values26:59 - Vasospastic Phenotypes28:28 - Chest Pain Case: Syncope and Arrest Risk33:31 - Treatment and ACh Testing39:10 - Mixed Physiology Pharmacotherapy49:45 - Myocardial Bridge Workup55:19 - Workflow, Reimbursement, and Future Therapies58:11 - Closing and Signoff

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More about this episode

Dr. Shah breaks down clinical presentations and cath lab findings of epicardial vasospasm, microvascular spasm, and endothelial dysfunction, outlining how phenotype and physiology influence treatment. He explains how to perform both Coronary Flow Reserve (CFR) and Index of Microcirculatory Resistance (IMR) testing, incorporating examples of interpretation of abnormal values. The physicians discuss COVADIS criteria for vasospastic angina, vasospasm and cardiac arrest considerations, and myocardial bridges in LAD-PCI. The episode covers door-to-discharge care for CMD: identification of phenotype via patient case walk-throughs, practical cath lab workflow, and recommendations for tailored pharmacotherapy.

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Resources

Dr. Hady Lichaa’s Provider Profilehttps://healthcare.ascension.org/find-care/provider/1336267533/hady-lichaa

Dr. Samit Shah’s Provider Profile https://medicine.yale.edu/profile/samit-shah/

COVADIS Criteria for vasospastic anginahttps://covadis.online/definitions/

A doppler flow probe for canine main left coronary arterieshttps://journals.physiology.org/doi/abs/10.1152/jappl.1974.37.2.256?journalCode=jappl

ChaMP-CMD: A Phenotype-Blinded, Randomized Controlled, Cross-Over Trialhttps://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.066680

Presence and Relevance of Myocardial Bridge in LAD-PCI of CTO and Non-CTO Lesions

https://pubmed.ncbi.nlm.nih.gov/38340105/

DEFINE GPS Trialhttps://clinicaltrials.gov/study/NCT04451044

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