TWiV 1358: Clinical Update with Dr. Daniel Griffin

TWiV explains a study which shows that influenza A virus infection induces immune dysregulation in the placenta and fetus without vertical transmission in nonhuman primates, and development of an epigenetic silencer therapy to transcriptionally inactivate viral DNA in chronic hepatitis B. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Helen Branswell, 69 (STAT) Influenza A virus and fetal immune dysregulation (Sci Adv) Epigenetic silencing for hepatitis B (Nat Biomed Eng) Letters read on TWiV 1367 Timestamps by Jolene Ramsey. Thanks! Picks of the Week Brianne – A healing touch for coral bleaching Kathy – Saturday Morning Physics especially The Science of Survey Research Rich – Everything is Tuberculosis by John Green Vincent – Death by Black Hole: And Other Cosmic Quandaries by Neil deGrasse Tyson Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Daniel Griffin and Vincent Racaniello are crestfallen to learn of the 6th measles death in Pennsylvania and more than 9000 deaths from Ebola, an enterovirus/Coxsackievirus outbreak at the University of Pennsylvania, decimation of the HIV services following withdrawal of PEPFAR and USAID, role of gut microbes in vaccine adverse events such as fever, continued raw milk consumption, and thermostable nanoparticles for mRNA vaccine delivery before Dr. Griffin deep dives into recent statistics RSV, influenza, SARS-CoV-2 infections, measles, development of a rapid diagnostic for measles, how long COVID effects sleep cycles and the microbiome, and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Hand, foot, and mouth disease cases spike at Penn this fall (The Daily Pennsylvanian) HIV service delivery after the PEPFAR and USAID HIV funding withdrawal in Uganda and Zimbabwe: an interrupted time-series study (LANCET: Global Health) The human gut microbiome primes fever after vaccination (Science) Escape to 11,100' in Rustic Luxury (HaydenBackcountry) Consumption of Unpasteurized (Raw) Milk and Milk Products by Pregnant People and Children: Policy Statement (Pediatrics) Raw milk poses serious infection risks with no added health benefits, pediatrician group warns (CIDRAP) The Science and the Stakes of Raw Milk Consumption with Pam Ruegg, Nicole Martin, and Daniel Griffin (Dairy Digressions) First Birth Cohort Eligible for Chickenpox Vaccine Had a Sharp Drop in Shingles Cases (Epic Research) Accelerated discovery of thermostable mRNA–lipid nanoparticle vaccines using data-efficient AI (Nature: Biotechnology) Legionnaires' Disease (NYC: Health) Dashboard SCREWWORM.Gov (USDA: Animal and Plant Health Inspection Service) CDC Activates Emergency Operations Center for New World Screwworm Response (CDC Newroom) Ebola DRC (X) Ebola dashboard (ebola.fyi) EBOLA: The Democratic Republic of the Congo, 2026 (WHO) Bundibugyo virus disease outbreak Democratic Republic of the Congo(WHO: Democratic Republic of Congo) Ebola Outbreak: Current Situation (CDC:Ebola) Congo's Ebola infections surpass 9,000, government report shows (Reuters) I've Worked in Congo for Decades. I've Never Seen an Ebola Crisis Like This (NY Times) Pennsylvania reports its 6th measles death, in a Franklin County resident (CIDRAP) Subacute Sclerosing Panencephalitis after Measles Outbreaks, the Philippines, 2007–2022 (CDC: Emerging Infectious Diseases) Measles Outbreak in Amish Country Forces Some to Rethink Vaccines (NY Times) Wastewater for measles (WasterWater Scan) Measles cases and outbreaks (CDC Rubeola) Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) Utah measles outbreak response (Utah Department of Health and Human Services) Utah Measles Dashboard (Utah Department of Health and Human Services) Measles (VDH: Virginia Department of Health) Tracking Measles Cases in the U.S. (Johns Hopkins) HAP's Latest News Pa. Launches New Measles Dashboard (Hospital + HealthSystem Association of Pennsylvania) Measles (Commonwealth of Pennsylvania) Measles Dashboard (New York State: Department of Health) Made in Africa: New measles rapid diagnostic tests mark breakthrough for vaccination efforts (GAVI: The Vaccine Alliance) Weekly measles and rubella monitoring (Government of Canada) Measles (WHO) Get the FACTS about measles (NY State Department of Health) Measles (CDC Measles (Rubeola)) Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) Deaths following vaccination

TWiV travels to Porto, Portugal for the annual meeting of the European Society for Clinical Virology, where he speaks with Catherine and Corinne about their work on the Andes virus outbreak on the MV Hondius. Host: Vincent Racaniello Guests: Catherine Houlihan and Corinne Guerts van Kessel Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Transient Andes RNA detection in asymptomatic healthcare worker (Eurosurveill) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Daniel Griffin and Vincent Racaniello discuss their continuing struggle to understand the ongoing outbreak of cyclospora, decimation of US public health including 30% or greater loss of personnel from the CDC, continuing measles outbreaks here and aboard, a mumps outbreak in San Diego and a Hib death in Montana, criminalization of pediatricians in Texas, dengue associated death in Florida, Ebola in Kenya, a new Legionnaires outbreak, screw worm cases, and a hearing in Florida to end requirements of four vaccines including Hib and chickenpox, before Dr. Griffin deep dives into recent statistics RSV, influenza, SARS-CoV-2 infections, the continued measles outbreak in Pennsylvania, US, Canada, statistics on vaccine preventable disease mortality in children, effectiveness of adjuvanted high dose influenza vaccine and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Smallpox History and Decisive Actions of George Washington (CDC: Emerging Infectious Diseases) Christina Jewett (NY Times) Caroline Hopkins Legaspi (NY Times) F.D.A. Found Cyclospora During Taylor Farms Inspection in Mexico (NY Times) Suspected plague incident leaves 1 dead, 200 under quarantine in Siberia (CIDRAP) Dozens quarantined in Siberia after plague institute lab worker dies (Reuters) Russia tells WHO there are no plague cases in Siberian city (Reuters) 30% effective workforce loss across CDC (AFGE Local 2883) CDC Leadership (CDC: About CDC) CDC Leadership 2025 (CDC) They Fought Outbreaks Worldwide. Now They're Fighting for New Lives. (NY Times) 'Zombified' C.D.C., Hobbled by Cuts, Struggles to Fulfill Scientific Mission(NY Times) San Diego State football hit by mumps outbreak with 14 confirmed cases ahead of Pac-12 opener (CBS Sports) Texas Pediatricians Face Paxton Investigations for Vaccinating Children (NY Times) Montana DPHHS reports pediatric death from complications of invasive Hib infection (NBC: Montana) Florida announces Oct. 8 hearing on plan to end rules for four vaccines (WUSF: NPR Health News Florida) Legionnaires' Disease (NYC: Health) 2 confirmed cases of Legionnaires' disease at Queens apartment complex prompt NYC Health Department probe (CBS News) Dashboard SCREWWORM.Gov (USDA: Animal and Plant Health Inspection Service) CDC Activates Emergency Operations Center for New World Screwworm Response (CDC Newroom) Kenya Records Ebola Case for First Time (NY Times) Ebola DRC (X) Ebola dashboard (ebola.fyi) EBOLA: The Democratic Republic of the Congo, 2026 (WHO) Bundibugyo virus disease outbreak Democratic Republic of the Congo (WHO: Democratic Republic of Congo) Ebola Outbreak: Current Situation (CDC:Ebola) Hochul Declares a Measles Emergency as Cases Rise in Rural New York( NY Times) Pediatric Deaths during Measles Outbreak, Jerusalem, Israel, 2025–2026 (CDC: Emerging Infectious Diseases) Small quantity lipid-based nutritional supplementation and measles vaccination coverage in children aged 6−23 months: a pragmatic cluster-randomized trial (Nature Medicine) Measles Outbreak in Amish Country Forces Some to Rethink Vaccines (NY Times) Wastewater for measles (WasterWater Scan) Measles cases and outbreaks (CDC Rubeola) Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) Utah measles outbreak response (Utah Department of Health and Human Services) Utah Measles Dashboard (Utah Department of Health and Human Services) Measles (VDH: Virginia Department of Health) Tracking Measles Cases in the U.S. (Johns Hopkins) HAP's Latest News Pa. Launches New Measles Dashboard (Hospital + HealthSystem Association of Pennsylvania) Measles (Commonwealth of Pennsylvania) Measles Dashboard (New York State: Department of Health) Governor Hochul Declares State Disaster Emergency in Response to Ongoing Measles Outbre

TWiV explains a study testing how 16 hypothesized social and environmental drivers impact disease outbreaks, concluding that infectious disease spillover and emergence are multi-causal, and that no one-size-fits-all strategy can prevent epidemics and pandemics, and an analysis of Myotis bats, which shows that their remarkable longevity and immunity are linked through pleiotropic adaptations to viruses and aging-related disease. Hosts: Vincent Racaniello, Alan Dove, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Virus Appreciation Day (Day of the Year) Anthropogenic fingerprint on emerging infectious diseases (Nature) Longevity and virus-driven adaptations in Myotis bats (Nature) Letters read on TWiV 1363 Timestamps by Jolene Ramsey. Thanks! Picks of the Week Angela – Birds. Alan – Halloween t-shirts from my local animal shelter. Vincent – A Thousand Brains by Jeff Hawkins Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.