Hack You

Brad Schoenfeld: The Science Of Building Muscle & Maximising Strength

Hack You

Show Notes

Brad Schoenfeld has published over 200 peer-reviewed studies on muscle hypertrophy, and his research reveals why most people are training with far less volume than optimal, but adding more sets isn't always the answer.

After analysing decades of resistance training data, Brad discovered that the relationship between volume and muscle growth follows a dose-response curve with a point of diminishing returns that varies dramatically between individuals. While some respond to 6 sets per muscle group per week, others need 20+ sets to maximise growth, and the difference comes down to factors most trainers never consider when programming.

Tune in to find out your optimal training volume, why the "10 sets per muscle group" recommendation is oversimplified, and the specific markers that tell you when you've crossed from productive to junk volume.

00:00 Introduction 04:11 Understanding optimal training volume and individual variability 09:01 Effective rep ranges and importance of training to near failure 13:09 Mixing rep ranges for hypertrophy and the science behind it 15:11 Myths debunked by research including rest times and nutrient timing 18:23 Clarifying protein timing and muscle protein synthesis windows 23:00 Does lifting tempo matter and how to think about it 27:23 Eccentric vs concentric movement and site-specific muscle growth 30:15 Advanced techniques like eccentric overload and when to use them 31:43 Designing a hypertrophy programme with just three sessions a week 36:07 The hype and nuance behind training in the lengthened position 40:28 Longevity benefits of resistance training beyond aesthetics 45:06 Muscle memory explained from neurological and cellular angles 47:09 How to adjust training for older individuals 49:07 Signs you're under-recovered and when to back off 50:49 The future of hypertrophy training through genetic profiling

DISCLAIMER Nothing shared on this podcast is a substitute for professional medical guidance. Please consult a healthcare professional before making any health or lifestyle changes.

Hack You Media → Instagram: https://www.instagram.com/hackyoumedia/ → TikTok: https://www.tiktok.com/@hack.you.media?lang=en → More from Hack You: https://hackyou.media/#aa19104a-abc1-4697-b0f5-0e81e47e60c5

» Follow Vadim« Instagram: https://www.instagram.com/vadim_bioniq/?hl=en Bioniq: https://www.bioniq.com/

» Follow Mike« YouTube: youtube.com/MikeThurston Instagram: https://www.instagram.com/mikethurston/?hl=en First Things THRST: youtube.com/FirstThingsThrst

» Follow Brad« Instagram: https://www.instagram.com/bradschoenfeldphd/ Website: https://linktr.ee/bradschoenfeld

More from Hack You

Oct 22, 2026

Dr Olli Sovijärvi is a medical doctor and biohacker who’s spent 13 years researching how to actually reverse ageing. He breaks down why your NAD levels matter, why the basics (grounding, sunlight, movement) always win, and why living in a megacity is fighting biology itself.

Oct 1, 2026

Dean Henry returns for a conversation on all things bioregulators and breaks down why they're a different category of peptides altogether.

Sep 8, 2026

Dr Darren Candow has published over 1000 peer-reviewed studies on creatine, and he's found something surprising: the optimal dose depends entirely on what you're trying to achieve, and it's probably not what you've been taking.

Sep 1, 2026

Dr Jeremy London is a cardiovascular surgeon who breaks down why blood vessel health matters infinitely more than your heart rate, the ecosystem most cardiologists ignore, and why extreme endurance training and steroids create the exact same cardiac damage. Find out what you can actually change starting tomorrow and why VO2 max isn't the only number worth tracking.

Aug 25, 2026

Nathan Carvalho calls himself a human optimisation architect because most people are getting the sequence wrong. He spends weeks connecting the dots between your gut doctor, thyroid doctor, trainer, and nutritionist - people who don't talk to each other but should.

See all episodes →