LIVE from Chicago: 2025 NACCT Research Review – Insights from the North American Congress of Clinical Toxicology
The Poison LabShow Notes
Show Notes In this special live episode from the 2025 North American Congress of Clinical Toxicology (NACCT), Ryan takes you inside the conference to hear directly from the researchers themselves. Covering 11 abstracts that span high-stakes management decisions, surprising case reports, and challenges to toxicology dogma, this year’s highlights feature everything from amlodipine overdoses to naturopathic misadventures, metformin-associated blindness, and more. The show kicks off with a foreword from Ryan and Dr. Jon Cole (abstract co-chair for AACT) discussing some of their favorite research from the conference. If you couldn’t make it to NACCT or just want to catch up on some of the most impactful new research in our field, this episode will give you a front-row seat. Check below for links to the published abstracts, the full list of studies discussed, and timestamps for where you can hear each one. Link to published abstract manuscript Foreword with Dr. Jon Cole 10:43 #7. Is beta blocker toxicity associated with hypoglycemia? Lead author: Dr. Megan Audette, MD
18:17 #237. V-A ECMO as a treatment for vasoplegic shock in amlodipine poisoning: a comparison Lead author: Dr. Daniel Tirado, MD
27:59 #247. Blocked but not beaten: ECMO’s role in severe amlodipine toxicity – a poison center case series Lead author: Dr. Carlos Saldarriaga, MD
28:18 #26. Amlodipine double-dose therapeutic errors reported to Poison Centers Lead author: Johanne Freeman
30:38 #27. Dosing on the edge: unpacking inadvertent amlodipine ingestions reported to a single poison center Lead author: Dr. Tiana Patriarca, PharmD
34:03 #292. Intravenous administration of sodium zirconium cyclosilicate resulting in death Lead author: Dr. Stephen Thornton, MD
Researcher interviews 44:16 – #21. Quantitative analysis of amlodipine removal by plasmapheresis Guest: Dr. Keahi Horowitz, MD – Acute and Intensive Care Research Award winner
48:33– #23. Relationship between reported ingestion dose and outcome in amlodipine poisoning Guest: Dr. Colleen Cowdery, MD
51:37 – #24. Management of severe amlodipine toxicity with high-dose calcium alone Guest: Dr. Vincent Ma, MD High dose norepinephrine in amlodipine overdose Case report of calcium death
56:56– #70. Iatrogenic exposure to long-acting buprenorphine injectable in an opioid-naïve patient Guest: Dr. Conor Young, MD
01:00:11 – #182. Left in the dark: a case of blindness in the setting of metformin toxicity Guest: Dr. Madison Bombard, MD
01:12:11 – #169. Just because it’s natural doesn’t mean it’s safe: a case of pediatric toxicity from topical and herbal remedies Guest: Dr. Aria Darling, MD
01:04:31 – #203. Serotonin syndrome after vaping Moocah Guest: Dr. Connor Murphy, MD
01:07:06 – #307. Intravenous ozone autohemotherapy: a retrospective observational case series Guest: Nicole McLarty
01:11:25 – #134. Do they really need n-acetylcysteine? Exploratory analysis of outcomes in patients with elevated liver function tests but no detectable acetaminophen Guest: Dr. Seth Carroll, PharmD
01:15:33 – #130. Outcomes of acute acetaminophen-poisoned patients treated with and without fomepizole: a Toxic registry study Guest: Dr. Jordan Woollum, PharmD
01:21:23 – #295. Evaluation of onset and resolution of complications after chronic methotrexate poisoning Guest: Dr. Van Quach, PharmD
01:24:51 – #325. Implications of potassium in salicylate toxicity treated with urinary alkalinization Guest: Dr. Andrew Yetka, PharmD
Bonus Content Stick around to the very end of the episode for a teaser of Stump the Tox and the brand-new game Tox Wavelength, recorded on the train to NACCT. The full episode is available now for supporting members.
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A quick Poison Lab update: new episodes are in the works, including a forthcoming NACCT research episode—though Ryan is briefly buried under mushroom-poisoning programming, NACCT, travel, and the start of a new academic year. In the meantime, revisit the back catalog, including outbreak episodes, Toxicologists Versus the Internet, and favorites such as “Should We Give Naloxone in Cardiac Arrest?” and “Leafy Greens and Injured Beans: Nature’s Nephrotoxins.” As a bonus, this episode includes Ryan’s interview with the podcast from the journal Addiction, discussing his recent study on kratom regulation and medical outcomes. For a more informal companion conversation, check out the “Co-Broadcast with the Kratom Sobriety Podcast” episode. A Morel Dilemma Support the show Review the show where ever your listening Get Messages from Toxo (Join the Newsletter!) Join as a supporting member Ad free episodes Bonus content and early access Discounts and give aways on GOTA PICCEM Mushroom card game
After weeks of investigation, the Bozeman outbreak is contained, but the questions it raised are much harder to close. In the final episode of A Morel Dilemma, we return to Montana to understand how investigators traced the mushrooms, looked for additional cases, communicated risk to the public, and worked to prevent another outbreak. But the ending is not as simple as naming a culprit. Morels have now been linked to severe illness and death, yet we still do not know the toxin, why some people are more vulnerable, or exactly how much cooking is enough. Episode 7 brings the story back to what matters most: what we know, what we still do not know, and what has to happen next so this does not happen again. A Morel Dilemma Support the show Review the show where ever your listening Get Messages from Toxo (Join the Newsletter!) Join as a supporting member Ad free episodes Bonus content and early access Discounts and give aways on GOTA PICCEM Mushroom card game
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Hey everyone, it’s Ryan. I know many of you are patiently waiting for Episode 6 of A Morel Dilemma, and it is coming next week. I genuinely cannot wait for you to hear this one. But it is actually available right now for supporter members. You can go to www.thepoisonlab.com/support and get every single episode right now for as little as $1 a month. And full disclosure, I only get about half of that. It does not go to profit. It just helps repay some of the very real costs of making this show: the interviews, editing, sound design, hosting, and the absurd amount of time that went into producing it. So if you have been enjoying the series, becoming a supporter is an incredible way to help make work like this possible. And if you are already supporting the show, thank you. Truly. It helps more than you know. And for everyone else listening, thank you for being here and for sharing the series. But for today, I wanted to give everyone a small glimpse into the supporter bonus episodes that have been available to members throughout the series. See the episode here https://the-poison-lab.captivate.fm/episode/a-morel-dilemma-preview-supporting-member-bonus-episodes A Morel Dilemma Support the show Review the show where ever your listening Get Messages from Toxo (Join the Newsletter!) Join as a supporting member Ad free episodes Bonus content and early access Discounts and give aways on GOTA PICCEM Mushroom card game