The Holistic GLP-1 Podcast with Elizabeth McGann

Your Brain on GLP-1 s (with Dr. Sasha High)

The Holistic GLP-1 Podcast with Elizabeth McGann

Show Notes

You know what you *should* be doing to improve your health. So why can it feel almost impossible to follow through?

What if the problem isn't a lack of willpower, but the biology of your brain?

In this fascinating conversation, Elizabeth welcomes **Dr. Sasha High**, a board-certified obesity medicine physician, internist, and founder of High Metabolic Clinic and Best Weight, to explore how GLP-1 medications influence the brain, quiet food noise, reduce cravings, and create new opportunities for lasting behavior change.

Discover why old habits can be so difficult to break, how cognitive behavioral therapy (CBT) and mindfulness can help interrupt self-defeating thought patterns, and why self-compassion may be one of the most powerful tools for sustainable weight management.

They also explore the hormonal and metabolic changes of menopause, the science of appetite regulation, and a liberating new perspective on obesity as a chronic medical condition rather than a failure of personal discipline.

If you've spent years knowing what to do but struggling to do it, this episode could change the way you understand yourself.

FREE MICRODOSING MASTERCLASS: https://go.elizabethmcgann.com/masterclass

*** SHOW NOTES

(00:45) Why Knowing What to Do Isn't Enough (04:15) The Science Behind Your Brain's Autopilot (08:30) What GLP-1s Actually Do to Your Brain (12:45) Can GLP-1s Help You Rewire Your Brain? (17:00) How Long Does Lasting Habit Change Really Take? (21:00) CBT and ACT: Powerful Tools for Changing Your Behavior ( 25:45 ) Your Thoughts Aren't Always Facts: How to Break Negative Thinking Patterns (30:15) Breaking the Shame Cycle and Escaping the "Start Again Monday" Trap (34:30) Perimenopause, Menopause, and the Biology of Weight Gain (38:45) Obesity Is a Medical Condition, Not a Failure of Willpower (42:30) GLP-1s, Insulin Resistance, and the Brain: What's Really Driving Weight Loss? (46:30) The Future of Obesity Medicine: New Treatments and New Hope

*** Get Connected with Elizabeth McGann: FREE MICRODOSING MASTERCLASS: https://go.elizabethmcgann.com/masterclass Join our FREE SKOOL COMMUNITY - https://www.skool.com/holistic-glp-1-1163/about Instagram: http://www.instagram.com/elizabethmcgann Facebook: https://www.facebook.com/ElizabethMcGannWellness LinkedIn: https://www.linkedin.com/in/elizabethmcgann X/Twitter: https://twitter.com/ElizabethMcGann

*** Learn more about Dr. Sasha High: Website: https://www.sashahighmd.com/ Instagram: https://www.instagram.com/sashahighmd/?hl=en

More from The Holistic GLP-1 Podcast with Elizabeth McGann

Oct 6, 2026

You released the weight. You’re feeling healthier. Your confidence is coming back. So why do some of your relationships suddenly feel different? In this episode, Elizabeth explores something we don’t talk about enough: when you change, your relationships may need to change with you. A significant weight release can shift far more than your body. It can change how you see yourself, how you show up in the world, and the roles you’ve always played in your marriage, friendships, dating life and even professionally. Elizabeth shares her own experience of changing her relationship with food and alcohol, becoming healthier and more confident, and discovering that some of the relationships built around her old lifestyle no longer worked in quite the same way. She also talks about the uncomfortable “in-between”: when you’ve outgrown parts of your old life but haven’t fully built the new one yet, and what you can do to navigate that space while your new life takes shape. Sometimes relationships deepen. Sometimes they need to evolve. And sometimes you realize you’ve simply outgrown each other. The key is understanding that grieving and growing can happen at the same time, and the new life will continue to take shape.

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What if overeating, struggling to stick to your weight-loss goals, or bingeing, things you’ve spent years blaming yourself for, aren’t simply a lack of willpower?

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Your GLP-1 was working beautifully. The food noise got quieter. You started releasing weight. And then…the scale stopped moving. Does that mean your GLP-1 stopped working? Do you automatically need a higher dose? Not necessarily. In this episode, Elizabeth walks you through her 5-part Holistic GLP-1 Plateau Audit—the key areas to investigate before assuming the answer is more medication. You’ll learn how to look at your nutrition, blood sugar, metabolic health, gut, sleep and stress to better understand what your body may need. Elizabeth also shares what wearing a CGM for nearly a year taught her about her own metabolism—including the surprising impact stress had on her glucose.

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What if a GLP-1 could do more than help you lose weight?

Aug 11, 2026

FREE MASTERCLASS: How To Microdose A GLP-1 Holistically: https://go.elizabethmcgann.com/masterclass For years, women have asked me the same questions: What does it really mean to take a holistic approach to GLP-1s? Why am I so passionate about microdosing? And is it possible to naturally support the body's own GLP-1 production? In this special solo episode, I'm sharing the philosophy behind my work and introducing my new free masterclass, How to Microdose a GLP-1 Holistically. After years of working alongside physicians, studying the research, interviewing experts, and helping women achieve remarkable results, I've become convinced of one thing: this conversation is about much more than medication. It's about healing and ending your struggle with weight once and for all. You'll hear why I was initially skeptical of GLP-1s, what I learned from some of the earliest women using these medications, why I believe a truly holistic approach produces the best results, how to naturally support your body's own GLP-1 production, and why the ultimate goal isn't dependence, but helping the body remember what it already knows how to do. In This Episode You'll Learn: Why I was skeptical of GLP-1s when they first appeared What I learned from the earliest GLP-1 success stories The surprising truth about your body's natural ability to produce GLP-1 How to naturally stimulate your body's own GLP-1 production Why microdosing is only one piece of the puzzle How nutrition, sleep, movement, stress, and mindset influence your results Why I believe "less is more" The difference between using GLP-1s as a tool and becoming dependent on them Why lasting freedom is the true goal What you'll learn inside my new masterclass, How to Microdose a GLP-1 Holistically How to apply for a complimentary Holistic GLP-1 Microdosing Blueprint Call

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