The Integrative Health Podcast with Dr. Jen

Why Mast Cells Keep You Stuck in Fight or Flight

The Integrative Health Podcast with Dr. Jen

Show Notes

If you have mast cell symptoms and constantly feel stuck in fight or flight, the connection may be more physical than you realize. In Part 2 of this three-part solo series, Dr. Jen explains how mast cells and the nervous system communicate with each other, creating a feedback loop that can drive histamine release, anxiety, poor sleep, palpitations, hypervigilance, inflammation, and increased sensitivity to everyday triggers. She breaks down how stress signaling through CRH and the autonomic n...

More from The Integrative Health Podcast with Dr. Jen

Oct 20, 2026

Headlines about plague can trigger fear fast, especially when pneumonic plague and person-to-person transmission enter the conversation. In this solo episode, Dr. Jen takes a calmer look at Yersinia pestis, the bacterium responsible for plague, and breaks down the difference between bubonic and pneumonic disease, how quickly symptoms can develop, what warning signs deserve immediate medical attention, and why early antibiotic treatment matters. She also discusses immune resilience, gut health...

Oct 13, 2026

What happens when a physician believes the best option for a patient falls outside conventional standards of care? In this episode, Dr. Jen speaks with John Richardson about the legal and regulatory pressures facing integrative physicians, especially those using off-label therapies, personalized treatment plans, and approaches that do not fit neatly into insurance-driven medicine. John shares his experience working with physicians facing medical board investigations, regulatory scrutiny, lice...

Oct 6, 2026

Children today are facing more chronic health challenges than many pediatricians saw decades ago. In this episode, Dr. Jen sits down with pediatrician Dr. Robert Beckman to discuss what nearly 30 years of clinical practice have taught him about helping kids thrive. Dr. Beckman shares how his own son’s early developmental challenges pushed him to look beyond conventional pediatrics and begin studying nutrition, environmental exposures, immune health, and integrative medicine. They discuss the ...

Sep 29, 2026

Why do some women suddenly react to wine, leftovers, fermented foods, heat, supplements, or even medications they used to tolerate? In Part 3 of this solo mast cell series, Dr. Jen explains how shifting hormones in perimenopause can lower the threshold for histamine reactions and mast cell activation. She breaks down how estrogen may increase mast cell reactivity, why declining progesterone can reduce some of the body’s calming support, and how poor sleep, stress, cortisol, mold exposure, gut...

Sep 22, 2026

You do not have to work in a factory to accumulate heavy metals and environmental chemicals. In this episode, Dr. Jen sits down with integrative physician Dr. Megan Strauchman to discuss how mercury, arsenic, lead, nickel, glyphosate, and other environmental exposures may build up in the body over time and interfere with normal physiology. Dr. Strauchman explains where these exposures may come from, why heavy metals often accumulate in tissues rather than showing up clearly on a basic test, a...

See all episodes →