Hormones, Metabolism & You!

87: Stop Blaming Age – The Shocking Hidden Causes of Fatigue, Weight Gain, and Mood Swings with McCall McPherson and Dr. Tyna Moore

Hormones, Metabolism & You!

Show Notes

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What if the real answers to your midlife hormone struggles are not in a pill, but in understanding the deeper connections between your thyroid, metabolism, and the way your body changes over time?

In this powerhouse mashup episode, Dr. Cassie Smith brings together two of the most outspoken and experienced voices in functional medicine: McCall McPherson, thyroid expert and founder of Modern Thyroid Clinic, and Dr. Tyna Moore, a naturopathic physician and metabolic health disruptor. Together, they unpack the complex hormonal shifts women experience—especially during perimenopause and menopause—and share real-world strategies to reclaim health, energy, and vitality.

From GLP-1 medications to progesterone deficiency, thyroid misdiagnosis to strength training, this episode covers the most pressing questions women are asking today. You’ll hear personal insights, clinical wisdom, and evidence-based tools for navigating hormone changes, gut issues, inflammation, and mental health with clarity and confidence.

👤 About the Guests

McCall McPherson is the founder of Modern Thyroid Clinic and Thyroid Nation, a TEDx speaker, physician assistant, and a thyroid warrior herself. Her mission is to end the suffering of millions with thyroid disorders through expert care, patient advocacy, and empowering education.

Dr. Tyna Moore is a licensed Naturopathic Physician and Chiropractor specializing in resilient metabolic health, regenerative medicine, and clinical strength training. She's also the host of The Dr. Tyna Show and a strong advocate for women’s health and muscle-centric aging.

🔑 Key Topics Covered

✅ The truth about GLP-1s like semaglutide and tirzepatide—and what microdosing really means

✅ When to consider hormone therapy and why most women need progesterone earlier than expected

✅ Why muscle is your best metabolic and hormone-supporting organ

✅ The thyroid–estrogen connection and how hormone shifts during menopause impact thyroid function

✅ How GLP-1s can expose hidden dysfunctions like gut dysbiosis and low estrogen

✅ Why low progesterone may be behind your irritability, sleep issues, and anxiety

✅ The importance of comprehensive thyroid testing (FT3, FT4, RT3) and individualized care

✅ Gut–hormone–brain axis: how estrogen and thyroid hormones influence mood and digestion

✅ Alcohol and inflammation: the honest truth about even “just one glass”

✅ Empowering women to advocate for their health in a broken system

✅ The generational shift in how women approach midlife and aging

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Dr. Anna Cabeca joins me to talk about why so many midlife women are told their labs are normal while they feel exhausted, foggy, and out of step with their own bodies. We talk about what shifts in perimenopause, how falling progesterone and insulin resistance can show up as everyday symptoms, and why Dr. Cabeca treats hormone imbalance as a metabolic question first.

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