Immunotherapeutics including Check Point InhibitionDiaeventontologics of Cancer Therapy VI Authentic Biochemistry Podcast Dr. Daniel J Guerra 23Oct26

Dr. Daniel Jaguar presents a comprehensive lecture on immunotherapeutics, focusing on the metabolic pathways involved in T cell activation and their implications for cancer therapy. He emphasizes the dynamic nature of metabolic pathways, arguing against the notion of fixed biochemical processes. Instead, he describes a state of constant flux where various biochemical sequences are intricately regulated to maintain cellular functions, particularly in T cells.

The discussion highlights the role of the mTOR pathway in T cell metabolism, detailing how mTOR complexes I and II regulate essential processes such as glycolysis and lipid biosynthesis. Raptor and Richtor, key proteins in these complexes, are shown to be critical for T cell activation and metabolic programming. The lecture also explores how AMP kinase serves as a rheostat for energy homeostasis, influencing T cell function and proliferation in response to metabolic stress, particularly in tumor microenvironments where oxygen levels are low.

Jaguar further connects these metabolic processes to cancer biology, explaining how tumor cells exploit similar pathways to thrive under hypoxic conditions. He underscores the importance of understanding these metabolic interactions, as they can inform therapeutic strategies aimed at enhancing T cell efficacy against tumors. The lecture concludes with a call for deeper insights into the metabolic dysregulation that occurs in cancer, which can hinder immune responses and promote tumor progression.

References Front Cell Dev Biol. 2018 Sep 25;6:122. Int J of Oncology 2021. January V.58.Issue 1 :9-19. FASEB J. 2025. April 30. Volume39, Issue8 e70520 Guerra, DJ.2026.Unpublished Lectures. Bach, JS. 1720.Concerto 2 Violins in D.BMV 1043. https://music.youtube.com/playlist?list=OLAK5uy_n7DB_n3FtKwhYg1hfcxb6fdR5h1VBFSRw&si=3u-N57UfMup_4N0t