Episode 498: Do You Want a One and Done Cholesterol Infusion? The Long Road Ahead
Heart Doc VIP with Dr. Joel KahnShow Notes
Dr. Joel Kahn dives into a groundbreaking Phase 1 trial of Verve 102, a one-time intravenous gene-editing treatment that silences the PCSK9 gene to produce lasting LDL cholesterol reduction. Among 35 participants, the high-dose group saw LDL drop by 62% with mostly mild side effects — promising results, though Phase 2 and 3 trials and 15 years of follow-up still lie ahead.
Also covered: updated colorectal cancer screening guidelines now starting at age 45, healthy lifestyle habits cutting mortality risk in cancer survivors by one-third, real-world weight regain data after stopping GLP-1 medications, why your B12 "normal" range may be too low, a blood test that may predict Alzheimer's years in advance, and a longevity preparedness tool from MIT AgeLab.
Sponsored by Igennus — visit igennus.com/drkahn for 20% off.
More from Heart Doc VIP with Dr. Joel Kahn
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This week, Dr. Kahn presents the case of a patient seen this month at the Kahn Center for Cardiac Longevity who, over the course of five years, has reversed artery aging and plaque and is enjoying excellent health. He discusses the program used to achieve these benefits. This case, along with many others from the Kahn Center, offers hope for maintaining youthful arteries throughout your life.
This week, Dr. Kahn presents a new scientific statement by the American College of Cardiology on nutrition to prevent heart disease. The emphasis is on plant-based choices while limiting red meat, processed foods, and excess added sugar. Sometimes, hearing the same recommendation over and over can help.
This week, as a bonus, Dr. Kahn interviews a Detroit clothing legend, Phil, who celebrated his 100th birthday recently by buying a new sports car! He is approaching his 78th wedding anniversary with his beautiful wife. He discussed his early days in business and early successes, and his health journey, relying a lot on the education he got by repeatedly visiting the Pritikin Longevity Center.
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