Conférence - Arnold Kriegstein: Genomic Insights into Human Brain Development, Evolution, and Disease

Jean-Jacques Hublin Chaire Paléoanthropologie Collège de France Année 2026-2027

Insights into the Development, Evolution, and Diseases of the Human Neocortex Conférence - Arnold Kriegstein: Genomic Insights into Human Brain Development, Evolution, and Disease

Arnold Kriegstein Professeur de neurologie, université de Californie, San Francisco

Résumé

The development of the human neocortex is highly dynamic, involving complex cellular trajectories controlled by gene regulation. We collected paired single-nucleus chromatin accessibility and transcriptome data from multiple regions and age groups of the developing human neocortex. In addition, spatial transcriptomic analysis was utilized to reveal cellular niches and cell-cell communication. These datasets revealed molecular and cellular dynamics in cell composition, spatial organization, intercellular signaling, gene regulation, lineage potential, and disease susceptibility. The atlas identifies novel progenitor lineages, provides insights into glioblastoma and neuropsychiatric disorders, and offers a roadmap for deriving specific neural cell types from pluripotent stem cells.