Show Notes
Welcome Back Rheumatology Fans, 2026… The year of the GLP-1 Agonist? Video Summary In this video, Jack, The Rheumatology Physio, discusses the rapidly growing interest in GLP-1 agonists (such as Ozempic) and their potential role in rheumatology and inflammatory arthritis. I reflect on the increasing public and clinical attention these medications are receiving, particularly as many people report improvements in chronic inflammatory and autoimmune conditions alongside significant weight loss. GLP-1 agonists mimic the body’s natural GLP-1 hormone, helping regulate blood sugar, suppress appetite, and promote weight loss. The key rheumatology question, however, is why some people with conditions such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and osteoarthritis are reporting symptom improvements while taking them. There are two likely mechanisms. First, excess abdominal fat is immunologically active and raises the body’s baseline level of inflammation, which worsens arthritis symptoms and disease activity. By reducing this fat, GLP-1 drugs may lower systemic inflammation, creating an anti-inflammatory shift. Second, emerging evidence suggests these drugs may also directly interact with inflammatory and immune pathways involved in autoimmune disease — meaning their benefits may go beyond weight loss alone. However, at present, GLP-1 agonists are not formally prescribed specifically to treat arthritis. They are currently used for weight management, with any improvement in arthritis considered a secondary benefit. His practical advice is for people with inflammatory arthritis and excess body fat to discuss GLP-1 therapy with their GP or rheumatologist as part of a broader medical plan. He predicts that dedicated rheumatology use of GLP-1 drugs is likely to arrive in the near future as evidence grows.
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Welcome Back Rheumatology Fans, Ooof this is going to rattle some cages. Synopsis below but the best of this is watching the video. A recent news report about a woman with rheumatoid arthritis who was convicted of benefit fraud caught my attention. The case involved footage of her participating in activities including gym classes and running events despite having previously reported substantial limitations in her day-to-day function. I don’t know enough about the individual circumstances to comment on whether the judgement was appropriate. In fact, the reported offence appears to relate specifically to failing to notify the Department for Work and Pensions of a change in circumstances. But the story raises a broader issue that is highly relevant to people living with inflammatory arthritis and the clinicians treating them. Being physically active does not necessarily mean someone is not disabled. Rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis and other long-term inflammatory diseases can be enormously variable. Symptoms may fluctuate over time, treatments can substantially improve function, and limitations in one activity do not necessarily predict someone’s ability to perform another. Exercise also forms an important part of rehabilitation. I might see someone who currently cannot run, play tennis or golf because their inflammatory arthritis is poorly controlled. Following improvements in medication and a structured rehabilitation programme, one of our explicit treatment goals might be to return them to those activities. For another person, the goal might simply be getting upstairs more comfortably. To achieve that, we may use relatively demanding strengthening exercises in a gym. Seeing that person performing a squat or leg press tells you very little, in isolation, about how easily they can negotiate their stairs later that day. That distinction matters. We should not create an environment where people receiving appropriate financial support become frightened of exercising because they worry that being seen in a gym, lifting weights or participating in sport could somehow be interpreted as evidence that they are no longer disabled. From a clinical perspective, I want people with inflammatory arthritis to be as active as their condition, preferences and circumstances allow. Where possible, that includes meeting general physical activity recommendations and incorporating cardiovascular and resistance exercise. There are good reasons for doing so. Maintaining physical activity can help protect muscle and bone, improve cardiovascular health and support broader long-term health outcomes. For some patients, returning to demanding exercise is itself a major marker of successful treatment. None of this means that changes in someone’s circumstances should not be reported where required. That is a separate issue. The important point is that exercise capacity and disability are not opposites. A person can exercise and still experience meaningful restrictions from inflammatory disease. They can also improve dramatically with treatment while continuing to have limitations elsewhere. As clinicians, we should be encouraging people towards greater function—not inadvertently giving them another reason to be afraid of achieving it.
This is a free preview of a paid episode. To hear more, visit rheumatologyphysio.substack.com
This is a free preview of a paid episode. To hear more, visit rheumatologyphysio.substack.com