Show Notes
“It’s pronounced nuc-ul-ophosmin” “Nucleophosmin”. “Noo-clee-o-phosmin”. FLT3-ITD got you In The Dumps? Have a Total Knowledge Deficit about TKD mutations? Struggling with the A-B-Cs of NPM1 mutations? Want to know how a cat sarcoma is somehow related to AML? Join the Bloody Minded Crew as they flit about the laboratory looking at the structure of FLT3 and NPM1, what these proteins usually do and how we test for mutations in the advanced myeloid episode. == Edit 6/5/26 = We've been made aware...
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Look! It’s a follicular lymphoma! No wait, it’s a DLBCL! No wait, it’s a CLL? Actually is it a leukaemia? Join Nick, Cale and Bashar as they wrestle with the morphological and prognostic chameleon that is Mantle Cell Lymphoma. With all the bad bits of an indolent lymphoma and all the bad bits of an aggressive one – as Michael Jackson would say, it's bad (really, really bad). Except when it isn't. Who knows what mantle is doing – we don't think it knows itself TIMESTAMPS 0:57 - Conspiracies 10...
What do you call a small B-cell lymphoma that isn't CD5 positive, isn't CD10 positive and generally refuses to wear any of the usual hats? Probably marginal zone lymphoma. Possibly. Maybe. Join the Bloody Minded crew as we head to the edge of the follicle where the bloodstream's customs officers live, and look at what happens when they go rogue. Discover how to cure a cancer with a PPI, and why we're so very bored of the NF-κB pathway. TIMESTAMPS 0:57 - Whisky sponsorship pls and thx 2:11 - W...
Join the boys as they frollickular through the molecular and macro-cular particulars of follicular lymphoma this week. While you're at it, please sign our petition to allow Bashar back into the aquarium and take a gander at Cale's tiny hands. Timestamps 00:52 - Bashar is banned from the Aquarium a second time 02:13 - Follicular Lymphoma Overview 06:07 - Pathophysiology of FL 09:50 - Follicular Lymphoma In Situ (Old Name) 11:54 - Clinical & Morphology 17:24 - Identifying FL in the Lab 20:0...
Why do haematologists get excited over smudges on a film? What is the deal with that whole IGHV situation? Why is Bashar no longer welcome at the zoo? Join us as we find the answers to these common haematology questions and more in a foray into Chronic Lymphocytic Leukaemia! TIMESTAMPS 0:55 - No animals were harmed in the making of this bit 4:13 - Epidemiology of CLL 5:56 - Pathophysiology of CLL 11:42 - MBL 12:36 - SLL 15:54 - Clinical features of CLL 18:1...
Welcome to the Land of the Lymphoid. Eighty-odd subtypes, one grid. Help us break our cellular pathways and journey further into our lymphoid season as we ask the only two questions that matter - B or T, fast or slow, forget the platypuses - and build the framework we'll be filling in for the rest of the series. Bring a hat, the savannah is hot. 0:52 - Lymphoid Planet 2:50 - Leukaemia vs Lymphoma 4:51 - Two Questions & A Recap 8:49 - Identifying a Cell 16:22 - Indolent vs Aggressive...