Show Notes
#Peptides #PeptideTherapy #GLP1 #AntiAgingMedicine #bpc157 Peptides didn't start with a wellness influencer — they started with a dying 14-year-old boy in 1922 and a shot of insulin. Today that same category includes everything from FDA-approved medications to unregulated research chemicals sold online with zero oversight. In this video I break down over 20 peptides — from BPC-157 and TB-500 to semaglutide, tirzepatide, retatrutide, and the newest FDA regulatory update on compounding access — organized into the three levels of biology they actually work on: cellular energy, tissue repair, and systemic control (your hormones, metabolism, and nervous system). 🎓 Complete GLP-1 Weight Loss Masterclass — Lifetime Access Comprehensive education on GLP-1 medications, nutrition, exercise, muscle preservation, side effects & long-term success. Includes the companion eBook, quizzes, 12-week exercise program, certificate & future course updates at no additional cost. https://www.drmohammedpaika.com 📩 FREE GLP-1 Diet Cookbook + Weekly Newsletter Get weekly evidence-based insights on GLP-1s, metabolic health, nutrition, exercise & longevity. https://www.drmohammedpaika.com/newsletter 📚 The Weight Equation & The Physician’s Physique Physician-written, evidence-based guides to obesity, weight loss, nutrition, metabolism, exercise, body composition & healthier living. https://www.drmohammedpaika.com/books 👥 Metabolic Health Community https://www.skool.com/metabolic-health-community-5316
TIMESTAMPS 0:00 – Intro — why peptides aren't what you think 1:21 – What a peptide actually is 3:24 – Why "your body recognizes it" doesn't mean it's right for you 5:15 – The three-layer framework 6:18 – Layer One: Cellular energy (Epitalon, MOTS-c, SS-31) 11:58 – Layer Two: Tissue repair (BPC-157, TB-500, GHK-Cu) 18:08 – Layer Three: Hormones (Sermorelin, Ipamorelin, CJC-1295, Tesamorelin) 21:36 – Layer Three: Metabolism (Semaglutide, Tirzepatide, Retatrutide) 26:24 – Layer Three: Brain & nervous system (Semax, Selank, Dihexa, Cerebrolysin) 31:40 – The most expensive mistake I see 33:44 – What to do with this References WHO — Diabetes Fact Sheet: ~9 million people worldwide live with type 1 diabetes and require insulin injections for survival National Institute on Aging — "Exendin-4: From Lizard to Laboratory...and Beyond" PubMed — "The Development of Byetta (Exenatide) From the Venom of the Gila Monster" (PMID 21194543) Cell Metabolism (2015) — "The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance" Khavinson, Bondarev, Butyugov — "Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells," Bulletin of Experimental Biology and Medicine, 2003 Khavinson et al. — "Effect of Epitalon on Biomarkers of Aging, Life Span and Spontaneous Tumor Incidence in Female Swiss-Derived SHR Mice," Bulletin of Experimental Biology and Medicine Johns Hopkins ICTR; Pharmacy Times; Drugs.com — FDA accelerated approval of Forzinity (elamipretide/SS-31) for Barth syndrome, September 19, 2025 Genetics in Medicine — Phase 2/3 randomized trial of elamipretide (SS-31) in Barth syndrome (PMC7935714) Pickart et al. — "Regenerative and Protective Actions of the GHK-Cu Peptide in the Skin and Other Tissues" (PMC6073405) USADA — Athlete Advisory on 2022 WADA Prohibited List changes (BPC-157) Sport Integrity Australia — Thymosin Beta-4 (TB-500) substance profile Pharmaceutical Executive — "FDA Votes to Loosen Restrictions for Four Peptides" (July 23, 2026); STAT News coverage of the same PCAC vote (BPC-157 8-6, TB-500 8-6, KPV 8-6, MOTS-c 7-5 — advisory only, formal rulemaking still pending) CBS News — "Stallone Pleads Guilty to Import Charge" / "Australia Fines Sly for Toting Hormones" (2007); Hollywood Reporter (2007); Taipei Times wire report (May 22, 2007) FDA — Approved labeling for EGRIFTA (tesamorelin for injection) Jastreboff et al., New England Journal of Medicine, 2023 — Phase 2 trial o
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#Testosterone #TRT #LowTestosterone #GLP1 #weightloss Is “male menopause” real, and do you actually need testosterone therapy? As an internal medicine and obesity medicine physician, I break down what the research really shows about low testosterone after 50, including: How common true late-onset hypogonadism actually is (hint: far less than the ads suggest) Why excess weight is the #1 fixable cause of low testosterone, and how GLP-1s like Ozempic and Mounjaro may help your own testosterone come back How to get tested properly (morning, fasting, repeated) What TRT can and can’t do, according to the Testosterone Trials What the TRAVERSE trial showed about heart safety, plus the side effects that did go up The newest FDA label changes and the HHS proposal A simple 5-question checklist to work through with your doctor before you ever start TRT 📘 FREE GLP-1 Diet Cookbook (high-protein meals for a smaller appetite): https://drmohammedpaika.com/newsletter 🎓 GLP-1 Masterclass (calorie and protein targets, side effects, and a 12-week home strength program): https://drmohammedpaika.com This video is for educational purposes only and is not medical advice. Talk to your own doctor before starting, stopping, or changing any medication. TIMESTAMPS 0:00 Is low testosterone really the answer? 1:34 Is “male menopause” even real? 3:13 The biggest driver of low testosterone: weight 4:04 How GLP-1s may raise your own testosterone 5:00 The other side: semaglutide and low T 6:03 How to know if you actually have low testosterone 7:28 What TRT really does: the Testosterone Trials 8:54 Is testosterone safe for your heart? (TRAVERSE) 10:29 FDA label changes and the HHS proposal 11:04 On a GLP-1 and testosterone at the same time? 12:06 Should everyone consider hormone therapy? 13:08 5 questions to ask before starting TRT 14:24 What to watch next 📚 REFERENCES Gray A, et al. Massachusetts Male Aging Study. J Clin Epidemiol. 1991;44:671-684. Feldman HA, et al. Massachusetts Male Aging Study. J Clin Endocrinol Metab. 2002;87:589-598. Wu FCW, et al. European Male Ageing Study: late-onset hypogonadism. N Engl J Med. 2010;363:123-135. Corona G, et al. Weight loss and obesity-associated hypogonadism (meta-analysis). Eur J Endocrinol. 2013;168:829-843. Portillo-Canales S, Dhindsa S, et al. Incretin-based drugs and testosterone in men. ENDO 2025 abstract RF27-03; Endocr Pract. 2026;32:696-703. Liao B, Able C, et al. Semaglutide and hypogonadism/ED in non-diabetic men. SMSNA 2023 abstract 157; Able C, et al. Int J Impot Res. 2024. Bhasin S, et al. Testosterone therapy in men with hypogonadism: Endocrine Society guideline. J Clin Endocrinol Metab. 2018;103:1715-1744. Mulhall JP, et al. Evaluation and management of testosterone deficiency: AUA guideline. J Urol. 2018;200:423-432. Snyder PJ, et al. Effects of testosterone treatment in older men (Testosterone Trials). N Engl J Med. 2016;374:611-624. Qaseem A, et al. Testosterone treatment in men with age-related low testosterone: ACP guideline. Ann Intern Med. 2020;172:126-133. Lincoff AM, et al. Cardiovascular safety of testosterone-replacement therapy (TRAVERSE). N Engl J Med. 2023;389:107-117. Snyder PJ, et al. Testosterone treatment and fractures in men with hypogonadism. N Engl J Med. 2024;390:203-211. U.S. FDA. Class-wide labeling changes for testosterone products. Feb 28, 2025. U.S. HHS. Request to update testosterone replacement therapy labeling. June 18, 2026 (proposed). U.S. FDA. Removal of boxed warnings on menopausal hormone therapy. Nov 2025. Wilding JPH, et al. STEP 1. N Engl J Med. 2021;384:989-1002. Jastreboff AM, et al. SURMOUNT-1. N Engl J Med. 2022;387:205-216.
#GLP1 #Microdosing #Zepbound #Ozempic #WeightLossMaintenance Microdosing Zepbound & Ozempic: How Low Can You Go and Still Keep the Weight Off? You hit your goal weight. Now the question is: do you have to stay on this dose forever? More and more people are cutting their GLP-1 dose to a fraction or stretching their shots to every 10 to 14 days, hoping to save money, cut side effects, and keep the weight off. I'm Dr. Mohammed Paika, a board-certified internal medicine and obesity medicine physician and practicing hospitalist. In this video I break down what the research actually shows about lower-dose GLP-1 maintenance, and what it doesn't show yet.
#Ozempic #Mounjaro #GLP1 #Tirzepatide #WeightLossDoctor Should you split your weekly Ozempic, Wegovy, Mounjaro, or Zepbound shot into two smaller doses? Lots of you have asked me about this in the comments. People split their dose to ease the nausea in the first few days and keep food noise down late in the week. In this video, I explain what the pharmacokinetics predict, what the clinical trials did and didn’t test, and the hidden risks most people never hear about. As an obesity medicine physician, I walk you through half-life, steady state, peak and trough levels, and a simple model of what splitting does to your drug levels. Then I cover the safer, approved ways your doctor can smooth out your week instead. 📩 FREE GLP-1 Diet Cookbook + Weekly Newsletter Get weekly evidence-based insights on GLP-1s, metabolic health, nutrition, exercise & longevity. https://www.drmohammedpaika.com/newsletter
#FoodNoise #GLP1 #Ozempic #WeightLoss #ObesityMedicine Can't stop thinking about food, even right after a full meal? That constant chatter has a name: food noise. I explain what it is, why GLP-1 medications like Ozempic, Wegovy, Mounjaro and Zepbound quiet it, and why it often returns when people stop them. You'll learn the 2 drivers behind it, a simple test to tell real hunger from food noise, and 9 evidence-based strategies to turn it down, with or without medication. Every claim is referenced below. 📩 FREE GLP-1 Diet Cookbook + Weekly Newsletter Get weekly evidence-based insights on GLP-1s, metabolic health, nutrition, exercise & longevity. https://www.drmohammedpaika.com/newsletter 🎓 Complete GLP-1 Weight Loss Masterclass — Lifetime Access Comprehensive education on GLP-1 medications, nutrition, exercise, muscle preservation, side effects & long-term success. Includes the companion eBook, quizzes, 12-week exercise program, certificate & future course updates at no additional cost. https://www.drmohammedpaika.com
#GLP1 #Menopause #Tirzepatide #Semaglutide #WeightLoss Not losing weight on a GLP-1 after menopause? You’re not imagining it, but your body isn’t broken and the medication hasn’t stopped working. In this video, I’m Dr. Mohammed Paika, board-certified in internal medicine and obesity medicine. I break down what the research really shows about GLP-1s like tirzepatide (Mounjaro, Zepbound) and semaglutide (Ozempic, Wegovy) after menopause. You’ll learn what menopause does to fat, muscle and metabolism, and how much weight women actually lose at each stage of menopause in the clinical trials. I’ll show you why real-world results can lag, what the newest hormone therapy studies show and why they don’t prove cause and effect, and how to protect your muscle and bones. I’ll also walk you through the 5-step plan I use with my midlife patients. 📩 FREE GLP-1 Diet Cookbook + Weekly Newsletter https://www.drmohammedpaika.com/newsletter 🎓 Complete GLP-1 Weight Loss Masterclass — Lifetime Access Comprehensive education on GLP-1 medications, nutrition, exercise, muscle preservation, side effects & long-term success. Includes the companion eBook, quizzes, 12-week exercise program, certificate & future course updates at no additional cost. https://www.drmohammedpaika.com TIMESTAMPS 0:00 Why weight loss feels harder after menopause 1:56 What menopause does to your body 4:15 Do GLP-1s still work after menopause? 7:12 Why it feels harder in real life 9:06 Hormone therapy and GLP-1s: what the data shows 11:21 Free GLP-1 Diet Cookbook 11:44 Protecting your muscle and bones 13:42 GLP-1 Masterclass 14:12 The 5-step midlife GLP-1 plan 15:35 A real viewer example 16:41 Final thoughts 📚 REFERENCES Greendale GA, et al. Changes in body composition and weight during the menopause transition (SWAN). JCI Insight. 2019;4(5):e124865. Lovejoy JC, et al. Increased visceral fat and decreased energy expenditure during the menopausal transition. Int J Obes. 2008;32(6):949-958. Pontzer H, et al. Daily energy expenditure through the human life course. Science. 2021;373(6556):808-812. Karppinen JE, et al. Age but not menopausal status is linked to lower resting energy expenditure. J Clin Endocrinol Metab. 2023;108(11):2789-2797. Thomson ZO, et al. Weight loss outcomes in premenopausal versus postmenopausal women during behavioral weight loss interventions. Menopause. 2021;28(3):337-346. Tchang BG, et al. Body weight reduction in women treated with tirzepatide by reproductive stage (SURMOUNT post hoc). Obesity. 2025;33:851-860. García-Pérez LE, et al. Tirzepatide weight reduction by sex: SURMOUNT-1 to -4 post hoc. Presented at EASD 2024. Castaneda R, et al. Sex, not age, predicts weight loss outcomes with tirzepatide. Obesity. 2026;34(Suppl 2):132-145. Huvinen E, et al. Body weight loss with semaglutide 7.2 mg is independent of menopausal status (STEP UP post hoc). Presented at the European Congress on Obesity, 2026. Castaneda R, et al. Impact of reproductive stage and menopausal hormone therapy on weight loss outcomes with tirzepatide. Presented at The Menopause Society Annual Meeting, 2025. Nedeltcheva AV, et al. Insufficient sleep undermines dietary efforts to reduce adiposity. Ann Intern Med. 2010;153(7):435-441. Hurtado MD, et al. Weight loss response to semaglutide in postmenopausal women with and without hormone therapy use. Menopause. 2024;31:266. Castaneda R, et al. Menopause hormone therapy and tirzepatide-associated weight loss in postmenopausal women. Lancet Obstet Gynaecol Womens Health. 2026;2(2):e118-e128. Hurtado MD, et al. Semaglutide reduces body weight regardless of menopause status (STEP and OASIS 4 post hoc). Presented at ObesityWeek, 2025. Papadakis GE, et al. Menopausal hormone therapy is associated with reduced total and visceral adiposity (OsteoLaus). J Clin Endocrinol Metab. 2018;103(5):1948-1957. Wilding JPH, et al. Once-weekly semaglutide in adults with overweight or obesity (STEP 1). N Engl J Med. 2021;384(11):989-1002. Look M, et al. Body c