The Skeptics Guide to Emergency Medicine

SGEM#524: High, High HOPE for Recovery – Alteplase between 4.5 and 24 hours

The Skeptics Guide to Emergency Medicine

Show Notes

Date: October 6, 2026 Guest Skeptic: Dr. Ryan Stanton, creator of the EM podcast Front Line and the new President of the American College of Emergency Physicians (ACEP). Reference: Zhou et al. HOPE investigators. Alteplase for Acute Ischemic Stroke at 4.5 to 24 Hours: The HOPE Randomized Clinical Trial. JAMA. 2025 Case: Mr. Wei Zhang […]

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