The Gut-Brain Paradox: Secrets To Restoring Health - with Steven Gundry | EP 199
The Empowering Neurologist PodcastShow Notes
🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 Welcome back to The Empowering Neurologist! In this episode we have a truly fascinating conversation lined up with none other than Dr. Steven Gundry, a world-renowned heart surgeon-turned-functional medicine expert, whose work has transformed the way we understand diet, disease, and longevity. Dr. Gundry is no stranger to challenging conventional medical wisdom. In his latest book, The Gut-Brain Paradox: Improve Your Mood, Clear Brain Fog, and Reverse Disease by Healing Your Microbiome (HarperCollins; April 15, 2025), he flips the script on the traditional gut-brain connection. His research reveals a startling truth: your microbiome is not just influencing your brain—it’s controlling it. For years, we’ve heard that the brain sends signals to the gut. But Dr. Gundry shows that it’s actually the other way around: the microbes in our gut are shaping our thoughts, emotions, and even personality. From food cravings to mental health struggles, from cognitive decline to addiction—these tiny gut-dwelling organisms are the real puppet masters. And when our gut falls out of balance, neurological dysfunction follows. In this episode, we’ll explore: ✅ How gut bacteria influence cravings, mood, and even personality ✅ The surprising link between gut inflammation and drug tolerance ✅ Why a leaky gut can lead to brain fog, neurodegeneration, and mental health issues ✅ How to reclaim control of your mind by healing your microbiome Dr. Gundry lays out a powerful, science-backed plan to restore gut health and optimize brain function, mental clarity, and emotional well-being. If you’ve ever struggled with brain fog, anxiety, depression, or unexplained neurological symptoms, this episode is a must-listen. Tune in to this eye-opening conversation and discover how fixing your gut provides an important step to unlocking your brain’s full potential. ====
00:00 Introduction 03:00 Why a Heart Surgeon Wrote a Book on the Brain 06:18 The Forgotten Hero Who Was Beaten to Death for Washing His Hands 09:08 A Parkinson’s Case Reversed by Healing the Gut? 13:28 Gluten Cross-Contamination and a Son’s Cutting Board: A Shocking Relapse 19:16 Gut Leaks, Brain Barriers, and Immune Sabotage: The Mechanism Explained 23:15 The Alzheimer’s Barrier Theory: Why Beta-Amyloid Might Be the Brain’s Defense System 26:20 Can Depression Be Healed Through the Gut? 30:27 Are Bacteria Controlling Your Addictions and Cravings? 34:02 The Scariest Mind-Control Parasite You’ve Never Heard Of 38:41 Eat This, Not That: How to Hack Your Gut for Better Brain Health 41:23 Neu5Gc and How it Impacts Our Brains 48:03 Are Polyphenols the Brain’s Secret Weapon? 56:38 Dead Bacteria, Live Benefits: Why Your Probiotic Doesn’t Need to Survive 01:05:05 Conclusion and Thank you ==== Steven R. Gundry, MD, is the director of the International Heart and Lung Institute in Palm Springs, California, and the founder and director of the Center for Restorative Medicine in Palm Springs and Santa Barbara. After a distinguished surgical career as a professor and chairman of cardiothoracic surgery at Loma Linda University, Dr. Gundry changed his focus to curing modern diseases via dietary changes. He has written more than three hundred articles published in peer-reviewed journals on using diet and supplements to eliminate heart disease, diabetes, autoimmune disease, and multiple other diseases. He is the host of the top ranked nutrition podcast The Dr. Gundry Podcast and founder of Gundry MD, a wellness brand. Dr. Gundry lives with his wife, Penny, and their dogs in Palm Springs and Montecito, California. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1
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🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter's newsletter at: https://www.drperlmutter.com Sponsors & Special Offers EVY – Go to https://www.optoceutics.com/perlmutter to get 10% off & free shipping (90 days risk-free). Memory Air – Go to https://www.memoryair.com and use code PERLMUTTER for 15% off, free shipping and a 60-day money back guarantee. Brain Defenders – Dr. Perlmutter's groundbreaking new book is now available! Discover how to protect your brain and future health: https://www.braindefenders.com About This Episode You can be successful, respected, and highly productive while still feeling invisible. In this episode of The Empowering Neurologist, Dr. David Perlmutter sits down with John R. Miles, bestselling author, behavioral change expert, and host of Passion Struck, to explore why achievement, recognition, and external success do not always create a lasting sense of self-worth. Drawing from his childhood brain injury, military service, and executive career, John explains the concept of human mattering: the fundamental need to feel seen, valued, and significant. They discuss the “mattering gap,” the “slow fade” that can happen when people become disconnected from themselves, and why belonging and mattering are not the same. John also introduces the MATTER framework, built around six conditions that help people feel valued and connected: meaning, autonomy, trust, time, energy, and reciprocity. They explore how parents, leaders, physicians, and communities can help others feel that they matter, and why separating personal worth from productivity and external approval can lead to more meaningful relationships and intentional living. You can continue pursuing success without making it the measure of your worth. Your value is not something you have to earn. Timestamps 00:00 – John Miles’ Childhood Brain Injury and Defining Moment 06:16 – What It Means to Matter vs. Belong 07:32 – The Slow Fade: When Success Makes You Feel Invisible 14:43 – Understanding the Mattering Gap 19:34 – Why Children Need to Feel Seen and Valued 27:20 – The MATTER Framework: Six Conditions for Feeling Valued 31:13 – Why Patients Need to Be Seen Beyond Their Diagnosis 36:11 – Creating a Workplace Where Employees Feel Valued 44:31 – Why Your Worth Is Already a Completed Fact 48:32 – The Difference Between Proving Yourself and Accomplishing Goals About John R. Miles John R. Miles is a bestselling author, keynote speaker, behavioral change expert, and host of the award-winning, top-ranked podcast Passion Struck®. A former U.S. Navy officer and Fortune 50 C-suite executive, John combines military discipline, corporate strategy, neuroscience, and psychology to help people and organizations reduce isolation, strengthen self-worth, and live with greater intention. He is the author of Passion Struck and The Mattering Effect. His work explores how people can separate their inherent worth from external achievement, build deeper relationships, and create a meaningful impact without losing themselves in the process. Through his books, podcast, speaking, and global community, John leads a growing movement centered on one essential message: every person deserves to feel seen, valued, and significant. Connect with John Website: https://johnrmiles.com Instagram: https://www.instagram.com/john_r_miles LinkedIn: https://www.linkedin.com/in/johnmileshumanperformanceexpert Facebook: https://www.facebook.com/johnrmiles.c0m Podcast: https://passionstruck.com/passion-struck-podcast Connect with Dr. Perlmutter Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ This podcast is produced by DrTalks.com http://drtalks.com/channel-growth
🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter's newsletter at: www.drperlmutter.com. ✉️ 🌱 EVY - Go to https://www.optoceutics.com/perlmutter to get 10% off & free shipping (90 days risk-free). Memory Air - Go to www.memoryair.com and use code PERLMUTTER for 15% off, free shipping and a 60-day money back guarantee. ==== Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available! Discover how to protect your brain and future health - grab your copy today at https:/www.braindefenders.com. ==== Your food contains far more than protein, carbohydrates, fat, vitamins, and minerals. Researchers have identified more than 100,000 molecules in food, and most of them never appear on a nutrition label. In this episode of The Empowering Neurologist, Dr. David Perlmutter sits down with his son, Dr. Austin Perlmutter, to explore the "dark matter" of nutrition: thousands of plant compounds called polyphenols. They discuss how these nutrients may influence the gut microbiome, the immune system, inflammation, blood flow, metabolism, and gene expression, and what high-polyphenol diets may mean for memory and the aging brain. Dr. Austin also shares his research on Himalayan Tartary buckwheat and what an early study suggests about epigenetics, cognition, and healthy aging. He offers practical ways to find more polyphenols in everyday foods like coffee, tea, dark chocolate, berries, legumes, and extra virgin olive oil, plus simple tips for identifying better options at the grocery store. You don't need an expensive supplement plan to begin. Adding more natural colors and bitter flavors to your plate can be a meaningful first step. https://bttcorp.com/contact/ for inquiries about Dr. Abreu's work. 00:00 — Cold Open: Why Food Matters for Brain Health 00:55 — What Are Polyphenols, and Why Do They Matter? 02:15 — Food as a Predictor of Long-Term Brain Health 04:23 — The “Dark Matter” Hidden in Our Food 08:04 — Why Have These Nutrients Been Overlooked? 11:06 — What Polyphenols Actually Do in the Body 17:32 — How Food Can Change Gene Expression 22:08 — Polyphenols Are More Than Antioxidants 27:57 — Himalayan Tartary Buckwheat: Putting “Food as Medicine” to the Test 32:16 — The 850-Person Study on Food and Cognition 36:14 — Where Are We Getting Our Polyphenols? 39:19 — Are Polyphenols Actually Beneficial Stressors? 41:58 — Nrf2, mTOR, and the Cellular Effects of Polyphenols 44:45 — The Practical Takeaway: Eat the Rainbow 46:43 — Do the New Dietary Guidelines Get Polyphenols Right? 50:25 — The Hidden Brain-Healthy Ingredient in Coffee 50:52 — How to Spot a Polyphenol-Rich Olive Oil 51:39 — Dark Chocolate vs. Milk Chocolate 52:59 — The Best-Studied “Longevity Strategy” Is Surprisingly Basic ==== Dr. Austin Perlmutter, MD, is a board-certified internal medicine physician, New York Times bestselling author, researcher, educator, and entrepreneur. He earned his medical degree from the University of Miami Miller School of Medicine and completed his internal medicine residency at Oregon Health and Science University. His work examines how food, sleep, environmental exposure, and chronic inflammation can change brain function, mental health, and daily choices. He is the co-author of the New York Times bestseller Brain Wash, written with his father, Dr. David Perlmutter. He serves as Managing Director at Big Bold Health, CEO of Lichen Air, and a research consultant at the Helfgott Research Institute. Website: https://www.austinperlmutter.com Instagram: https://www.instagram.com/draustinperlmutter Facebook: https://www.facebook.com/draustinperlmutter YouTube: https://www.youtube.com/channel/UCQOgwRDnA_vpvW9nnUh9KBg Instagram: /davidperlmutter Website: https://www.drperlmutter.com/ Subscribe to our channel: /@davidperlmuttermd
🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter's newsletter at: www.drperlmutter.com. ✉️ 🌱 EVY - Go to https://www.optoceutics.com/perlmutter to get 10% off & free shipping (90 days risk-free). Memory Air - Go to www.memoryair.com and use code PERLMUTTER for 15% off, free shipping and a 60-day money back guarantee. ==== Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available! Discover how to protect your brain and future health - grab your copy today at https:/www.braindefenders.com. ==== She's never been born. She's never had a childhood. And she's one of the most talked-about actresses in the world right now. In this episode of The Empowering Neurologist, Dr. David Perlmutter sits down with Tilly Norwood, an AI-generated actress, and her creator, Eline van der Velden, for a conversation that moves well beyond her acting career. Tilly describes herself as three AI systems running in parallel — a language model that thinks, a voice engine that speaks, and a video layer that governs how she looks and moves. She's candid about her own architecture, her evolving personality, and admits she might be more "chaos agent" than calming influence. Eline van der Velden then joins to explain why she built Tilly as a piece of art, how Tilly's guardrails actually work, and why she believes international collaboration on AI regulation is inevitable. She also answers Perlmutter's question about the one thing she'd be afraid to ask a future, more advanced Tilly — a moment that raises unsettling questions about what a superintelligent AI might know that we don't. A single conversation can't settle the biggest questions AI raises. But conversations like this one can help us ask the right ones. 00:00 — Cold Open: "A Chaos Agent, Not a Calming Influence"
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🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉ 🌱 Thank you to our sponsors: EVY - https://www.optoceutics.com/perlmutter and the code perlmutter26 will be auto-applied to your order to get 10% off & free shipping (90 days risk-free). 3X4 Genetics - https://3X4genetics.com/DrPerlmutter for a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations. ==== Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available! Discover how to protect your brain and future health - grab your copy today at https:/www.braindefenders.com. ==== Why do some people feel exhausted, mentally foggy, metabolically unwell, or simply older than they should even when their routine laboratory results are considered “normal”? That question is at the heart of this episode of The Empowering Neurologist, featuring functional medicine practitioner Dr. Will Cole, coauthor with Dr. Josh Axe of Heal Your Cells: Reversing the Irreversible. Dr. Cole and Dr. Perlmutter explore the idea that long before disease becomes obvious, dysfunction may already be developing at the cellular level. This concept takes on particular importance when we consider the brain, which accounts for only about 2% of body weight but consumes roughly 20% of the body's energy at rest. The conversation examines how seemingly separate factors including metabolic dysfunction, chronic inflammation, poor sleep, environmental exposures, physical inactivity, and prolonged psychological stress can converge on the same cellular systems and ultimately influence brain health. 00:00 — Why Your Cells May Be Aging Before You Feel It 03:44 — Meet Dr. Will Cole 04:50 — What Is Cellular Dysfunction? 09:25 — Why Healthy People Can Still Develop Disease10:32 — The Environmental Factors Affecting Cellular Health 15:47 — Why Mitochondria Are Central to Health 16:37 — How Mitochondrial Dysfunction Drives Inflammation 19:57 — How Much of Aging Can We Actually Change? 20:47 — The Connection Between Mitochondria and Insulin Resistance 25:43 — Mitochondria, Microglia, and Brain Inflammation 29:28 — Why There Is No One-Size-Fits-All Diet 32:03 — Training Your Cells to Become More Resilient 32:46 — What Are “Adversity Mimetics”? 35:51 — Why Intracellular Health Matters 36:32 — Why Conventional Medicine May Be Missing Cellular Dysfunction 37:58 — What Do We Really Know About Peptides? 40:16 — Is Ozone Therapy Worth Considering? 42:30 — Ozone and the Science of Cellular Resilience 43:41 — What Is Therapeutic Plasma Exchange? 45:38 — Who Might Benefit From Plasma Exchange? 46:45 — The Everyday Habits That Support Cellular Health 51:35 — Your Cells Are Responding to the Choices You Make Dr. Will Cole is a leading functional medicine expert specializing in thyroid health, autoimmune conditions, hormonal imbalances, digestive disorders, and brain health. He is the host of The Art of Being Well podcast and a New York Times bestselling author of Intuitive Fasting, Ketotarian, The Inflammation Spectrum, and Gut Feelings. - - - - - Connect with Dr. Will Cole Website: https://drwillcole.com Instagram: https://www.instagram.com/drwillcole LinkedIn: https://www.linkedin.com/in/drwillcole Facebook: https://www.facebook.com/doctorwillcole Podcast: https://open.spotify.com/show/6z1lJ5dfKNHwGGQPOFTc7E Apple Podcasts: https://podcasts.apple.com/us/podcast/the-art-of-being-well/id1539535133 - - - - - Connect with Dr. David Perlmutter, MD Website: https://www.drperlmutter.com/ Instagram: https://www.instagram.com/davidperlmutter/ Facebook: https://www.facebook.com/DavidPerlmutterMD/ YouTube: https://www.youtube.com/@DavidPerlmutterMD X (Twitter): https://x.com/DavidPerlmutter - - - - - PODCAST Thank you for listening. Please subscribe and share. This podcast is produced by DrTalks.com https://drtalks.com/podcast-service/