The link between epigenetics and disease | Fab Mancini

You finally get the appointment. You tell your doctor you're not sleeping, the weight is climbing, and your moods feel like someone else's. You walk out with a prescription for an antidepressant, or with nothing at all. Dr. Deborah Kwolek, assistant professor of medicine at Harvard Medical School and director of Harvard's Women's Health and Menopause course, joins me to talk about why so many doctors were never taught menopause care and what she's doing to change it. We cover the exact questions to bring to your next appointment, your estrogen by the numbers, the labs to know, who may need to think harder about hormone therapy, and what to do when your doctor says, "I don't believe in hormones." Key Timestamps: 00:00 - Meet Dr. Deborah Kwolek

Your brain has its own immune cells, and the way you live each day helps decide whether they protect you or turn on you. Two-thirds of Americans living with Alzheimer's are women. Living longer doesn't explain that gap, girlfriend. So what does? I'm so happy to welcome back my dear friend Dr. David Perlmutter, board-certified neurologist and author of the New York Times bestseller Brain Defenders. He explains microglia, the immune cells that make up about 10% of your brain. On a good day, they're like firefighters in the firehouse, quietly repairing the blood-brain barrier and helping your brain build new connections. Under pressure from high blood sugar or inflammation, they can flip into what he calls the evil twin. Dr. Perlmutter walks me through what happens in the brain when estradiol drops in perimenopause and menopause, and how estrogen and your mitochondria, the energy makers inside your cells, keep each other going. He makes the case for caring about metabolic health in your 30s and 40s, long before memory changes show up. He shares the labs he wants on your radar, including hemoglobin A1C, homocysteine, fasting insulin, vitamin D and the p-tau217 blood test, plus why normal isn't the same as optimal. You'll hear why carrying the APOE4 gene is a predisposition, not a destiny, and exactly where he stands on hormone therapy for women. My favorite part was how oxytocin, my Queen Mother hormone, and time with the people you love help keep your brain's immune cells in their supportive state. You get to be the architect of your brain's destiny. This conversation shows you where to start. This episode is for educational purposes only and is not medical advice. Guest views are their own. Talk with your healthcare provider before making changes to your health routine or medications. Key Timestamps 00:00 Welcome back Dr. David Perlmutter and Brain Defenders

A divorce. A layoff. A season where you held everything together for everyone. Your body flipped into fight or flight to protect you, exactly the way it was built to. But what happens when the stress passes and your nervous system never gets the message? Bioenergetic medicine expert Dr. Sue Morter, author of The Energy Codes and The Anatomy of Awakening, explains the hidden stress your body can keep carrying for years. She shows how that old emergency ripples through your adrenals, your thyroid, and your hormones in midlife. Then she walks me through her first two steps. The wise belly breath, which helps engage the calming side of your nervous system. And pratyahara, an ancient practice for calling your energy back from the people and situations that drain you. Dr. Sue and I also get into what releasing anger means (hint, it's not dumping it on someone), how to work with a feeling without needing the whole story, and why meditation can feel impossible at first. If you've been doing everything right and still feel wired, tired, and on edge, Gorgeous, this one is for you. Key takeaways Your nervous system can stay locked in fight or flight long after a stressful event ends, because it never received the signal that the danger passed.

When a woman sits across from Dr. Anna after a breast cancer diagnosis, she asks one question. What did your oncologist say caused it? Almost every time, the answer is a blank stare. Dr. Nasha Winters has lived that silence from the inside. By 19, she had collected a decade of diagnoses, including PCOS, endometriosis, IBS, anxiety, and thyroid trouble. Then she landed in the ER with a grapefruit-sized tumor and was told she was too ill for treatment. In this conversation, she shares the three things she credits with changing her path. She also explains how childhood trauma can shape the immune system and why she sees the body as a garden to tend rather than a battlefield. Dr. Nasha is a naturopathic doctor and the author of The Metabolic Approach to Cancer. She walks through the ten areas of terrain she evaluates, the neutrophil-to-lymphocyte ratio hiding in a standard CBC, and her inflammation "trifecta" of CRP, sed rate, and LDH. She explains why ringing the bell after treatment is the beginning of rebuilding. She also shares the four S's she sees as common threads in breast health. Key takeaways Recurring symptoms and diagnoses can be signals worth investigating, not just labels to manage.

Tell me if you've heard this before. You're sleeping. You're eating the way you were told to eat. Your labs come back normal, and you still know something is off. That's the woman I had in mind for this conversation. After twenty years in hormone and longevity medicine, here's what I keep coming back to. Most of what supports your hormones comes down to the foundations, like light, darkness, and when you eat, and so many of them cost you nothing. My guest, Sarah Kleiner, is board-certified through the Quantum Biology Institute and the creator of My Circadian App. She came to this work the hard way. In her forties, she went through two pregnancy losses and two rounds of IVF with no viable embryos. Then a single conversation with Jack Kruse pointed her toward leptin and circadian biology. When she asked her fertility doctor to test her leptin, she was told it was an insignificant hormone. Her levels came back very low. She rebuilt her rhythm with morning sunlight, dark evenings, and a shift in how and when she ate, and she later got pregnant with her son without IVF. We get specific. Sarah explains what leptin does while you sleep and why she sees leptin resistance show up before insulin resistance. She covers the early hunger signals that something may be off and how to test leptin so the result means something. We talk through yellow versus orange and red blue light blockers, and why an incandescent bulb on your desk is worth it. We also cover why sitting in the shade still counts and why the same meal lands differently at 8 AM than at 8 PM. I also share why I built MenuPause around rotating eating patterns, especially if you've been doing carnivore, keto, or Keto-Green for a long time. Most of the women who find Sarah's work are in perimenopause and menopause. These small, consistent shifts give your body clearer instructions to work with. And the best years of your life are waiting for you.